Publications in Jan Kihlberg Group

Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice

Aoun, Mike; Coelho, Ana; Kraemer, Alexander; Saxena, Amit et al.

Part of Journal of Experimental Medicine, 2023.

DOI for Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice

Autoantibodies to Disease-Related Proteins in Joints as Novel Biomarkers for the Diagnosis of Rheumatoid Arthritis

Lönnblom, Erik; Leu Agelii, Monica; Sareila, Outi; Cheng, Lei et al.

Part of Arthritis & Rheumatology, p. 1110-1119, 2023.

DOI for Autoantibodies to Disease-Related Proteins in Joints as Novel Biomarkers for the Diagnosis of Rheumatoid Arthritis Download full text (pdf) of Autoantibodies to Disease-Related Proteins in Joints as Novel Biomarkers for the Diagnosis of Rheumatoid Arthritis

Macrocycles in Drug Discovery?Learning from the Past for the Future

Jiménez, Diego García; Poongavanam, Vasanthanathan; Kihlberg, Jan

Part of Journal of Medicinal Chemistry, p. 5377-5396, 2023.

DOI for Macrocycles in Drug Discovery?Learning from the Past for the Future Download full text (pdf) of Macrocycles in Drug Discovery?Learning from the Past for the Future

Therapy targeting antigen-specific T cells by a peptide-based tolerizing vaccine against autoimmune arthritis

Urbonaviciute, Vilma; Romero-Castillo, Laura; Xu, Bingze; Luo, Huqiao et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2023.

DOI for Therapy targeting antigen-specific T cells by a peptide-based tolerizing vaccine against autoimmune arthritis

Structure-based virtual screening discovers potent and selective adenosine A1 receptor antagonists

Matricon, Pierre; Nguyen, Anh T. N.; Vo, Duc Duy; Baltos, Jo-Anne et al.

Part of European Journal of Medicinal Chemistry, 2023.

DOI for Structure-based virtual screening discovers potent and selective adenosine A1 receptor antagonists Download full text (pdf) of Structure-based virtual screening discovers potent and selective adenosine A1 receptor antagonists

Predictive Modeling of PROTAC Cell Permeability with Machine Learning

Poongavanam, Vasanthanathan; Kölling, Florian; Giese, Anja; Göller, Andreas H. et al.

Part of ACS Omega, p. 5901-5916, 2023.

DOI for Predictive Modeling of PROTAC Cell Permeability with Machine Learning Download full text (pdf) of Predictive Modeling of PROTAC Cell Permeability with Machine Learning

Simulation Reveals the Chameleonic Behavior of Macrocycles

Sethio, Daniel; Poongavanam, Vasanthanathan; Xiong, Ruisheng; Tyagi, Mohit et al.

Part of Journal of Chemical Information and Modeling, p. 138-146, 2023.

DOI for Simulation Reveals the Chameleonic Behavior of Macrocycles Download full text (pdf) of Simulation Reveals the Chameleonic Behavior of Macrocycles

Going Viral: An Investigation into the Chameleonic Behaviour of Antiviral Compounds

Wieske, Lianne H. E.; Atilaw, Yoseph; Poongavanam, Vasanthanathan; Erdélyi, Máté et al.

Part of Chemistry - A European Journal, 2023.

DOI for Going Viral: An Investigation into the Chameleonic Behaviour of Antiviral Compounds Download full text (pdf) of Going Viral: An Investigation into the Chameleonic Behaviour of Antiviral Compounds

Conformational Sampling Deciphers the Chameleonic Properties of a VHL-Based Degrader

Ermondi, Giuseppe; Jimenez, Diego Garcia; Sebastiano, Matteo Rossi; Kihlberg, Jan et al.

Part of Pharmaceutics, 2023.

DOI for Conformational Sampling Deciphers the Chameleonic Properties of a VHL-Based Degrader Download full text (pdf) of Conformational Sampling Deciphers the Chameleonic Properties of a VHL-Based Degrader

Linker-Dependent Folding Rationalizes PROTAC Cell Permeability br

Poongavanam, Vasanthanathan; Atilaw, Yoseph; Siegel, Stephan; Giese, Anja et al.

