Publikationer

  • van Kuilenburg, Andre B. P.; Tarailo-Graovac, Maja; Richmond, Phillip A.; Drogemoller, Britt I. et al.

    Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS

    Ingår i New England Journal of Medicine, s. 1433-1441, 2019.

  • Ge, Changrong; Xu, Bingze; Liang, Bibo; Lönnblom, Erik et al.

    Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies

    Ingår i Arthritis & Rheumatology, s. 210-221, 2019.

  • Maurer, Dirk; Lohkamp, Bernhard; Krumpel, Michael; Widersten, Mikael et al.

    Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism

    Ingår i Biochemical Journal, s. 2395-2416, 2018.

  • Hamnevik, Emil; Maurer, Dirk; Enugala, Thilak Reddy; Chu, Thao et al.

    Directed Evolution of Alcohol Dehydrogenase for Improved Stereoselective Redox Transformations of 1-Phenylethane-1,2-Diol and Its Corresponding Acyloin

    Ingår i Biochemistry, s. 1059-1062, 2018.

  • Janfalk Carlsson, Åsa; Bauer, Paul; Dobritzsch, Doreen; Kamerlin, Shina C Lynn et al.

    Epoxide Hydrolysis as a Model System for Understanding Flux Through a Branched Reaction Scheme

    Ingår i IUCrJ, s. 269-282, 2018.

    Open access
  • van Kuilenburg, André; Tarailo-Graovac, Maja; Meijer, Judith; Drogemoller, Britt et al.

    Genome sequencing reveals a novel genetic mechanism underlying dihydropyrimidine dehydrogenase deficiency: A novel missense variant c.1700G > A and a large intragenic inversion in DPYD spanning intron 8 to intron 12

    Ingår i Human Mutation, s. 947-953, 2018.

  • Hampel, Sabrina; Steitz, Jan-Patrick; Baierl, Anna; Lehwald, Patrizia et al.

    Structural and Mutagenesis Studies of the Thiamine-Dependent, Ketone-Accepting YerE from Pseudomonas protegens

    Ingår i ChemBioChem (Print), s. 2283-2292, 2018.

  • Ge, Changrong P; Tong, Dongmei R; Liang, Bibo T; Lönnblom, Erik S et al.

    Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage

    Ingår i JCI INSIGHT, 2017.

  • Nakajima, Yoko; Meijer, Judith; Dobritzsch, Doreen; Ito, Tetsuya et al.

    Dihydropyrimidinase deficiency in four East Asian patients due to novel and rare DPYS mutations affecting protein structural integrity and catalytic activity

    Ingår i Molecular Genetics and Metabolism, s. 216-222, 2017.

  • Porrmann, Joseph; Betcheva-Krajcir, Elitza; Di Donato, Nataliya; Kahlert, Anne-Karin et al.

    Novel PRPS1 gain-of-function mutation in a patient with congenital hyperuricemia and facial anomalies

    Ingår i American Journal of Medical Genetics. Part A, s. 2736-2742, 2017.

  • Hamnevik, Emil; Enugala, Thilak Reddy; Maurer, Dirk; Ntuku, Siphosethu et al.

    Relaxation of Nonproductive Binding and Increased Rate of Coenzyme Release in an Alcohol Dehydrogenase Increases Turnover With a Non-Preferred Alcohol Enantiomer

    Ingår i The FEBS Journal, s. 3895-3914, 2017.

    Open access
  • van Kuilenburg, André B P; Meijer, Judith; Maurer, Dirk; Dobritzsch, Doreen et al.

    Severe fluoropyrimidine toxicity due to novel and rare DPYD missense mutations, deletion and genomic amplification affecting DPD activity and mRNA splicing

    Ingår i Biochimica et Biophysica Acta, s. 721-730, 2017.

  • Nakajima, Yoko; Meijer, Judith; Zhang, Chunhua; Wang, Xu et al.

    Altered Pre-mRNA Splicing Caused by a Novel Intronic Mutation c.1443+5G>A in the Dihydropyrimidinase (DPYS) Gene.

