Structural Biochemistry lab

Our research aims at the elucidation of protein structures and functions in order to further our understanding of the relationship between the two. Questions we want to answer are e.g. which specific structural features enable a particular function and how structural alterations affect it. We focus on medically or biotechnologically relevant proteins, with the main focus being on structural enzymology of pathways for uracil and thymine degradation. Major collaborative projects concern molecular recognition in immune complexes associated with development and progression of rheumatoid arthritis, and structural determinants that govern substrate specificity, regio- and stereoselectivity in laboratory-evolved enzyme variants of interest for biocatalysis applications. We use X-ray crystallography together with other biochemical and biophysical methods to explore structures, functions and interactions of these proteins.

PI: Doreen Dobritzsch-Lohkamp

Open positions

Postdoctoral research fellow in Structural Biochemistry

Duties

Structural and functional characterization of enzymes involved in uracil and thymine degradation and of proteins involved in pathway regulation

Entry requirements

A person is eligible for a position as postdoctoral research fellow if he or she obtained a PhD after 2010 at an academic institution other than Uppsala University.

We are seeking a motivated researcher to join an ongoing research project studying the function, structure, evolutionary adaptation and regulation of enzymes involved in two distinct pathways of pyrimidine degradation. The experiments will involve a broad range of techniques, such as protein expression/purification, site-directed mutagenesis, enzyme kinetics, interaction analysis, structure determination by X-ray crystallography and/or cryo-electron microscopy, and computational biochemistry.

The ideal candidate will hold a recently awarded Ph.D. in biochemistry, biological sciences or a related discipline. Applicants should have a background in biochemistry or protein chemistry, and possess experience with cloning and protein expression/purification techniques. Biochemists who would like to learn structural biology are encouraged to apply. Previous experience in bioinformatics, protein crystallography, cryo-EM, or mammalian cell culturing is a plus. Candidates that are highly motivated, creative, excellent team players, and with a good track record with at least two publication as first author are expected. This project is fully funded via a fellowship stipend for 2 years and also welcomes international exchange scholars to apply.

Application process

An employment application must contain the following documents in English:

  1. A personal letter with a short description of yourself and the reasons why you are interested in the position
  2. A complete curriculum vitae, including date of thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  3. A complete list of publications
  4. A summary of current work & previous experiences (no more than one page)
  5. Authorized copies of degrees and diplomas.
  6. Names and contact details of at least two scientists that have offered to act as references for you must also be included, with a clear indication of their relationship to you.
  7. Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline)

The application is to be submitted via email to Doreen.Dobritzsch at kemi.uu.se latest on December 15, 2018.

Division

The research program in biochemistry covers basic and applied research that spans a wide area, including enzymology, molecular cell biology, biophysics, structural biology, bioorganic synthesis and computer-based modeling. Many projects are run in collaboration with international research groups and in close cooperation with industry.

You can find more information about us here: http://www.kemi.uu.se/research/biochemistry/

Uppsala University is an international research university focused on the development of science and education. Our most important assets are the individuals, who with their curiosity and their dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 40,000 students, 7,000 employees and a turnover of SEK 6,5 billion. University strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.

The department of Chemistry – BMC is located within the Biomedical Center in Uppsala. We conduct teaching and outstanding research in areas of Analytical Chemistry, Biochemistry, Organic Chemistry and Physical Chemistry. Research education is given within all these subjects. We have interfaces towards pre-clinical biomedicine and the clinic, pharmacy, physics and materials science. The department has approximately 140 employees, and of them around 40 PhD students and 10 Professors.  

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Contact person: Doreen Dobritzsch-Lohkamp

Type of employment : Postdoctoral research fellow

Working hours Full time

Last application date 2018-12-15