Part of Journal of Medicinal Chemistry, p. 13029-13040, 2022.

DOI for Linker-Dependent Folding Rationalizes PROTAC Cell Permeability br Download full text (pdf) of Linker-Dependent Folding Rationalizes PROTAC Cell Permeability br

Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor

Ge, Changrong; Weisse, Sylvia; Xu, Bingze; Dobritzsch, Doreen et al.

Part of Annals of the Rheumatic Diseases, p. 480-489, 2022.

DOI for Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor Download full text (pdf) of Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor

Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction

Begnini, Fabio; Geschwindner, Stefan; Johansson, Patrik; Wissler, Lisa et al.

Part of Journal of Medicinal Chemistry, p. 3473-3517, 2022.

DOI for Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction Download full text (pdf) of Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction

Enhancing preclinical drug discovery with artificial intelligence

Vijayan, R. S. K.; Kihlberg, Jan; Cross, Jason B.; Poongavanam, Vasanthanathan

Part of Drug Discovery Today, p. 967-984, 2022.

DOI for Enhancing preclinical drug discovery with artificial intelligence Download full text (pdf) of Enhancing preclinical drug discovery with artificial intelligence

Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

Luttens, Andreas; Gullberg, Hjalmar; Abdurakhmanov, Eldar; Vo, Duy Duc et al.

Part of Journal of the American Chemical Society, p. 2905-2920, 2022.

DOI for Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses Download full text (pdf) of Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

PROTAC cell permeability and oral bioavailability: a journey into uncharted territory

Poongavanam, Vasanthanathan; Kihlberg, Jan

Part of Future Medicinal Chemistry, p. 123-126, 2022.

DOI for PROTAC cell permeability and oral bioavailability: a journey into uncharted territory

Structure-Guided Design of G-Protein-Coupled Receptor Polypharmacology

Kampen, Stefanie; Vo, Duc Duy; Zhang, Xiaoqun; Panel, Nicolas et al.

Part of Angewandte Chemie International Edition, p. 18022-18030, 2021.

DOI for Structure-Guided Design of G-Protein-Coupled Receptor Polypharmacology Download full text (pdf) of Structure-Guided Design of G-Protein-Coupled Receptor Polypharmacology

Cell Permeability of Isomeric Macrocycles: Predictions and NMR Studies

Begnini, Fabio; Poongavanam, Vasanthanathan; Atilaw, Yoseph; Erdélyi, Máté et al.

Part of ACS Medicinal Chemistry Letters, p. 983-990, 2021.

DOI for Cell Permeability of Isomeric Macrocycles: Predictions and NMR Studies Download full text (pdf) of Cell Permeability of Isomeric Macrocycles: Predictions and NMR Studies

Steering New Drug Discovery Campaigns: Permeability, Solubility, and Physicochemical Properties in the bRo5 Chemical Space

Caron, Giulia; Kihlberg, Jan; Goetz, Gilles; Ratkova, Ekaterina et al.

Part of ACS Medicinal Chemistry Letters, p. 13-23, 2021.

DOI for Steering New Drug Discovery Campaigns: Permeability, Solubility, and Physicochemical Properties in the bRo5 Chemical Space

Mining Natural Products for Macrocycles to Drug Difficult Targets

Begnini, Fabio; Poongavanam, Vasanthanathan; Over, Bjorn; Castaldo, Marie et al.

Part of Journal of Medicinal Chemistry, p. 1054-1072, 2021.

DOI for Mining Natural Products for Macrocycles to Drug Difficult Targets Download full text (pdf) of Mining Natural Products for Macrocycles to Drug Difficult Targets

Fragment-based design of selective GPCR ligands guided by free energy simulations

Matricon, Pierre; Vo, Duc Duy; Gao, Zhan-Guo; Kihlberg, Jan et al.

