Enzymology and Directed Protein Evolution
Enzyme catalysts are characterized by an unprecedented specificity for reactant molecules that will be acted upon. Often only a specific stereoisomer of a chiral molecule will be efficiently converted by a particular enzyme. Such specificity is of high value if applied to synthesis of chiral organic compounds where product purity is essential.
We study structure/function relationships in enzymes and use what we learn for the development of new and useful biocatalysts for specific and efficient catalysis of reactions generating chiral and pro-chiral product molecules.