    Ingår i International Journal of Molecular Sciences, 2016.

    Open access
  • Bauer, Paul; Janfalk Carlsson, Åsa; Amrein, Beat A.; Dobritzsch, Doreen et al.

    Conformational Diversity and Enantioconvergence in Potato Epoxide Hydrolase 1

    Ingår i Organic and biomolecular chemistry, s. 5639-5651, 2016.

    Open access
  • Doak, Bradley C; Zheng, Jie; Dobritzsch, Doreen; Kihlberg, Jan

    How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets.

    Ingår i Journal of Medicinal Chemistry, s. 2312-2327, 2016.

  • Janfalk Carlsson, Åsa; Bauer, Paul; Dobritzsch, Doreeen; Nilsson, Mikael et al.

    Laboratory evolved enzymes provide snapshots of the development of enantioconvergence in enzyme-catalyzed epoxide hydrolysis

    Ingår i ChemBioChem (Print), s. 1693-1697, 2016.

    Open access
  • Kuilenburg, André B P van; Meijer, Judith; Tanck, Michael W T; Dobritzsch, Doreen et al.

    Phenotypic and clinical implications of variants in the dihydropyrimidine dehydrogenase gene.

    Ingår i Biochimica et Biophysica Acta, s. 754-762, 2016.

  • Lindgren, Cecilia; Andersson, Ida E.; Berg, Lotta; Dobritzsch, Doreen et al.

    Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes

    Ingår i Organic and biomolecular chemistry, s. 6203-6216, 2015.

    Open access
  • Haag, Sabrina; Tuncel, Jonatan; Thordardottir, Soley; Mason, Daniel E. et al.

    Positional Identification of RT1-B (HLA-DQ) as Susceptibility Locus for Autoimmune Arthritis

    Ingår i Journal of Immunology, s. 2539-2550, 2015.

  • Nakajima, Yoko; Meijer, Judith; Dobritzsch, Doreen; Ito, Tetsuya et al.

    Clinical, biochemical and molecular analysis of 13 Japanese patients with beta-ureidopropionase deficiency demonstrates high prevalence of the c.977G > A (p.R326Q) mutation

    Ingår i Journal of Inherited Metabolic Disease, s. 801-812, 2014.

    Open access
  • Raposo, Bruno; Dobritzsch, Doreen; Ge, Changrong; Ekman, Diana et al.

    Epitope-specific antibody response is controlled by immunoglobuline VH polymorphisms

    Ingår i Journal of Experimental Medicine, s. 405-411, 2014.

  • Dobritzsch, Doreen; Wang, Huaming; Schneider, Gunter; Yu, Shukun

    Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme

    Ingår i Biochemical Journal, s. 441-452, 2014.

  • Claesson, Magnus; Siitonen, Vilja; Dobritzsch, Doreen; Metsä-Ketelä, Mikko et al.

    Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin in Streptomyces nogalater

    Ingår i The FEBS Journal, s. 3251-3263, 2012.

  • van Kuilenburg, André B P; Dobritzsch, Doreen; Meijer, Judith; Krumpel, Michael et al.

    ß-ureidopropionase deficiency: phenotype, genotype and protein structural consequences in 16 patients

    Ingår i Biochimica et Biophysica Acta, s. 1096-108, 2012.

    Open access
  • Dobritzsch, Doreen; Lindh, Ingrid; Uysal, Hüseyin; Nandakumar, Kutty S et al.

    Crystal structure of an arthritogenic anticollagen immune complex

    Ingår i Arthritis and Rheumatism, s. 3740-3748, 2011.

  • van Kuilenburg, André B P; Dobritzsch, Doreen; Meijer, Judith; Meinsma, Rutger et al.

    Dihydropyrimidinase deficiency: Phenotype, genotype and structural consequences in 17 patients

    Ingår i Biochimica et Biophysica Acta - Molecular Basis of Disease, s. 639-648, 2010.

