Our research projects
Divalent organochalcogen compounds possess unique antioxidative properties. They can act both as chain-breakers and as preventive, peroxide-decomposing antioxidants. Furthermore, in the presence of mild reducing agents they can perform in a catalytic fashion. We are presently involved in design, synthesis and evaluation of novel, “green”, chalcogen-based catalytic antioxidants which could be used in biological systems for antioxidant pharmacotherapy and for the stabilisation of natural and synthetic materials such as polymers, oils and fluids, paper and pulp products.
In addition to metal mediated synthesis, free radical chemistry has emerged as one of the most powerful tools in modern organic synthesis and homolytic carbon carbon bond-formation is today routinely considered in retrosynthetic analysis. We use readily available organoselenium and organotellurium compounds for radical cyclization and group transfer reactions.
Selenium is an essential trace element. Twentyfive selenoenzymes are present in man. However, their structure and function are often poorly understood. We design and synthesize novel organoselenium and organotellurium compounds which could be expected to mimic the actions of these selenoenzymes or have some other interesting biological activity. Evaluation is performed in collaboration with biochemists, medicinal chemists and pharmaceutical companies.