Part of Chemical Communications, p. 12305-12308, 2021.

DOI for Fragment-based design of selective GPCR ligands guided by free energy simulations Download full text (pdf) of Fragment-based design of selective GPCR ligands guided by free energy simulations

Solution Conformations Shed Light on PROTAC Cell Permeability

Atilaw, Yoseph; Poongavanam, Vasanthanathan; Svensson Nilsson, Caroline; Nguyen, Duy et al.

Part of ACS Medicinal Chemistry Letters, p. 107-114, 2021.

DOI for Solution Conformations Shed Light on PROTAC Cell Permeability Download full text (pdf) of Solution Conformations Shed Light on PROTAC Cell Permeability

Employing complementary spectroscopies to study the conformations of an epimeric pair of side-chain stapled peptides in aqueous solution

Bogaerts, Jonathan; Atilaw, Yoseph; Peintner, Stefan; Aerts, Roy et al.

Part of RSC Advances, p. 4200-4208, 2021.

DOI for Employing complementary spectroscopies to study the conformations of an epimeric pair of side-chain stapled peptides in aqueous solution Download full text (pdf) of Employing complementary spectroscopies to study the conformations of an epimeric pair of side-chain stapled peptides in aqueous solution

Predicting the permeability of macrocycles from conformational sampling – limitations of molecular flexibility

Poongavanam, Vasanthanathan; Atilaw, Yoseph; Ye, Sofie; Ermondi, Giuseppe et al.

Part of Journal of Pharmaceutical Sciences, p. 301-313, 2020.

DOI for Predicting the permeability of macrocycles from conformational sampling – limitations of molecular flexibility

Solubility prediction in the bRo5 chemical space: where are we right now?

Ermondi, Giuseppe; Poongavanam, Vasanthanathan; Vallaro, Maura; Kihlberg, Jan et al.

Part of ADMET and DMPK, p. 207-214, 2020.

DOI for Solubility prediction in the bRo5 chemical space: where are we right now? Download full text (pdf) of Solubility prediction in the bRo5 chemical space: where are we right now?

Solution Conformations Explain the Chameleonic Behaviour of Macrocyclic Drugs

Danelius, Emma; Poongavanam, Vasanthanathan; Peintner, Stefan; Wieske, Lianne H. E. et al.

Part of Chemistry - A European Journal, p. 5231-5244, 2020.

DOI for Solution Conformations Explain the Chameleonic Behaviour of Macrocyclic Drugs

Drug Syntheses Beyond the Rule of 5

Tyagi, Mohit; Begnini, Fabio; Poongavanam, Vasanthanathan; Doak, Bradley C. et al.

Part of Chemistry - A European Journal, p. 49-88, 2020.

DOI for Drug Syntheses Beyond the Rule of 5

Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1

Yang, Jie; Talibov, Vladimir O; Peintner, Stefan; Rhee, Claire et al.

Part of ACS Omega, p. 3979-3995, 2020.

DOI for Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1 Download full text (pdf) of Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1

Attempts to develop a cell-based assay for Diabetic Kidney Disease

Lindfors, Lina; Palm, Fredrik; Kihlberg, Jan

Is GPR146 really the receptor for proinsulin C-peptide?

Lindfors, Lina; Sundström, Linda; Fröderberg Roth, Linda; Meuller, Johan et al.

Part of Bioorganic & Medicinal Chemistry Letters, 2020.

DOI for Is GPR146 really the receptor for proinsulin C-peptide? Download full text (pdf) of Is GPR146 really the receptor for proinsulin C-peptide?

Tissue Specific Binding of Radiolabelled C-Peptide in Healthy and Diabetic Rats

Nensén, Oskar; Lindfors, Lina; Fasching, Angelica; Kihlberg, Jan et al.

Docking Finds GPCR Ligands in Dark Chemical Matter

Ballante, Flavio; Rudling, Axel; Zeifman, Alexey; Luttens, Andreas et al.

Part of Journal of Medicinal Chemistry, p. 613-620, 2020.