  • Lohkamp, Bernhard; Voevodskaya, Nina; Lindqvist, Ylva; Dobritzsch, Doreen

    Insights into the mechanism of dihydropyrimidine dehydrogenase from site-directed mutagenesis targeting the active site loop and redox cofactor coordination

    Ingår i Biochimica et Biophysica Acta, s. 2198-2206, 2010.

  • van Kuilenburg, André B P; Meijer, Judith; Mul, Adri N P M; Meinsma, Rutger et al.

    Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity

    Ingår i Human Genetics, s. 529-538, 2010.

  • Lohkamp, Bernhard; Dobritzsch, Doreen

    A mixture of fortunes: the curious determination of the structure of Escherichia coli BL21 Gab protein

    Ingår i Acta Crystallographica Section D, s. 407-415, 2008.

  • Andersen, Birgit; Lundgren, Stina; Dobritzsch, Doreen; Piskur, Jure

    A recruited protease is involved in catabolism of pyrimidines

    Ingår i Journal of Molecular Biology, s. 243-250, 2008.

  • Schnackerz, Klaus D; Dobritzsch, Doreen

    Amidohydrolases of the reductive pyrimidine catabolic pathway: purification, characterization, structure, reaction mechanisms and enzyme deficiency

    Ingår i Biochimica et Biophysica Acta, s. 431-444, 2008.

  • Schnackerz, K D; Andersen, G; Dobritzsch, Doreen; Piskur, J

    Degradation of pyrimidines in Saccharomyces kluyveri: transamination of beta-alanine

    Ingår i Nucleosides, Nucleotides & Nucleic Acids, s. 794-799, 2008.

  • van Kuilenburg, A B P; Meijer, J; Dobritzsch, Doreen; Lohkamp, B et al.

    Identification of two novel mutations C79X and R235Q in the dihydropyrimidine dehydrogenase gene in a patient presenting with hematuria

    Ingår i Nucleosides, Nucleotides & Nucleic Acids, s. 809-815, 2008.

  • Beck, Halfdan; Dobritzsch, Doreen; Piskur, Jure

    Saccharomyces kluyveri as a model organism to study pyrimidine degradation

    Ingår i FEMS yeast research (Print), s. 1209-1213, 2008.

  • Lundgren, Stina; Lohkamp, Bernhard; Andersen, Birgit; Piskur, Jure et al.

    The crystal structure of beta-alanine synthase from Drosophila melanogaster reveals a homooctameric helical turn-like assembly

    Ingår i Journal of Molecular Biology, s. 1544-1559, 2008.

  • Andersen, Gorm; Andersen, Birgit; Dobritzsch, Doreen; Schnackerz, Klaus D et al.

    A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast

    Ingår i The FEBS Journal, s. 1804-1017, 2007.

  • van Kuilenburg, André B P; Meijer, Judith; Dobritzsch, Doreen; Meinsma, Rutger et al.

    Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency

    Ingår i Molecular Genetics and Metabolism, s. 157-164, 2007.

  • Koskiniemi, Hanna; Metsä-Ketelä, Mikko; Dobritzsch, Doreen; Kallio, Pauli et al.

    Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis

    Ingår i Journal of Molecular Biology, s. 633-648, 2007.

  • Lundgren, Stina; Andersen, Birgit; Piskur, Jure; Dobritzsch, Doreen

    Crystal structures of yeast beta-alanine synthase complexes reveal the mode of substrate binding and large scale domain closure movements

    Ingår i Journal of Biological Chemistry, s. 36037-36047, 2007.

  • Lundgren, Stina; Andersen, Birgit; Piskur, Jure; Dobritzsch, Doreen

    Crystallization and preliminary X-ray data analysis of beta-alanine synthase from Drosophila melanogaster

    Ingår i Acta Crystallographica. Section F, s. 874-877, 2007.

  • Andersen, G; Merico, A; Björnberg, O; Andersen, B et al.

    Catabolism of pyrimidines in yeast: a tool to understand degradation of anticancer drugs

    Ingår i Nucleosides, Nucleotides & Nucleic Acids, s. 991-996, 2006.

