Epoxide hydrolase

The epoxide hydrolase StEH1 (from potato) has shown to be a highly suitable enzyme catalyst. The enzyme is stereospecific, easy to produce, structurally sturdy after mutagenesis and valuable structure/function data have been gathered. We are studying this enzyme, and in vitro evolved variants thereof, by a combination of structural, functional and computational methods.

Our research on StEH1 aims to...

  • establish structure/function relationships of enzyme-catalyzed epoxide ring opening reactions with special interest in stereoselectivity.
  • isolate new specific biocatalysts with desired functional and physicochemical properties.