DOI for Docking Finds GPCR Ligands in Dark Chemical Matter

Conformation of the Macrocyclic Drug Lorlatinib in Polar and Nonpolar Environments: A MD Simulation and NMR Study

Peng, Cheng; Atilaw, Yoseph; Wang, Jinan; Xu, Zhijian et al.

Part of ACS Omega, p. 22245-22250, 2019.

DOI for Conformation of the Macrocyclic Drug Lorlatinib in Polar and Nonpolar Environments: A MD Simulation and NMR Study Download full text (pdf) of Conformation of the Macrocyclic Drug Lorlatinib in Polar and Nonpolar Environments: A MD Simulation and NMR Study

Intramolecular hydrogen bonding: An opportunity for improved design in medicinal chemistry

Caron, Giulia; Kihlberg, Jan; Ermondi, Giuseppe

Part of Medicinal research reviews (Print), p. 1707-1729, 2019.

DOI for Intramolecular hydrogen bonding: An opportunity for improved design in medicinal chemistry

Chemical and Biochemical Approaches for the Synthesis of Substituted Dihydroxybutanones and Di-, and Tri-Hydroxypentanones

Al-Smadi, Derar; Enugala, Thilak Reddy; Kessler, Vadim; Mhasal, Anil Rhanu et al.

Part of Journal of Organic Chemistry, p. 6982-6991, 2019.

DOI for Chemical and Biochemical Approaches for the Synthesis of Substituted Dihydroxybutanones and Di-, and Tri-Hydroxypentanones

Cyclophilin Succumbs to a Macrocyclic Chameleon

Doak, Bradley C.; Kihlberg, Jan

Part of Journal of Medicinal Chemistry, p. 9469-9472, 2018.

DOI for Cyclophilin Succumbs to a Macrocyclic Chameleon

Toward the Design of Molecular Chameleons: Flexible Shielding of an Amide Bond Enhances Macrocycle Cell Permeability

Tyagi, Mohit; Poongavanam, Vasanthanathan; Lindhagen, Marika; Pettersen, Anna et al.

Part of Organic Letters, p. 5737-5742, 2018.

DOI for Toward the Design of Molecular Chameleons: Flexible Shielding of an Amide Bond Enhances Macrocycle Cell Permeability

Conformational Sampling of Macrocyclic Drugs in Different Environments: Can We Find the Relevant Conformations?

Poongavanam, Vasanthanathan; Danelius, Emma; Peintner, Stefan; Alcaraz, Lilian et al.

Part of ACS Omega, p. 11742-11757, 2018.

DOI for Conformational Sampling of Macrocyclic Drugs in Different Environments: Can We Find the Relevant Conformations? Download full text (pdf) of Conformational Sampling of Macrocyclic Drugs in Different Environments: Can We Find the Relevant Conformations?

Dynamics Determine Signaling in a Multicomponent System Associated with Rheumatoid Arthritis

Lindgren, Cecilia; Tyagi, Mohit; Viljanen, Johan V.; Toms, Johannes et al.

Part of Journal of Medicinal Chemistry, p. 4774-4790, 2018.

DOI for Dynamics Determine Signaling in a Multicomponent System Associated with Rheumatoid Arthritis

Conformational Analysis of Rifampicin in Solution.

Wieske, Hermina; Danelius, Emma; Peintner, Stefan; Kihlberg, Jan et al.

2018.

Conformational Analysis of Rifampicin in Solution

Wieske, Hermina; Danelius, Emma; Peintner, Stefan; Kihlberg, Jan et al.

2018.

Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5

Sebastiano, Matteo Rossi; Doak, Bradley C.; Backlund, Maria; Poongavanam, Vasanthanathan et al.

Part of Journal of Medicinal Chemistry, p. 4189-4202, 2018.

DOI for Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5

Conformational Analysis of Rifampicin in Solution

Wieske, Hermina; Danelius, Emma; Peintner, Stefan; Kihlberg, Jan et al.

2018.

