Computational biochemistry - Lynn Kamerlin

The picture shows an enzyme in complex with a regulatory protein. The background features concentric circles representing the different levels of detail that are used for protein modeling.

The Kamerlin group develops and applies computational tools to solve important problems at the chemistry-biology interface. We use state-of-the-art computational techniques, including quantum mechanical, classical mechanical, and hybrids method to explore the physical and chemical aspects underlying enzyme catalysis. We are particularly interested in catalytic promiscuity and the evolution of protein function. Our aim is to develop new systems with greater catalytic proficiencies or altered functionalities. The lab takes an interdisciplinary approach, spanning physical organic chemistry, biochemistry, structural biology, and theory, and at each stage works closely with leading experimental collaborators.

Read more about our research on following page: ongoing research.

We also have an external website for our lab.