Evolution has been using hydrogen gas as a food source, or fuel, in a hydrogen economy for millions of years, and certain microorganisms are capable of both producing and taking up hydrogen gas with extreme efficiency. This is accomplished by a family of enzymes called hydrogenases. We will prepare semi-synthetic, or artificial, hydrogenases by combining synthetic compounds with the natural enzyme inside living cells. This novel approach allows us to study these enzymes in great detail, with the aim of optimizing them for biotechnological applications while also developing new tools for working with metal containing proteins.
Gustav Berggren, Molekylär biomimetik.