Download full text (pdf) of Conformational Analysis of Rifampicin in Solution

The Solvent Polarity Dependence of Macrocycles’ Conformations

Peintner, Stefan; Danelius, Emma; Poongavanam, Vasanthanathan; Erdelyi, Mate et al.

2018.

Download full text (pdf) of The Solvent Polarity Dependence of Macrocycles’ Conformations

Opportunities and guidelines for discovery of orally absorbed drugs in beyond rule of 5 space

Poongavanam, Vasanthanathan; Doak, Bradley Croy; Kihlberg, Jan

Part of Current Opinion in Chemical Biology, p. 23-29, 2018.

DOI for Opportunities and guidelines for discovery of orally absorbed drugs in beyond rule of 5 space

A Shared Epitope of Collagen Type XI and Type II Is Recognized by Pathogenic Antibodies in Mice and Human with Arthritis

Tong, Dongmei; Lönnblom, Erik; Yau, Anthony C. Y.; Nandakumar, Kutty Selva et al.

Part of Frontiers in Immunology, 2018.

DOI for A Shared Epitope of Collagen Type XI and Type II Is Recognized by Pathogenic Antibodies in Mice and Human with Arthritis Download full text (pdf) of A Shared Epitope of Collagen Type XI and Type II Is Recognized by Pathogenic Antibodies in Mice and Human with Arthritis

Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging

Bergman, Hilde-Marlene; Lindfors, Lina; Palm, Fredrik; Kihlberg, Jan et al.

Part of Analytical and Bioanalytical Chemistry, p. 2809-2816, 2019.

DOI for Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging Download full text (pdf) of Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging

Detection And Isolation Of Antigen Specific B Cells In Patients With Rheumatoid Arthritis

Nilsson, J.; Bergquist, M.; Onnheim, K.; Mårtensson, I-L et al.

Part of Annals of the Rheumatic Diseases, p. 779-779, 2017.

DOI for Detection And Isolation Of Antigen Specific B Cells In Patients With Rheumatoid Arthritis

T cells specific for post-translational modifications escape intrathymic tolerance induction

Raposo, Bruno; Merky, Patrick; Lundqvist, Christina; Yamada, Hisakata et al.

Part of Nature Communications, 2018.

DOI for T cells specific for post-translational modifications escape intrathymic tolerance induction Download full text (pdf) of T cells specific for post-translational modifications escape intrathymic tolerance induction

Cutting Edge: Processing of Oxidized Peptides in Macrophages Regulates T Cell Activation and Development of Autoimmune Arthritis

Yang, Min; Haase, Claus; Viljanen, Johan V.; Xu, Bingze et al.

Part of Journal of Immunology, p. 3937-3942, 2017.

DOI for Cutting Edge: Processing of Oxidized Peptides in Macrophages Regulates T Cell Activation and Development of Autoimmune Arthritis

Synthesis of substrates for aldolase-catalyzed reactions: A comparison of methods for the synthesis of substituted phenylacetaldehydes

Al-Smadi, Derar; Enugala, Thilak Reddy; Norberg, Thomas; Kihlberg, Jan et al.

Part of Synlett, p. 1187-1190, 2018.

DOI for Synthesis of substrates for aldolase-catalyzed reactions: A comparison of methods for the synthesis of substituted phenylacetaldehydes

Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms

Sareila, Outi; Hagert, Cecilia; Kelkka, Tiina; Linja, Marjo et al.

Part of Antioxidants and Redox Signaling, p. 1473-1490, 2017.

DOI for Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms

Integrative approaches in HIV-1 non-nucleoside reverse transcriptase inhibitor design

Poongavanam, Vasanthanathan; Vigneshwaran, Namashivayam; Vanagamudi, Murugesan; Hadi Al, Shamaileh et al.

Part of WIREs Comput Mol Sci, 2018.

DOI for Integrative approaches in HIV-1 non-nucleoside reverse transcriptase inhibitor design

Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage

Ge, Changrong P; Tong, Dongmei R; Liang, Bibo T; Lönnblom, Erik S et al.