  • Lohkamp, Bernhard; Andersen, Birgit; Piskur, Jure; Dobritzsch, Doreen

    Purification, crystallization and X-ray diffraction analysis of dihydropyrimidinase from Dictyostelium discoideum

    Ingår i Acta Crystallographica. Section F, s. 36-38, 2006.

  • Lohkamp, Bernhard; Andersen, Birgit; Piskur, Jure; Dobritzsch, Doreen

    The crystal structures of dihydropyrimidinases reaffirm the close relationship between cyclic amidohydrolases and explain their substrate specificity

    Ingår i Journal of Biological Chemistry, s. 13762-13776, 2006.

  • Dobritzsch, Doreen; Andersen, Birgit; Piskur, Jure

    Crystallization and X-ray diffraction analysis of dihydropyrimidinase from Saccharomyces kluyveri

    Ingår i Acta Crystallographica. Section F, s. 359-362, 2005.

  • Van Kuilenburg, André B P; Meinsma, Rutger; Beke, Eva; Bobba, Barbara et al.

    Identification of three novel mutations in the dihydropyrimidine dehydrogenase gene associated with altered pre-mRNA splicing or protein function

    Ingår i Biological chemistry (Print), s. 319-324, 2005.

  • Schnackerz, Klaus D; Dobritzsch, Doreen; Lindqvist, Ylva; Cook, Paul F

    Dihydropyrimidine dehydrogenase: a flavoprotein with four iron-sulfur clusters

    Ingår i Biochimica et Biophysica Acta, s. 61-74, 2004.

  • Dobritzsch, Doreen; Gojković, Zoran; Andersen, Birgit; Piskur, Jure

    Crystallization and preliminary X-ray analysis of beta-alanine synthase from the yeast Saccharomyces kluyveri

    Ingår i Acta Crystallographica Section D, s. 1267-1269, 2003.

  • Lundgren, Stina; Gojković, Zoran; Piskur, Jure; Dobritzsch, Doreen

    Yeast beta-alanine synthase shares a structural scaffold and origin with dizinc-dependent exopeptidases

    Ingår i Journal of Biological Chemistry, s. 51851-51862, 2003.

  • Dobritzsch, Doreen; Ricagno, Stefano; Schneider, Gunter; Schnackerz, Klaus D et al.

    Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil: Implications for mechanism of inhibition and electron transfer

    Ingår i Journal of Biological Chemistry, s. 13155-13166, 2002.

  • van Kuilenburg, André B P; Dobritzsch, Doreen; Meinsma, Rutger; Haasjes, Janet et al.

    Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure

    Ingår i Biochemical Journal, s. 157-163, 2002.

  • Dobritzsch, Doreen; Schneider, G; Schnackerz, K D; Lindqvist, Y

    Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti-cancer drug 5-fluorouracil

    Ingår i EMBO Journal, s. 650-660, 2001.

  • Dobritzsch, Doreen; Persson, K; Schneider, G; Lindqvist, Y

    Crystallization and preliminary X-ray study of pig liver dihydropyrimidine dehydrogenase

    Ingår i Acta Crystallographica Section D, s. 153-155, 2001.

  • Lu, G; Dobritzsch, Doreen; Baumann, S; Schneider, G et al.

    The structural basis of substrate activation in yeast pyruvate decarboxylase: A crystallographic and kinetic study

    Ingår i European Journal of Biochemistry, s. 861-868, 2000.

  • Dobritzsch, Doreen; König, S; Schneider, G; Lu, G

    High resolution crystal structure of pyruvate decarboxylase from Zymomonas mobilis: Implications for substrate activation in pyruvate decarboxylases

    Ingår i Journal of Biological Chemistry, s. 20196-20204, 1998.

  • Lu, G; Dobritzsch, Doreen; König, S; Schneider, G

    Novel tetramer assembly of pyruvate decarboxylase from brewer's yeast observed in a new crystal form

    Ingår i FEBS Letters, s. 249-253, 1997.