Part of JCI INSIGHT, 2017.

DOI for Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage

How Big Is Too Big for Cell Permeability?

Matsson, Pär; Kihlberg, Jan

Part of Journal of Medicinal Chemistry, p. 1662-1664, 2017.

DOI for How Big Is Too Big for Cell Permeability?

Drug discovery beyond the rule of 5-Opportunities and challenges

Doak, Bradley C.; Kihlberg, Jan

Part of Expert Opinion on Drug Discovery, p. 115-119, 2017.

DOI for Drug discovery beyond the rule of 5-Opportunities and challenges

Structural and conformational determinants of macrocycle cell permeability

Over, Bjorn; Matsson, Pär; Tyrchan, Christian; Artursson, Per et al.

Part of Nature Chemical Biology, p. 1065-+, 2016.

DOI for Structural and conformational determinants of macrocycle cell permeability

Macrocyclic Prodrugs of a Selective Nonpeptidic Direct Thrombin Inhibitor Display High Permeability, Efficient Bioconversion but Low Bioavailability

Andersson, Vincent; Bergström, Fredrik; Branalt, Jonas; Grönberg, Gunnar et al.

Part of Journal of Medicinal Chemistry, p. 6658-6670, 2016.

DOI for Macrocyclic Prodrugs of a Selective Nonpeptidic Direct Thrombin Inhibitor Display High Permeability, Efficient Bioconversion but Low Bioavailability

Cell permeability beyond the rule of 5

Matsson, Pär; Doak, Bradley C.; Over, Björn; Kihlberg, Jan

Part of Advanced Drug Delivery Reviews, p. 42-61, 2016.

DOI for Cell permeability beyond the rule of 5

Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis

Andersson, Sofia E. M.; Eneljung, Tove; Tengvall, Sara; Jirholt, Pernilla et al.

Part of Arthritis Research & Therapy, 2016.

DOI for Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis Download full text (pdf) of Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis

Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis

Tengvall, Sara; Eneljung, Tove; Jirholt, Pernilla; Turesson, Olof et al.

Part of PLOS ONE, 2016.

DOI for Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis Download full text (pdf) of Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis

How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets.

Doak, Bradley C; Zheng, Jie; Dobritzsch, Doreen; Kihlberg, Jan

Part of Journal of Medicinal Chemistry, p. 2312-2327, 2016.

DOI for How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets.

Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes

Lindgren, Cecilia; Andersson, Ida E.; Berg, Lotta; Dobritzsch, Doreen et al.

Part of Organic and biomolecular chemistry, p. 6203-6216, 2015.

DOI for Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes Download full text (pdf) of Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes

Mild Oxidative Cleavage of 9-BBN-Protected Amino Acid Derivatives

Ankner, Tobias; Norberg, Thomas; Kihlberg, Jan

Part of European Journal of Organic Chemistry, p. 3767-3770, 2015.

DOI for Mild Oxidative Cleavage of 9-BBN-Protected Amino Acid Derivatives

Macrocyclic drugs and clinical candidates - what are the limits of oral bioavailability?

Doak, Bradley; Over, Bjorn; Giordanetto, Fabrizio; Kihlberg, Jan

Part of Abstracts of Papers of the American Chemical Society, 2014.

Macrocyclic drugs and clinical candidates: what can medicinal chemists learn from their properties?

Giordanetto, Fabrizio; Kihlberg, Jan

Part of Journal of Medicinal Chemistry, p. 278-95, 2014.

DOI for Macrocyclic drugs and clinical candidates: what can medicinal chemists learn from their properties?

Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates

Doak, Bradley Croy; Over, Bjorn; Giordanetto, Fabrizio; Kihlberg, Jan

Part of Chemistry and Biology, p. 1115-1142, 2014.

DOI for Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Over, Bjorn; McCarren, Patrick; Artursson, Per; Foley, Michael et al.

Part of Journal of Medicinal Chemistry, p. 2746-2754, 2014.

DOI for Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties