Publications within Biochemistry

Coherent diffractive imaging of proteins and viral capsids: simulating MS SPIDOC

Kierspel, Thomas; Kadek, Alan; Barran, Perdita; Bellina, Bruno et al.

Part of Analytical and Bioanalytical Chemistry, 2023.

DOI for Coherent diffractive imaging of proteins and viral capsids: simulating MS SPIDOC Download full text (pdf) of Coherent diffractive imaging of proteins and viral capsids: simulating MS SPIDOC

Comparison of purifying DARPins using conventional methods and self-cleaving affinity chromatography

Larsson, Sofia

2023.

Download full text (pdf) of Comparison of purifying DARPins using conventional methods and self-cleaving affinity chromatography

Conformational Selection of a Tryptophan Side Chain Drives the Generalized Increase in Activity of PET Hydrolases through a Ser/Ile Double Mutation

Crnjar, Alessandro; Grinen, Aransa; Kamerlin, Shina C. Lynn; Ramirez-Sarmiento, Cesar A.

Part of ACS ORGANIC & INORGANIC AU, p. 109-119, 2023.

DOI for Conformational Selection of a Tryptophan Side Chain Drives the Generalized Increase in Activity of PET Hydrolases through a Ser/Ile Double Mutation Download full text (pdf) of Conformational Selection of a Tryptophan Side Chain Drives the Generalized Increase in Activity of PET Hydrolases through a Ser/Ile Double Mutation

Benz, Caroline

Diving into short linear motifs: Large-scale identification of endogenous and host-pathogen protein-protein interactions and further characterized by deep mutational scanning

Room B42, BMC, Husargatan 3, Uppsala 2023-06-08 09:15

Download full text (pdf) of Benz, Caroline

Evaluation of affinity-purification coupled to mass spectrometry approaches for capture of short linear motif-based interactions

Kassa, Eszter; Jamshidi, Sara; Mihalič, Filip; Simonetti, Leandro et al.

Part of Analytical Biochemistry, 2023.

DOI for Evaluation of affinity-purification coupled to mass spectrometry approaches for capture of short linear motif-based interactions Download full text (pdf) of Evaluation of affinity-purification coupled to mass spectrometry approaches for capture of short linear motif-based interactions

Ground-state heterogeneity and vibrational energy redistribution in bacterial phytochrome observed with femtosecond 2D IR spectroscopy

Chenchiliyan, Manoop; Kuebel, Joachim; Ooi, Saik Ann; Salvadori, Giacomo et al.

Part of Journal of Chemical Physics, 2023.

DOI for Ground-state heterogeneity and vibrational energy redistribution in bacterial phytochrome observed with femtosecond 2D IR spectroscopy Download full text (pdf) of Ground-state heterogeneity and vibrational energy redistribution in bacterial phytochrome observed with femtosecond 2D IR spectroscopy

KIF-Key Interactions Finder: A program to identify the key molecular interactions that regulate protein conformational changes

Crean, Rory M.; Slusky, Joanna S. G.; Kasson, Peter M.; Kamerlin, Shina C. Lynn

Part of Journal of Chemical Physics, 2023.

DOI for KIF-Key Interactions Finder: A program to identify the key molecular interactions that regulate protein conformational changes Download full text (pdf) of KIF-Key Interactions Finder: A program to identify the key molecular interactions that regulate protein conformational changes

Q-RepEx: A Python pipeline to increase the sampling of empirical valence bond simulations

Brickel, Sebastian; Demkiv, Andrey O.; Crean, Rory M.; Pinto, Gaspar P. et al.

Part of Journal of Molecular Graphics and Modelling, 2023.

DOI for Q-RepEx: A Python pipeline to increase the sampling of empirical valence bond simulations Download full text (pdf) of Q-RepEx: A Python pipeline to increase the sampling of empirical valence bond simulations

Structures of lactaldehyde reductase, FucO, link enzyme activity to hydrogen bond networks and conformational dynamics

Zavarise, Alberto; Sridhar, Shruthi; Kiema, Tiila-Riikka; Wierenga, Rikkert K. et al.

Part of The FEBS Journal, p. 465-481, 2023.

DOI for Structures of lactaldehyde reductase, FucO, link enzyme activity to hydrogen bond networks and conformational dynamics Download full text (pdf) of Structures of lactaldehyde reductase, FucO, link enzyme activity to hydrogen bond networks and conformational dynamics

The Editorial

Zhang, Zhicheng; Zhang, Zhen; Sun, Zhenyu; Zhan, Shaoqi et al.

Part of Chemistry - An Asian Journal, 2023.

DOI for The Editorial

Brodmerkel, Maxim N.

Theoretical and Biochemical: Advancing Protein Structure Investigations with Complementing Computations

Room B41, Biomedicinska Centrum, Husargatan 3, Uppsala 2023-06-02 13:15

Download full text (pdf) of Brodmerkel, Maxim N.

5 suggestions to increase grant application success rates

Kamerlin, Shina C. Lynn

Part of EMBO Reports, 2022.

DOI for 5 suggestions to increase grant application success rates

A potent anesthetic drug salt: experimental and computational studies

Manjunatha, N. K.; Alzubaidy, Nabil Najib; Likhitha, U.; Manjunatha, M. et al.

Part of Journal of Molecular Structure, 2022.

DOI for A potent anesthetic drug salt: experimental and computational studies Download full text (pdf) of A potent anesthetic drug salt: experimental and computational studies

A Structural View into the Complexity of Carbon Dioxide Fixation

Kourist, Robert; Kamerlin, Shina C. Lynn

Part of ACS CENTRAL SCIENCE, p. 1040-1042, 2022.

DOI for A Structural View into the Complexity of Carbon Dioxide Fixation Download full text (pdf) of A Structural View into the Complexity of Carbon Dioxide Fixation

A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA Viruses

Lindqvist, Richard; Benz, Caroline; Sereikaite, Vita; Maassen, Lars et al.

Part of Viruses, 2022.

DOI for A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA Viruses Download full text (pdf) of A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA Viruses

Adventures on the Routes of Protein Evolution-In Memoriam Dan Salah Tawfik (1955-2021)

Jackson, Colin; Toth-Petroczy, Agnes; Kolodny, Rachel; Hollfelder, Florian et al.

Part of Journal of Molecular Biology, 2022.

DOI for Adventures on the Routes of Protein Evolution-In Memoriam Dan Salah Tawfik (1955-2021)

Antibodies to Cartilage Oligomeric Matrix Protein Are Pathogenic in Mice and May Be Clinically Relevant in Rheumatoid Arthritis

Ge, Changrong; Tong, Dongmei; Loennblom, Erik; Liang, Bibo et al.

Part of Arthritis & Rheumatology, p. 961-971, 2022.

DOI for Antibodies to Cartilage Oligomeric Matrix Protein Are Pathogenic in Mice and May Be Clinically Relevant in Rheumatoid Arthritis Download full text (pdf) of Antibodies to Cartilage Oligomeric Matrix Protein Are Pathogenic in Mice and May Be Clinically Relevant in Rheumatoid Arthritis

Barrel opening in the two-partner-secretion transporter FhaC studied via gas-phase molecular dynamics simulations

Wei, Chongyao

2022.

Download full text (pdf) of Barrel opening in the two-partner-secretion transporter FhaC studied via gas-phase molecular dynamics simulations

beta-Ureidopropionase deficiency due to novel and rare UPB1 mutations affecting pre-mRNA splicing and protein structural integrity and catalytic activity

Dobritzsch, Doreen; Meijer, Judith; Meinsma, Rutger; Maurer, Dirk et al.

Part of Molecular Genetics and Metabolism, p. 177-185, 2022.

DOI for beta-Ureidopropionase deficiency due to novel and rare UPB1 mutations affecting pre-mRNA splicing and protein structural integrity and catalytic activity Download full text (pdf) of beta-Ureidopropionase deficiency due to novel and rare UPB1 mutations affecting pre-mRNA splicing and protein structural integrity and catalytic activity

Complementing machine learning‐based structure predictions with native mass spectrometry

Allison, Timothy M.; Degiacomi, Matteo T.; Marklund, Erik; Jovine, Luca et al.

Part of Protein Science, 2022.

DOI for Complementing machine learning‐based structure predictions with native mass spectrometry Download full text (pdf) of Complementing machine learning‐based structure predictions with native mass spectrometry

Complex Loop Dynamics Underpin Activity, Specificity, and Evolvability in the (beta alpha)(8) Barrel Enzymes of Histidine and Tryptophan Biosynthesi

Romero-Rivera, Adrian; Corbella Morató, Marina; Parracino, Antonietta; Patrick, Wayne M. et al.

Part of JACS Au, p. 943-960, 2022.

DOI for Complex Loop Dynamics Underpin Activity, Specificity, and Evolvability in the (beta alpha)(8) Barrel Enzymes of Histidine and Tryptophan Biosynthesi Download full text (pdf) of Complex Loop Dynamics Underpin Activity, Specificity, and Evolvability in the (beta alpha)(8) Barrel Enzymes of Histidine and Tryptophan Biosynthesi

Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition

Li, Yitong; Balakrishnan, Vijaya Kumar; Rowse, Michael; Wu, Cheng-Guo et al.

Part of eLIFE, 2022.

DOI for Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition Download full text (pdf) of Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition

Development of biophysical assays for studies of PROTACs

Kovryzhenko, Daria

2022.

Download full text (pdf) of Development of biophysical assays for studies of PROTACs

Development of Monoclonal Antibodies to Detect for SARS-CoV-2 Proteins

Mishra, Nawneet; Teyra, Joan; Boytz, RuthMabel; Miersch, Shane et al.

Part of Journal of Molecular Biology, 2022.

DOI for Development of Monoclonal Antibodies to Detect for SARS-CoV-2 Proteins

Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3

Parenti, Marco Daniele; Naldi, Marina; Manoni, Elisabetta; Fabini, Edoardo et al.

Part of European Journal of Medicinal Chemistry, 2022.

DOI for Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3

Electrospray ionization of native membrane proteins proceeds via a charge equilibration step

Yen, Hsin-Yung; Abramsson, Mia L.; Agasid, Mark T.; Lama, Dilraj et al.

Part of RSC Advances, p. 9671-9680, 2022.

DOI for Electrospray ionization of native membrane proteins proceeds via a charge equilibration step Download full text (pdf) of Electrospray ionization of native membrane proteins proceeds via a charge equilibration step

Essential Functional Interplay of the Catalytic Groups in Acid Phosphatase

Pfeiffer, Martin; Crean, Rory M.; Moreira, Catia; Parracino, Antonietta et al.

Part of ACS Catalysis, p. 3357-3370, 2022.

DOI for Essential Functional Interplay of the Catalytic Groups in Acid Phosphatase Download full text (pdf) of Essential Functional Interplay of the Catalytic Groups in Acid Phosphatase

Exploiting enzyme evolution for computational protein design

Pinto, Gaspar P.; Corbella Morató, Marina; Demkiv, Andrey O.; Kamerlin, Shina C. Lynn

Part of TIBS -Trends in Biochemical Sciences. Regular ed., p. 375-389, 2022.

DOI for Exploiting enzyme evolution for computational protein design Download full text (pdf) of Exploiting enzyme evolution for computational protein design

Exploring interaction changes caused by disease-associated mutations in protein domains and short linear motifs

Lissmatz, Alice

2022.

Download full text (pdf) of Exploring interaction changes caused by disease-associated mutations in protein domains and short linear motifs

Facile Synthesis of 2-Hydroxyacetophenone from Racemic Styrene Oxide Catalyzed by Engineered Enzymes

Söderlund, Isac; Tjärnhage, Elias; Hamnevik, Emil; Widersten, Mikael

Part of Biotechnology letters, p. 985-990, 2022.

DOI for Facile Synthesis of 2-Hydroxyacetophenone from Racemic Styrene Oxide Catalyzed by Engineered Enzymes Download full text (pdf) of Facile Synthesis of 2-Hydroxyacetophenone from Racemic Styrene Oxide Catalyzed by Engineered Enzymes

Genome Evolution of a Symbiont Population for Pathogen Defense in Honeybees

Dyrhage, Karl; Garcia-Montaner, Andrea; Tamarit, Daniel; Seeger, Christian et al.

Part of Genome Biology and Evolution, 2022.

DOI for Genome Evolution of a Symbiont Population for Pathogen Defense in Honeybees Download full text (pdf) of Genome Evolution of a Symbiont Population for Pathogen Defense in Honeybees

High-Entropy Alloy Nanosheets for Fine-Tuning Hydrogen Evolution

Fu, Xianbiao; Zhang, Jiahao; Zhan, Shaoqi; Xia, Fanjie et al.

Part of ACS Catalysis, p. 11955-11959, 2022.

DOI for High-Entropy Alloy Nanosheets for Fine-Tuning Hydrogen Evolution

How viral proteins bind short linear motifs and intrinsically disordered domains

Madhu, Priyanka; Davey, Norman E.; Ivarsson, Ylva

Part of Essays in Biochemistry, p. 935-944, 2022.

DOI for How viral proteins bind short linear motifs and intrinsically disordered domains

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets

Mihalic, Filip; Benz, Caroline; Kassa, Eszter; Lindqvist, Richard et al.

Part of Nature Structural & Molecular Biology, 2022.

Influence of Cortisol on the Fibril Formation Kinetics of A beta 42 Peptide: A Multi-Technical Approach

Nucara, Alessandro; Ripanti, Francesca; Sennato, Simona; Nisini, Giacomo et al.

Part of International Journal of Molecular Sciences, 2022.

DOI for Influence of Cortisol on the Fibril Formation Kinetics of A beta 42 Peptide: A Multi-Technical Approach Download full text (pdf) of Influence of Cortisol on the Fibril Formation Kinetics of A beta 42 Peptide: A Multi-Technical Approach

Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases

Shen, Ruidan; Crean, Rory M.; Olsen, Keith J.; Corbella Morató, Marina et al.

Part of Chemical Science, p. 13524-13540, 2022.

DOI for Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases Download full text (pdf) of Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases

Is styrene competitive for dopamine receptor binding?

De Santis, Emiliano; Minicozzi, Velia; Rossi, Giancarlo; Stellato, Francesco et al.

Part of Biomolecular Concepts, p. 200-206, 2022.

DOI for Is styrene competitive for dopamine receptor binding? Download full text (pdf) of Is styrene competitive for dopamine receptor binding?

Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor

Ge, Changrong; Weisse, Sylvia; Xu, Bingze; Dobritzsch, Doreen et al.

Part of Annals of the Rheumatic Diseases, p. 480-489, 2022.

DOI for Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor Download full text (pdf) of Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor

Late-termination of pregnancy for medical reasons: when abortion isn't really by choice

Kamerlin, Shina C. Lynn

Part of EMBO Reports, 2022.

DOI for Late-termination of pregnancy for medical reasons: when abortion isn't really by choice

Mass Spectrometry and Machine Learning Reveal Determinants of Client Recognition by Antiamyloid Chaperones

Osterlund, Nicklas; Vosselman, Thibault; Leppert, Axel; Graslund, Astrid et al.

Part of Molecular & Cellular Proteomics, 2022.

DOI for Mass Spectrometry and Machine Learning Reveal Determinants of Client Recognition by Antiamyloid Chaperones Download full text (pdf) of Mass Spectrometry and Machine Learning Reveal Determinants of Client Recognition by Antiamyloid Chaperones

Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ

Al-Amin, Rasel A.; Johansson, Lars; Abdurakhmanov, Eldar; Landegren, Nils et al.

Part of Nucleic Acids Research, p. e129-e129, 2022.

DOI for Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ Download full text (pdf) of Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ

Monoclonal antibodies binding data for SARS-CoV-2 proteins

Mishra, Nawneet; Teyra, Joan; Boytz, RuthMabel; Miersch, Shane et al.

Part of Data in Brief, 2022.

DOI for Monoclonal antibodies binding data for SARS-CoV-2 proteins Download full text (pdf) of Monoclonal antibodies binding data for SARS-CoV-2 proteins

Optimisation of expression of trypsin in a bioreactor: A study based on Design of Experiment

Rane, Tova

2022.

Download full text (pdf) of Optimisation of expression of trypsin in a bioreactor: A study based on Design of Experiment

p Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs

Kliche, Johanna; Ivarsson, Ylva

Part of Biochemical Journal, p. 1-22, 2022.

DOI for p Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs Download full text (pdf) of p Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Bonagas, Nadilly; Gustafsson, Nina M. S.; Henriksson, Martin; Marttila, Petra et al.

Part of NATURE CANCER, p. 156-, 2022.

DOI for Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress Download full text (pdf) of Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Plasmonic zero mode waveguide for enhanced single molecule detection

Koya, Alemayehu Nana; Parracino, Antonietta

Part of NANOPHOTONICS IX, 2022.

DOI for Plasmonic zero mode waveguide for enhanced single molecule detection

ProP-PD for proteome-wide motif-mediated interaction discovery

Davey, Norman E.; Simonetti, Leandro; Ivarsson, Ylva

Part of TIBS -Trends in Biochemical Sciences. Regular ed., p. 547-548, 2022.

DOI for ProP-PD for proteome-wide motif-mediated interaction discovery Download full text (pdf) of ProP-PD for proteome-wide motif-mediated interaction discovery

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome

Benz, Caroline; Ali, Muhammad; Krystkowiak, Izabella; Simonetti, Leandro et al.

Part of Molecular Systems Biology, 2022.

DOI for Proteome-scale mapping of binding sites in the unstructured regions of the human proteome Download full text (pdf) of Proteome-scale mapping of binding sites in the unstructured regions of the human proteome

Sensitive protein detection using site-specifically oligonucleotide-conjugated nanobody reagents

Al-Amin, Rasel Abdullah; Muthelo, Phathutshedzo M.; Abdurakhmanov, Eldar; Vincke, Cecile et al.

Part of Analytical Chemistry, p. 10054-10061, 2022.

DOI for Sensitive protein detection using site-specifically oligonucleotide-conjugated nanobody reagents Download full text (pdf) of Sensitive protein detection using site-specifically oligonucleotide-conjugated nanobody reagents

Sequence specificity in DNA binding is mainly governed by association

Marklund, Emil; Mao, Guanzhong; Yuan, Jinwen; Zikrin, Spartak et al.

Part of Science, p. 442-445, 2022.

DOI for Sequence specificity in DNA binding is mainly governed by association Download full text (pdf) of Sequence specificity in DNA binding is mainly governed by association

Structure and Mechanism of a Cold-Adapted Bacterial Lipase

van der Ent, Florian; Lund, Bjarte A.; Svalberg, Linn; Purg, Miha et al.

Part of Biochemistry, p. 933-942, 2022.

DOI for Structure and Mechanism of a Cold-Adapted Bacterial Lipase Download full text (pdf) of Structure and Mechanism of a Cold-Adapted Bacterial Lipase

Substoichiometric Hsp104 regulates the genesis and persistence of self-replicable amyloid seeds of Sup35 prion domain

Mahapatra, Sayanta; Sarbahi, Anusha; Madhu, Priyanka; Swasthi, Hema M. et al.

Part of Journal of Biological Chemistry, 2022.

DOI for Substoichiometric Hsp104 regulates the genesis and persistence of self-replicable amyloid seeds of Sup35 prion domain Download full text (pdf) of Substoichiometric Hsp104 regulates the genesis and persistence of self-replicable amyloid seeds of Sup35 prion domain

Substrate targeting of kinases by short linear motifs

Rask, Emma

2022.

Download full text (pdf) of Substrate targeting of kinases by short linear motifs

The Binding Mechanism of Carbapenems in the Class A beta-lactamase IMI-1: A Molecular Dynamics Study of Ligand Stability

Lindahl, Isabell

2022.

Download full text (pdf) of The Binding Mechanism of Carbapenems in the Class A beta-lactamase IMI-1: A Molecular Dynamics Study of Ligand Stability

Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

Luttens, Andreas; Gullberg, Hjalmar; Abdurakhmanov, Eldar; Vo, Duy Duc et al.

Part of Journal of the American Chemical Society, p. 2905-2920, 2022.

DOI for Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses Download full text (pdf) of Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

Use of viral motif mimicry improves the proteome-wide discovery of human linear motifs

Wadie, Bishoy; Kleshchevnikov, Vitalii; Sandaltzopoulou, Elissavet; Benz, Caroline et al.

Part of Cell reports, 2022.

DOI for Use of viral motif mimicry improves the proteome-wide discovery of human linear motifs Download full text (pdf) of Use of viral motif mimicry improves the proteome-wide discovery of human linear motifs

A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma

Haugaard-Kedström, Linda M.; Clemmensen, Louise S.; Sereikaite, Vita; Jin, Zeyu et al.

Part of Journal of Medicinal Chemistry, p. 1423-1434, 2021.

DOI for A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma

Academic motherhood - what happens when you can't make it happen?

Kamerlin, Shina Caroline Lynn

Part of EMBO Reports, 2021.

DOI for Academic motherhood - what happens when you can't make it happen?

Costeira-Paulo, Joana

Advanced computations and mass-spectrometric techniques to unravel the dynamics and interactions of proteins

2021.

Download full text (pdf) of Costeira-Paulo, Joana

Charge Engineering Reveals the Roles of Ionizable Side Chains in Electrospray Ionization Mass Spectrometry

Abramsson, Mia L.; Sahin, Cagla; Hopper, Jonathan T. S.; Branca, Rui M. M. et al.

Part of JACS Au, p. 2385-2393, 2021.

DOI for Charge Engineering Reveals the Roles of Ionizable Side Chains in Electrospray Ionization Mass Spectrometry

Chemical Mapping Exposes the Importance of Active Site Interactions in Governing the Temperature Dependence of Enzyme Turnover

Winter, Samuel D.; Jones, Hannah B. L.; Rasadean, Dora M.; Crean, Rory M. et al.

Part of ACS Catalysis, p. 14854-14863, 2021.

DOI for Chemical Mapping Exposes the Importance of Active Site Interactions in Governing the Temperature Dependence of Enzyme Turnover Download full text (pdf) of Chemical Mapping Exposes the Importance of Active Site Interactions in Governing the Temperature Dependence of Enzyme Turnover

Co-therapy with S-adenosylmethionine and nicotinamide riboside improves t-cell survival and function in Arts Syndrome (PRPS1 deficiency)

Lenherr, Nina; Christodoulou, John; Duley, John; Dobritzsch, Doreen et al.

Part of Molecular Genetics and Metabolism Reports, 2021.

DOI for Co-therapy with S-adenosylmethionine and nicotinamide riboside improves t-cell survival and function in Arts Syndrome (PRPS1 deficiency) Download full text (pdf) of Co-therapy with S-adenosylmethionine and nicotinamide riboside improves t-cell survival and function in Arts Syndrome (PRPS1 deficiency)

Cytoplasmic short linear motifs in ACE2 and integrin beta(3) link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy

Kliche, Johanna; Kuss, Hanna; Ali, Muhammad; Ivarsson, Ylva

Part of Science Signaling, 2021.

DOI for Cytoplasmic short linear motifs in ACE2 and integrin beta(3) link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy

Development of biophysical methods for characterization of PROTACs

Oskar, Westlin

2021.

Download full text (pdf) of Development of biophysical methods for characterization of PROTACs

Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase

Talibov, Vladimir O; Fabini, Edoardo; FitzGerald, Edward; Tedesco, Daniele et al.

Part of ChemBioChem (Print), p. 1597-1608, 2021.

DOI for Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase Download full text (pdf) of Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase

Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

FitzGerald, Edward A.; Butko, Margaret T.; Boronat, Pierre; Cederfelt, Daniela et al.

Part of RSC Advances, p. 7527-7537, 2021.

DOI for Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor Download full text (pdf) of Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

Dissecting Inter-domain Cooperativity in the Folding of a Multi Domain Protein

Laursen, Louise; Gianni, Stefano; Jemth, Per

Part of Journal of Molecular Biology, 2021.

DOI for Dissecting Inter-domain Cooperativity in the Folding of a Multi Domain Protein

Distinct types of amyloid-beta oligomers displaying diverse neurotoxicity mechanisms in Alzheimer's disease

Madhu, Priyanka; Mukhopadhyay, Samrat

Part of Journal of Cellular Biochemistry, p. 1594-1608, 2021.

DOI for Distinct types of amyloid-beta oligomers displaying diverse neurotoxicity mechanisms in Alzheimer's disease

FitzGerald, Edward A.

Fragment-based drug discovery: Novel methods and strategies for identifying and evolving fragment leads

2021.

Download full text (pdf) of FitzGerald, Edward A.

Glycan-Induced Protein Dynamics in Human Norovirus P Dimers Depend on Virus Strain and Deamidation Status

Duelfer, Jasmin; Yan, Hao; Brodmerkel, Maxim N.; Creutznacher, Robert et al.

Part of Molecules, 2021.

DOI for Glycan-Induced Protein Dynamics in Human Norovirus P Dimers Depend on Virus Strain and Deamidation Status Download full text (pdf) of Glycan-Induced Protein Dynamics in Human Norovirus P Dimers Depend on Virus Strain and Deamidation Status

Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase

Gamiz-Arco, Gloria; Gutierrez-Rus, Luis I.; Risso, Valeria A.; Ibarra-Molero, Beatriz et al.

Part of Nature Communications, 2021.

DOI for Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase Download full text (pdf) of Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase

How to write a successful postdoc application: the PI perspective

Kamerlin, Shina Caroline Lynn

Part of EMBO Reports, 2021.

DOI for How to write a successful postdoc application: the PI perspective

Integrated analysis of Shank1 PDZ interactions with C-terminal and internal binding motifs

Ali, Muhammad; McAuley, Mishal Mariam; Lüchow, Susanne; Knapp, Stefan et al.

Part of Current Research in Structural Biology, p. 41-50, 2021.

DOI for Integrated analysis of Shank1 PDZ interactions with C-terminal and internal binding motifs Download full text (pdf) of Integrated analysis of Shank1 PDZ interactions with C-terminal and internal binding motifs

Investigation of styrene monooxygenase constructs in a biosynthesis pathway

Zeleskov, Dianna

2021.

Download full text (pdf) of Investigation of styrene monooxygenase constructs in a biosynthesis pathway

Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities

Kruse, Thomas; Benz, Caroline; Garvanska, Dimitriya H.; Lindqvist, Richard et al.

Part of Nature Communications, 2021.

DOI for Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities Download full text (pdf) of Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities

Loop Dynamics and Enzyme Catalysis in Protein Tyrosine Phosphatases

Crean, Rory M.; Biler, Michal; van der Kamp, Marc W.; Hengge, Alvan C. et al.

Part of Journal of the American Chemical Society, p. 3830-3845, 2021.

DOI for Loop Dynamics and Enzyme Catalysis in Protein Tyrosine Phosphatases Download full text (pdf) of Loop Dynamics and Enzyme Catalysis in Protein Tyrosine Phosphatases

Magneto-Optical Activity in Nonmagnetic Hyperbolic Nanoparticles

Kuttruff, Joel; Gabbani, Alessio; Petrucci, Gaia; Zhao, Yingqi et al.

Part of Physical Review Letters, 2021.

DOI for Magneto-Optical Activity in Nonmagnetic Hyperbolic Nanoparticles Download full text (pdf) of Magneto-Optical Activity in Nonmagnetic Hyperbolic Nanoparticles

Prenatal genetic screening and the evolving quest for "perfect babies": at what cost for genetic diversity?

Kamerlin, Shina Caroline Lynn

Part of EMBO Reports, 2021.

DOI for Prenatal genetic screening and the evolving quest for "perfect babies": at what cost for genetic diversity?

Protein orientation in time-dependent electric fields: orientation before destruction

Sinelnikova, Anna; Mandl, Thomas; Agelii, Harald; Grånäs, Oscar et al.

Part of Biophysical Journal, p. 3709-3717, 2021.

DOI for Protein orientation in time-dependent electric fields: orientation before destruction Download full text (pdf) of Protein orientation in time-dependent electric fields: orientation before destruction

Purification of His-tagged Proteins Using WorkBeads 40 TREN as a Pre-Treatment Step Prior Loading Sample onto IMAC Resins with the Purpose to Enhance Performance

Thorsén, Jenny

2021.

Download full text (pdf) of Purification of His-tagged Proteins Using WorkBeads 40 TREN as a Pre-Treatment Step Prior Loading Sample onto IMAC Resins with the Purpose to Enhance Performance

Recombinant antibody against Trypanosoma cruzi from patients with chronic Chagas heart disease recognizes mammalian nervous system

Niborski, Leticia L.; Potenza, Mariana; Chirivi, Renato G. S.; Simonetti, Leandro et al.

Part of EBioMedicine, 2021.

DOI for Recombinant antibody against Trypanosoma cruzi from patients with chronic Chagas heart disease recognizes mammalian nervous system Download full text (pdf) of Recombinant antibody against Trypanosoma cruzi from patients with chronic Chagas heart disease recognizes mammalian nervous system

Reproducibility in the unfolding process of protein induced by an external electric field

Sinelnikova, Anna; Mandl, Thomas; Östlin, Christofer; Grånäs, Oscar et al.

Part of Chemical Science, p. 2030-2038, 2021.

DOI for Reproducibility in the unfolding process of protein induced by an external electric field Download full text (pdf) of Reproducibility in the unfolding process of protein induced by an external electric field

Sexual conflict drives micro- and macroevolution of sexual dimorphism in immunity

Bagchi, Basabi; Corbel, Quentin; Khan, Imroze; Payne, Ellen et al.

Part of BMC Biology, 2021.

DOI for Sexual conflict drives micro- and macroevolution of sexual dimorphism in immunity Download full text (pdf) of Sexual conflict drives micro- and macroevolution of sexual dimorphism in immunity

Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases

Shen, Ruidan; Crean, Rory M.; Johnson, Sean J.; Kamerlin, Shina C. L. et al.

Part of JACS Au, p. 646-659, 2021.

DOI for Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases Download full text (pdf) of Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases

The N-terminal Helix-Turn-Helix Motif of Transcription Factors MarA and Rob Drives DNA Recognition

Corbella Morató, Marina; Liao, Qinghua; Moreira, Catia; Parracino, Antonietta et al.

Part of Journal of Physical Chemistry B, p. 6791-6806, 2021.

DOI for The N-terminal Helix-Turn-Helix Motif of Transcription Factors MarA and Rob Drives DNA Recognition Download full text (pdf) of The N-terminal Helix-Turn-Helix Motif of Transcription Factors MarA and Rob Drives DNA Recognition

Validation of anti-cytokeratin antibodies used in rapid cancer diagnostics by isoelectric focusing and QCM technology

Kostines, Reneh

2021.

Download full text (pdf) of Validation of anti-cytokeratin antibodies used in rapid cancer diagnostics by isoelectric focusing and QCM technology

A hydrophobic ratchet entrenches molecular complexes

Hochberg, Georg K. A.; Liu, Yang; Marklund, Erik; Metzger, Brian P. H. et al.

Part of Nature, p. 503-508, 2020.

DOI for A hydrophobic ratchet entrenches molecular complexes

An update on genetic variants of the NKX2-5

Kolomenski, Jorge E.; Delea, Marisol; Simonetti, Leandro; Fabbro, Monica C. et al.

Part of Human Mutation, p. 1187-1208, 2020.

DOI for An update on genetic variants of the NKX2-5

Atypical presentation of Arts syndrome due to a novel hemizygous loss-of-function variant in the PRPS1 gene

Puusepp, Sanna; Reinson, Karit; Pajusalu, Sander; van Kuilenburg, Andre B. P. et al.

Part of Molecular Genetics and Metabolism Reports, 2020.

DOI for Atypical presentation of Arts syndrome due to a novel hemizygous loss-of-function variant in the PRPS1 gene Download full text (pdf) of Atypical presentation of Arts syndrome due to a novel hemizygous loss-of-function variant in the PRPS1 gene

Biophysical Analysis of Novel Viral-Host Protein-Protein Interactions Identified by Proteomic Peptide Phage Display

Aronsson, Hanna

2020.

Download full text (pdf) of Biophysical Analysis of Novel Viral-Host Protein-Protein Interactions Identified by Proteomic Peptide Phage Display

Biophysical Characterization of Hit Compounds against a Structurally Dynamic Protein for Drug Discovery

Abramsson, Mia

2020.

Download full text (pdf) of Biophysical Characterization of Hit Compounds against a Structurally Dynamic Protein for Drug Discovery

Kulkarni, Yashraj

Computational Modeling of the Structure, Function and Dynamics of Biomolecular Systems

2020.

Download full text (pdf) of Kulkarni, Yashraj

Szeler, Klaudia

Computational Protein Evolution: Modeling the Selectivity and Promiscuity of Engineered Enzymes

2020.

Download full text (pdf) of Szeler, Klaudia

Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners

Zhu, Yanlei; Delhommel, Florent; Cordier, Florence; Lüchow, Susanne et al.

Part of Journal of Molecular Biology, p. 5920-5937, 2020.

DOI for Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners

Dissecting the Mechanism of (R)-3-Hydroxybutyrate Dehydrogenase by Kinetic Isotope Effects, Protein Crystallography, and Computational Chemistry

Machado, Teresa F. G.; Purg, Miha; McMahon, Stephen A.; Read, Benjamin J. et al.

Part of ACS Catalysis, p. 15019-15032, 2020.

DOI for Dissecting the Mechanism of (R)-3-Hydroxybutyrate Dehydrogenase by Kinetic Isotope Effects, Protein Crystallography, and Computational Chemistry Download full text (pdf) of Dissecting the Mechanism of (R)-3-Hydroxybutyrate Dehydrogenase by Kinetic Isotope Effects, Protein Crystallography, and Computational Chemistry

Engineering aldolases for asymmetric synthesis

Widersten, Mikael

Part of Methods in Enzymology, p. 149-167, 2020.

DOI for Engineering aldolases for asymmetric synthesis

Enhancing a de novo enzyme activity by computationally-focused ultra-low-throughput screening

Risso, Valeria A.; Romero-Rivera, Adrian; Gutierrez-Rus, Luis I.; Ortega-Muñoz, Mariano et al.

Part of Chemical Science, p. 6134-6148, 2020.

DOI for Enhancing a de novo enzyme activity by computationally-focused ultra-low-throughput screening Download full text (pdf) of Enhancing a de novo enzyme activity by computationally-focused ultra-low-throughput screening

Enzyme Evolution An Epistatic Ratchet versus a Smooth Reversible Transition

Ben-David, Moshe; Soskine, Misha; Dubovetskyi, Artem; Cherukuri, Kesava-Phaneendra et al.

Part of Molecular biology and evolution, p. 1133-1147, 2020.

DOI for Enzyme Evolution An Epistatic Ratchet versus a Smooth Reversible Transition

Errors in DFT integration grids and their potential impact on chemical shift calculations

Wilson, Philippe B.; Grootveld, Martin; Kamerlin, Shina C. Lynn

Part of Magnetic Resonance in Chemistry, p. 116-117, 2020.

DOI for Errors in DFT integration grids and their potential impact on chemical shift calculations

Establishing Trypanosoma cruzi farnesyl pyrophosphatesynthase as a viable target for biosensor driven fragment-based lead discovery

Opassi, Giulia; Nordström, Helena; Lundin, Arne; Napolitano, Valeria et al.

Part of Protein Science, p. 991-1003, 2020.

DOI for Establishing Trypanosoma cruzi farnesyl pyrophosphatesynthase as a viable target for biosensor driven fragment-based lead discovery Download full text (pdf) of Establishing Trypanosoma cruzi farnesyl pyrophosphatesynthase as a viable target for biosensor driven fragment-based lead discovery

Estimating Detection Limits of Potentiometric DNA sensors Using Surface Plasmon Resonance Analyses

Xu, Xingxing; Makaraviciute, Asta; Abdurakhmanov, Eldar; Werneling, Fredrik et al.

Part of ACS Sensors, p. 217-224, 2020.

DOI for Estimating Detection Limits of Potentiometric DNA sensors Using Surface Plasmon Resonance Analyses

Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment

Öhman Fuchs, Peder; Calitz, Carlemi; Pavlovic, Natasa; Binet, Francois et al.

Part of Cellular Signalling, 2020.

DOI for Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment Download full text (pdf) of Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment

Free energy calculation using space filled design and weighted reconstruction: a modified single sweep approach

Bhaduri, Anindya; Gardner, Jasmine; Abrams, Cameron F.; Graham-Brady, Lori

Part of Molecular Simulation, p. 193-206, 2020.

DOI for Free energy calculation using space filled design and weighted reconstruction: a modified single sweep approach

Genetically Encoded Cyclic Peptide Phage Display Libraries

Simonetti, Leandro; Ivarsson, Ylva

Part of ACS CENTRAL SCIENCE, p. 336-338, 2020.

DOI for Genetically Encoded Cyclic Peptide Phage Display Libraries Download full text (pdf) of Genetically Encoded Cyclic Peptide Phage Display Libraries

G-Protein coupled receptors: structure and function in drug discovery

Odoemelam, Chiemela S.; Percival, Benita; Wallis, Helen; Chang, Ming-Wei et al.

Part of RSC Advances, p. 36337-36348, 2020.

DOI for G-Protein coupled receptors: structure and function in drug discovery Download full text (pdf) of G-Protein coupled receptors: structure and function in drug discovery

Ground-State Destabilization by Active-Site Hydrophobicity Controls the Selectivity of a Cofactor-Free Decarboxylase

Biler, Michal; Crean, Rory M.; Schweiger, Anna K.; Kourist, Robert et al.

Part of Journal of the American Chemical Society, p. 20216-20231, 2020.

DOI for Ground-State Destabilization by Active-Site Hydrophobicity Controls the Selectivity of a Cofactor-Free Decarboxylase Download full text (pdf) of Ground-State Destabilization by Active-Site Hydrophobicity Controls the Selectivity of a Cofactor-Free Decarboxylase

Harnessing Conformational Plasticity to Generate Designer Enzymes

Crean, Rory M.; Gardner, Jasmine M.; Kamerlin, Shina C. Lynn

Part of Journal of the American Chemical Society, p. 11324-11342, 2020.

DOI for Harnessing Conformational Plasticity to Generate Designer Enzymes Download full text (pdf) of Harnessing Conformational Plasticity to Generate Designer Enzymes

Ali, Muhammad

Identification of SLiMs: Mapping and characterizing motif-based protein interactions

2020.

Download full text (pdf) of Ali, Muhammad

Inhibition properties of free and conjugated leupeptin analogues

Billinger, Erika; Viljanen, Johan V.; Lind Bergström, Sara; Johansson, Gunnar

2020.

DOI for Inhibition properties of free and conjugated leupeptin analogues Download full text (pdf) of Inhibition properties of free and conjugated leupeptin analogues

Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1

Yang, Jie; Talibov, Vladimir O; Peintner, Stefan; Rhee, Claire et al.

Part of ACS Omega, p. 3979-3995, 2020.

DOI for Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1 Download full text (pdf) of Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1

Managing Coronavirus Disease 2019 Spread With Voluntary Public Health Measures: Sweden as a Case Study for Pandemic Control

Kamerlin, Shina C. L.; Kasson, Peter M.

Part of Clinical Infectious Diseases, p. 3174-3181, 2020.

DOI for Managing Coronavirus Disease 2019 Spread With Voluntary Public Health Measures: Sweden as a Case Study for Pandemic Control Download full text (pdf) of Managing Coronavirus Disease 2019 Spread With Voluntary Public Health Measures: Sweden as a Case Study for Pandemic Control

Manipulating Conformational Dynamics To Repurpose Ancient Proteins for Modern Catalytic Functions

Gardner, Jasmine M.; Biler, Michal; Risso, Valeria A.; Sanchez-Ruiz, Jose M. et al.

Part of ACS Catalysis, p. 4863-4870, 2020.

DOI for Manipulating Conformational Dynamics To Repurpose Ancient Proteins for Modern Catalytic Functions Download full text (pdf) of Manipulating Conformational Dynamics To Repurpose Ancient Proteins for Modern Catalytic Functions

Modeling the Alkaline Hydrolysis of Diaryl Sulfate Diesters: A Mechanistic Study

Szeler, Klaudia; Williams, Nicholas H.; Hengge, Alvan C.; Kamerlin, Shina C. Lynn

Part of Journal of Organic Chemistry, p. 6489-6497, 2020.

DOI for Modeling the Alkaline Hydrolysis of Diaryl Sulfate Diesters: A Mechanistic Study Download full text (pdf) of Modeling the Alkaline Hydrolysis of Diaryl Sulfate Diesters: A Mechanistic Study

Modeling the Role of a Flexible Loop and Active Site Side Chains in Hydride Transfer Catalyzed by Glycerol-3-phosphate Dehydrogenase

Mhasal, Anil Rhanu; Romero-Rivera, Adrian; Mydy, Lisa S.; Cristobal, Judith R. et al.

Part of ACS Catalysis, p. 11253-11267, 2020.

DOI for Modeling the Role of a Flexible Loop and Active Site Side Chains in Hydride Transfer Catalyzed by Glycerol-3-phosphate Dehydrogenase Download full text (pdf) of Modeling the Role of a Flexible Loop and Active Site Side Chains in Hydride Transfer Catalyzed by Glycerol-3-phosphate Dehydrogenase

Lüking, Malin

Modelling the Protein-DNA Interface

2020.

Open Access, Plan S, and researchers' needs

Kamerlin, Shina Caroline Lynn

Part of EMBO Reports, 2020.

DOI for Open Access, Plan S, and researchers' needs Download full text (pdf) of Open Access, Plan S, and researchers' needs

Predicting the Shapes of Protein Complexes through Collision Cross Section Measurements and Database Searches

Landreh, Michael; Sahin, Cagla; Gault, Joseph; Sadeghi, Samira et al.

Part of Analytical Chemistry, p. 12297-12303, 2020.

DOI for Predicting the Shapes of Protein Complexes through Collision Cross Section Measurements and Database Searches

Profiling calcium-dependent interactions between Sorcin and intrinsically disordered regions of human proteome

Genovese, Ilaria; Carotti, Andrea; Ilari, Andrea; Fiorillo, Annarita et al.

Part of Biochimica et Biophysica Acta - General Subjects, 2020.

DOI for Profiling calcium-dependent interactions between Sorcin and intrinsically disordered regions of human proteome

Recent Advances in Understanding Biological GTP Hydrolysis through Molecular Simulation

Calixto, Ana Rita; Moreira, Catia; Kamerlin, Shina Caroline Lynn

Part of ACS Omega, p. 4380-4385, 2020.

DOI for Recent Advances in Understanding Biological GTP Hydrolysis through Molecular Simulation Download full text (pdf) of Recent Advances in Understanding Biological GTP Hydrolysis through Molecular Simulation

Structural Heterogeneity in Single Particle Imaging Using X-ray Lasers

Mandl, Thomas; Östlin, Christofer; Dawod, Ibrahim E.; Brodmerkel, Maxim N. et al.

Part of Journal of Physical Chemistry Letters, p. 6077-6083, 2020.

DOI for Structural Heterogeneity in Single Particle Imaging Using X-ray Lasers Download full text (pdf) of Structural Heterogeneity in Single Particle Imaging Using X-ray Lasers

Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling

Wigington, Callie P.; Roy, Jagoree; Damle, Nikhil P.; Yadav, Vikash K. et al.

Part of Molecular Cell, p. 342-+, 2020.

DOI for Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling

The Role of Substrate-Coenzyme Crosstalk in Determining Turnover Rates in Rhodococcus ruber Alcohol Dehydrogenase

Enugala, Thilak Reddy; Corbella Morató, Marina; Kamerlin, Shina C. L.; Widersten, Mikael

Part of ACS Catalysis, p. 9115-9128, 2020.

DOI for The Role of Substrate-Coenzyme Crosstalk in Determining Turnover Rates in Rhodococcus ruber Alcohol Dehydrogenase Download full text (pdf) of The Role of Substrate-Coenzyme Crosstalk in Determining Turnover Rates in Rhodococcus ruber Alcohol Dehydrogenase

When we increase diversity in academia, we all win

Kamerlin, Shina C. Lynn

Part of EMBO Reports, 2020.

DOI for When we increase diversity in academia, we all win

A Consensus Binding Motif for the PP4 Protein Phosphatase

Ueki, Yumi; Kruse, Thomas; Weisser, Melanie Bianca; Sundell, Gustav N. et al.

Part of Molecular Cell, p. 953-964.e6, 2019.

DOI for A Consensus Binding Motif for the PP4 Protein Phosphatase

A strategy for the identification of protein architectures directly from ion mobility mass spectrometry data reveals stabilizing subunit interactions in light harvesting complexes

Kaldmae, Margit; Sahin, Cagla; Saluri, Mihkel; Marklund, Erik et al.

Part of Protein Science, p. 1024-1030, 2019.

DOI for A strategy for the identification of protein architectures directly from ion mobility mass spectrometry data reveals stabilizing subunit interactions in light harvesting complexes Download full text (pdf) of A strategy for the identification of protein architectures directly from ion mobility mass spectrometry data reveals stabilizing subunit interactions in light harvesting complexes

Affinity and specificity of motif-based protein-protein interactions

Ivarsson, Ylva; Jemth, Per

Part of Current opinion in structural biology, p. 26-33, 2019.

DOI for Affinity and specificity of motif-based protein-protein interactions Download full text (pdf) of Affinity and specificity of motif-based protein-protein interactions

Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases

Burke, Jason R.; La Clair, James J.; Philippe, Ryan N.; Pabis, Anna et al.

Part of ACS Catalysis, p. 8388-8396, 2019.

DOI for Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases

Characterization of Serine Protease Inhibitor from Solanum tuberosum Conjugated to Soluble Dextran and Particle Carriers

Billinger, Erika; Zuo, Shusheng; Johansson, Gunnar

Part of ACS Omega, p. 18456-18464, 2019.

DOI for Characterization of Serine Protease Inhibitor from Solanum tuberosum Conjugated to Soluble Dextran and Particle Carriers Download full text (pdf) of Characterization of Serine Protease Inhibitor from Solanum tuberosum Conjugated to Soluble Dextran and Particle Carriers

Chemical and Biochemical Approaches for the Synthesis of Substituted Dihydroxybutanones and Di-, and Tri-Hydroxypentanones

Al-Smadi, Derar; Enugala, Thilak Reddy; Kessler, Vadim; Mhasal, Anil Rhanu et al.

Part of Journal of Organic Chemistry, p. 6982-6991, 2019.

DOI for Chemical and Biochemical Approaches for the Synthesis of Substituted Dihydroxybutanones and Di-, and Tri-Hydroxypentanones

Chromatographic Data Segmentation Method: A Hybrid Analytical Approach for the Investigation of Antiviral Substances in Medicinal Plant Extracts

Drevinskas, Tomas; Maruska, Audrius; Telksnys, Laimutis; Hjertén, Stellan et al.

Part of Analytical Chemistry, p. 1080-1088, 2019.

DOI for Chromatographic Data Segmentation Method: A Hybrid Analytical Approach for the Investigation of Antiviral Substances in Medicinal Plant Extracts

Computational physical organic chemistry using the empirical valence bond approach

Kulkarni, Yashraj; Kamerlin, Shina C. Lynn

Part of Advances in Physical Organic Chemistry, p. 69-104, 2019.

DOI for Computational physical organic chemistry using the empirical valence bond approach Download full text (pdf) of Computational physical organic chemistry using the empirical valence bond approach

Conformational diversity induces nanosecond-timescale chemical disorder in the HIV-1 protease reaction pathway

Calixto, Ana Rita; Ramos, Maria Joao; Fernandes, Pedro Alexandrino

Part of Chemical Science, p. 7212-7221, 2019.

DOI for Conformational diversity induces nanosecond-timescale chemical disorder in the HIV-1 protease reaction pathway

Editorial overview: Folding and binding

Ivarsson, Ylva; Jemth, Per

Part of Current opinion in structural biology, p. 139-140, 2019.

DOI for Editorial overview: Folding and binding

Energetics of Flap Opening in HIV-1 Protease: String Method Calculations

Gardner, Jasmine M.; Abrams, Cameron F.

Part of Journal of Physical Chemistry B, p. 9584-9591, 2019.

DOI for Energetics of Flap Opening in HIV-1 Protease: String Method Calculations

Gas-Phase Collisions with Trimethylamine-N-Oxide Enable Activation-Controlled Protein Ion Charge Reduction

Kaldmäe, Margit; Österlund, Nicklas; Lianoudaki, Danai; Sahin, Cagla et al.

Part of Journal of the American Society for Mass Spectrometry, p. 1385-1388, 2019.

DOI for Gas-Phase Collisions with Trimethylamine-N-Oxide Enable Activation-Controlled Protein Ion Charge Reduction Download full text (pdf) of Gas-Phase Collisions with Trimethylamine-N-Oxide Enable Activation-Controlled Protein Ion Charge Reduction

Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS

van Kuilenburg, Andre B. P.; Tarailo-Graovac, Maja; Richmond, Phillip A.; Drogemoller, Britt I. et al.

Part of New England Journal of Medicine, p. 1433-1441, 2019.

DOI for Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS

GTP Hydrolysis Without an Active Site Base: A Unifying Mechanism for Ras and Related GTPases

Calixto, Ana R.; Moreira, Catia; Pabis, Anna; Kötting, Carsten et al.

Part of Journal of the American Chemical Society, p. 10684-10701, 2019.

DOI for GTP Hydrolysis Without an Active Site Base: A Unifying Mechanism for Ras and Related GTPases

Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme

Yang, Gloria; Anderson, Dave W.; Baier, Florian; Dohmen, Elias et al.

Part of Nature Chemical Biology, p. 1120-1128, 2019.

DOI for Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme

Light scattering determination of the stoichiometry for protease-potato serine protease inhibitor complexes

Billinger, Erika; Zuo, Shusheng; Lundmark, Kristoffer; Johansson, Gunnar

Part of Analytical Biochemistry, 2019.

DOI for Light scattering determination of the stoichiometry for protease-potato serine protease inhibitor complexes

Long Time-Scale Atomistic Simulations of the Structure and Dynamics of Transcription Factor-DNA Recognition

Liao, Qinghua; Lüking, Malin; Krueger, Dennis M.; Deindl, Sebastian et al.

Part of Journal of Physical Chemistry B, p. 3576-3590, 2019.

DOI for Long Time-Scale Atomistic Simulations of the Structure and Dynamics of Transcription Factor-DNA Recognition Download full text (pdf) of Long Time-Scale Atomistic Simulations of the Structure and Dynamics of Transcription Factor-DNA Recognition

Negative piezoelectric effect in an organic supramolecular ferroelectric

Urbanaviciute, Indre; Meng, Xiao; Biler, Michal; Wei, Yingfen et al.

Part of Materials Horizons, p. 1688-1698, 2019.

DOI for Negative piezoelectric effect in an organic supramolecular ferroelectric Download full text (pdf) of Negative piezoelectric effect in an organic supramolecular ferroelectric

Optimization of a pharmacokinetic assay in a bridging assay format using the Gyrolab immunoassay platform

Spetsare, Ebba

2019.

Download full text (pdf) of Optimization of a pharmacokinetic assay in a bridging assay format using the Gyrolab immunoassay platform

PDZ Domains as Drug Targets

Christensen, Nikolaj R.; Calyseva, Jelena; Fernandes, Eduardo F. A.; Lüchow, Susanne et al.

Part of Advanced Therapeutics, 2019.

DOI for PDZ Domains as Drug Targets

Production and characterization of LSD1 and LSD2 for fragment based drug discovery

Lúðvíksdóttir, Hildur

2019.

Download full text (pdf) of Production and characterization of LSD1 and LSD2 for fragment based drug discovery

Relative Binding Energies Predict Crystallographic Binding Modes of Ethionamide Booster Lead Compounds

Tatum, Natalie J.; Duarte, Fernanda; Kamerlin, Shina C. Lynn; Pohl, Ehmke

Part of Journal of Physical Chemistry Letters, p. 2244-2249, 2019.

DOI for Relative Binding Energies Predict Crystallographic Binding Modes of Ethionamide Booster Lead Compounds Download full text (pdf) of Relative Binding Energies Predict Crystallographic Binding Modes of Ethionamide Booster Lead Compounds

Spectral Variability in Phycocyanin Cryptophyte Antenna Complexes is Controlled by Changes in the alpha-Polypeptide Chains

Corbella, Marina; Cupellini, Lorenzo; Lipparini, Filippo; Scholes, Gregory D. et al.

Part of ChemPhotoChem, p. 945-956, 2019.

DOI for Spectral Variability in Phycocyanin Cryptophyte Antenna Complexes is Controlled by Changes in the alpha-Polypeptide Chains

Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies

Ge, Changrong; Xu, Bingze; Liang, Bibo; Lönnblom, Erik et al.

Part of Arthritis & Rheumatology, p. 210-221, 2019.

DOI for Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies

Structural Changes of Mercaptohexanol Self-assembled Monolayers on Gold and their Influence on Impedimetric Aptamer Sensors

Xu, Xingxing; Makaraviciute, Asta; Kumar, Shalen; Wen, Chenyu et al.

Part of Analytical Chemistry, p. 14697-14704, 2019.

DOI for Structural Changes of Mercaptohexanol Self-assembled Monolayers on Gold and their Influence on Impedimetric Aptamer Sensors

Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon

Parkash, Vimal; Kulkarni, Yashraj; ter Beek, Josy; Shcherbakova, Polina V. et al.

Part of Nature Communications, 2019.

DOI for Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon Download full text (pdf) of Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon

Systematic identification of recognition motifs for the hub protein LC8

Jespersen, Nathan; Estelle, Aidan; Waugh, Nathan; Davey, Norman E. et al.

Part of Life Science Alliance, 2019.

DOI for Systematic identification of recognition motifs for the hub protein LC8 Download full text (pdf) of Systematic identification of recognition motifs for the hub protein LC8

The role of ligand-gated conformational changes in enzyme catalysis

Moreira, Catia; Calixto, Ana R.; Richard, John P.; Kamerlin, Shina Caroline Lynn

Part of Biochemical Society Transactions, p. 1449-1460, 2019.

DOI for The role of ligand-gated conformational changes in enzyme catalysis Download full text (pdf) of The role of ligand-gated conformational changes in enzyme catalysis

Uncovering the Role of Key Active-Site Side Chains in Catalysis: An Extended Brønsted Relationship for Substrate Deprotonation Catalyzed by Wild-Type and Variants of Triosephosphate Isomerase

Kulkarni, Yashraj; Amyes, Tina L.; Richard, John P.; Kamerlin, Shina C. Lynn

Part of Journal of the American Chemical Society, p. 16139-16150, 2019.

DOI for Uncovering the Role of Key Active-Site Side Chains in Catalysis: An Extended Brønsted Relationship for Substrate Deprotonation Catalyzed by Wild-Type and Variants of Triosephosphate Isomerase Download full text (pdf) of Uncovering the Role of Key Active-Site Side Chains in Catalysis: An Extended Brønsted Relationship for Substrate Deprotonation Catalyzed by Wild-Type and Variants of Triosephosphate Isomerase

Unveiling the Biochemistry of the Epigenetic Regulator SMYD3

Fabini, Edoardo; Talibov, Vladimir O; Mihalic, Filip; Naldi, Marina et al.

Part of Biochemistry, p. 3634-3645, 2019.

DOI for Unveiling the Biochemistry of the Epigenetic Regulator SMYD3

Weighing-up protein dynamics: the combination of native mass spectrometry and molecular dynamics simulations

Marklund, Erik; Benesch, Justin L. P.

Part of Current opinion in structural biology, p. 50-58, 2019.

DOI for Weighing-up protein dynamics: the combination of native mass spectrometry and molecular dynamics simulations Download full text (pdf) of Weighing-up protein dynamics: the combination of native mass spectrometry and molecular dynamics simulations

A flow-through nanoporous alumina trypsin bioreactor for mass spectrometry peptide fingerprinting

Kjellander, Marcus; Billinger, Erika; Ramachandraiah, Harisha; Boman, Mats et al.

Part of Journal of Proteomics, p. 165-172, 2018.

DOI for A flow-through nanoporous alumina trypsin bioreactor for mass spectrometry peptide fingerprinting

A subset of functional adaptation mutations alter propensity for alpha-helical conformation in the intrinsically disordered glucocorticoid receptor taulcore activation domain

Salamanova, Evdokiya; Costeira-Paulo, Joana; Han, Kyou-Hoon; Kim, Do-Hyoung et al.

Part of Biochimica et Biophysica Acta - General Subjects, p. 1452-1461, 2018.

DOI for A subset of functional adaptation mutations alter propensity for alpha-helical conformation in the intrinsically disordered glucocorticoid receptor taulcore activation domain

Bringing Molecular Dynamics and Ion-Mobility Spectrometry Closer Together: Shape Correlations, Structure-Based Predictors, and Dissociation

Kulesza, Alexander; Marklund, Erik; MacAleese, Luke; Chirot, Fabien et al.

Part of Journal of Physical Chemistry B, p. 8317-8329, 2018.

DOI for Bringing Molecular Dynamics and Ion-Mobility Spectrometry Closer Together: Shape Correlations, Structure-Based Predictors, and Dissociation

Purg, Miha

Computational Modeling of the Mechanisms and Selectivity of Organophosphate Hydrolases

2018.

Download full text (pdf) of Purg, Miha

Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism

Maurer, Dirk; Lohkamp, Bernhard; Krumpel, Michael; Widersten, Mikael et al.

Part of Biochemical Journal, p. 2395-2416, 2018.

DOI for Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism

Debate on academic freedom and open access is healthy

Holbrook, J. Britt; Curry, Stephen; Kamerlin, Shina C. L.

Part of Nature, p. 494-494, 2018.

DOI for Debate on academic freedom and open access is healthy

Directed Evolution of Alcohol Dehydrogenase for Improved Stereoselective Redox Transformations of 1-Phenylethane-1,2-Diol and Its Corresponding Acyloin

Hamnevik, Emil; Maurer, Dirk; Enugala, Thilak Reddy; Chu, Thao et al.

Part of Biochemistry, p. 1059-1062, 2018.

DOI for Directed Evolution of Alcohol Dehydrogenase for Improved Stereoselective Redox Transformations of 1-Phenylethane-1,2-Diol and Its Corresponding Acyloin

Effect of transfection reagents on plasmid promoters

Lu, Yi

2018.

Download full text (pdf) of Effect of transfection reagents on plasmid promoters

Effects of conformational dynamics on enzyme evolution in TIM-barrel-fold proteins

Petrovic, Dusan; Kamerlin, Shina C. Lynn

Part of Abstracts of Papers of the American Chemical Society, 2018.

Empirical Valence Bond Simulations of Organophosphate Hydrolysis: Theory and Practice

Purg, Miha; Kamerlin, Shina C. Lynn

Part of PHOSPHATASES, p. 3-51, 2018.

DOI for Empirical Valence Bond Simulations of Organophosphate Hydrolysis: Theory and Practice

Enhancing the Steroid Sulfatase Activity of the Arylsulfatase from Pseudomonas aeruginosa

Uduwela, Dimanthi R.; Pabis, Anna; Stevenson, Bradley J.; Kamerlin, Shina C. Lynn et al.

Part of ACS Catalysis, p. 8902-8914, 2018.

DOI for Enhancing the Steroid Sulfatase Activity of the Arylsulfatase from Pseudomonas aeruginosa

Epoxide Hydrolysis as a Model System for Understanding Flux Through a Branched Reaction Scheme

Janfalk Carlsson, Åsa; Bauer, Paul; Dobritzsch, Doreen; Kamerlin, Shina C Lynn et al.

Part of IUCrJ, p. 269-282, 2018.

DOI for Epoxide Hydrolysis as a Model System for Understanding Flux Through a Branched Reaction Scheme Download full text (pdf) of Epoxide Hydrolysis as a Model System for Understanding Flux Through a Branched Reaction Scheme

Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset

Miton, Charlotte M.; Jonas, Stefanie; Fischer, Gerhard; Duarte, Fernanda et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. E7293-E7302, 2018.

DOI for Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset

Fundamentals of ion mobility spectrometry

Gabelica, Valérie; Marklund, Erik

Part of Current opinion in chemical biology, p. 51-59, 2018.

DOI for Fundamentals of ion mobility spectrometry

Genome sequencing reveals a novel genetic mechanism underlying dihydropyrimidine dehydrogenase deficiency: A novel missense variant c.1700G > A and a large intragenic inversion in DPYD spanning intron 8 to intron 12

van Kuilenburg, André; Tarailo-Graovac, Maja; Meijer, Judith; Drogemoller, Britt et al.

Part of Human Mutation, p. 947-953, 2018.

DOI for Genome sequencing reveals a novel genetic mechanism underlying dihydropyrimidine dehydrogenase deficiency: A novel missense variant c.1700G > A and a large intragenic inversion in DPYD spanning intron 8 to intron 12

High-throughput discovery of functional disordered regions

Ali, Muhammad; Ivarsson, Ylva

Part of Molecular Systems Biology, 2018.

DOI for High-throughput discovery of functional disordered regions

In Silico-Directed Evolution Using CADEE

Amrein, Beat Anton; Runthala, Ashish; Kamerlin, Shina C. Lynn

Part of Computational Methods in Protein Evolution, p. 381-415, 2018.

DOI for In Silico-Directed Evolution Using CADEE

Kinetic studies of serine protease inhibitors in simple and rapid 'active barrier' model systems: Diffusion through an inhibitor barrier

Billinger, Erika; Johansson, Gunnar

Part of Analytical Biochemistry, p. 43-49, 2018.

DOI for Kinetic studies of serine protease inhibitors in simple and rapid 'active barrier' model systems: Diffusion through an inhibitor barrier

Legend of a perfect enzyme: Active site architecture and loop dynamics in triosephosphate isomerase

Petrovic, Dusan; Kamerlin, Shina C. Lynn

Part of Abstracts of Papers of the American Chemical Society, 2018.

Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase

Costeira-Paulo, Joana; Gault, Joseph; Popova, Gergana; Ladds, Marcus J G W et al.

Part of Cell Chemical Biology, p. 309-317, 2018.

DOI for Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase Download full text (pdf) of Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase

Loop Motion in Triosephosphate Isomerase Is Not a Simple Open and Shut Case

Liao, Qinghua; Kulkarni, Yashraj; Sengupta, Ushnish; Petrovic, Dusan et al.

Part of Journal of the American Chemical Society, p. 15889-15903, 2018.

DOI for Loop Motion in Triosephosphate Isomerase Is Not a Simple Open and Shut Case Download full text (pdf) of Loop Motion in Triosephosphate Isomerase Is Not a Simple Open and Shut Case

Mass Spectrometry Reveals the Direct Action of a Chemical Chaperone

Gault, Joseph; Lianoudaki, Danai; Kaldmäe, Margit; Kronqvist, Nina et al.

Part of Journal of Physical Chemistry Letters, p. 4082-4086, 2018.

DOI for Mass Spectrometry Reveals the Direct Action of a Chemical Chaperone Download full text (pdf) of Mass Spectrometry Reveals the Direct Action of a Chemical Chaperone

Molecular modeling of conformational dynamics and its role in enzyme evolution

Petrovic, Dusan; Kamerlin, Shina C. Lynn

Part of Current opinion in structural biology, p. 50-57, 2018.

DOI for Molecular modeling of conformational dynamics and its role in enzyme evolution Download full text (pdf) of Molecular modeling of conformational dynamics and its role in enzyme evolution

New Stereoselective Biocatalysts for Carboligation and Retro-Aldol Cleavage Reactions Derived from D-Fructose 6-Phosphate Aldolase

Ma, Huan; Engel, Sarah; Enugala, Thilak Reddy; Al-Smadi, Derar et al.

Part of Biochemistry, p. 5877-5885, 2018.

DOI for New Stereoselective Biocatalysts for Carboligation and Retro-Aldol Cleavage Reactions Derived from D-Fructose 6-Phosphate Aldolase

Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors

Pandya, Nikhil J; Seeger, Christian; Babai, Norbert; Gonzalez-Lozano, Miguel A et al.

Part of Cell reports, p. 1218-1230, 2018.

DOI for Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors Download full text (pdf) of Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors

Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold

Belfrage, Anna Karin; Abdurakhmanov, Eldar; Åkerblom, Eva; Brandt, Peter et al.

Part of European Journal of Medicinal Chemistry, p. 453-464, 2018.

DOI for Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold

Proteome‐wide analysis of phospho‐regulated PDZ domain interactions

Sundell, Gustav; Arnold, Roland; Ali, Muhammad; Naksukpaiboon, Piangfan et al.

Part of Molecular Systems Biology, 2018.

DOI for Proteome‐wide analysis of phospho‐regulated PDZ domain interactions Download full text (pdf) of Proteome‐wide analysis of phospho‐regulated PDZ domain interactions

Quantitative mass imaging of single biological macromolecules

Young, Gavin; Hundt, Nikolas; Cole, Daniel; Fineberg, Adam et al.

Part of Science, p. 423-427, 2018.

DOI for Quantitative mass imaging of single biological macromolecules

Stereo- and Regioselectivity in Catalyzed Transformation of a 1,2-Disubstituted Vicinal Diol and the Corresponding Diketone by Wild Type and Laboratory Evolved Alcohol Dehydrogenases

Maurer, Dirk; Enugala, Thilak Reddy; Hamnevik, Emil; Bauer, Paul et al.

Part of ACS Catalysis, p. 7526-7538, 2018.

DOI for Stereo- and Regioselectivity in Catalyzed Transformation of a 1,2-Disubstituted Vicinal Diol and the Corresponding Diketone by Wild Type and Laboratory Evolved Alcohol Dehydrogenases Download full text (pdf) of Stereo- and Regioselectivity in Catalyzed Transformation of a 1,2-Disubstituted Vicinal Diol and the Corresponding Diketone by Wild Type and Laboratory Evolved Alcohol Dehydrogenases

Structural and functional aspects of the interaction partners of the small heat-shock protein in Synechocystis

Marklund, Erik G.; Zhang, Yichen; Basha, Eman; Benesch, Justin L P et al.

Part of Cell stress & chaperones (Print), p. 723-732, 2018.

DOI for Structural and functional aspects of the interaction partners of the small heat-shock protein in Synechocystis Download full text (pdf) of Structural and functional aspects of the interaction partners of the small heat-shock protein in Synechocystis

Structural and Mutagenesis Studies of the Thiamine-Dependent, Ketone-Accepting YerE from Pseudomonas protegens

Hampel, Sabrina; Steitz, Jan-Patrick; Baierl, Anna; Lehwald, Patrizia et al.

Part of ChemBioChem (Print), p. 2283-2292, 2018.

DOI for Structural and Mutagenesis Studies of the Thiamine-Dependent, Ketone-Accepting YerE from Pseudomonas protegens

Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions.

Hochberg, Georg K A; Shepherd, Dale A; Marklund, Erik G.; Santhanagoplan, Indu et al.

Part of Science, p. 930-935, 2018.

DOI for Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions.

Maurer, Dirk

Structure Function Relationships in Pyrimidine Degrading and Biocatalytic Enzymes, and Their Implications for Cancer Therapy and Green Chemistry

2018.

Download full text (pdf) of Maurer, Dirk

Synthesis of substrates for aldolase-catalyzed reactions: A comparison of methods for the synthesis of substituted phenylacetaldehydes

Al-Smadi, Derar; Enugala, Thilak Reddy; Norberg, Thomas; Kihlberg, Jan et al.

Part of Synlett, p. 1187-1190, 2018.

DOI for Synthesis of substrates for aldolase-catalyzed reactions: A comparison of methods for the synthesis of substituted phenylacetaldehydes

The evolution of multiple active site configurations in a designed enzyme

Hong, Nan-Sook; Petrovic, Dusan; Lee, Richmond; Gryn'ova, Ganna et al.

Part of Nature Communications, 2018.

DOI for The evolution of multiple active site configurations in a designed enzyme Download full text (pdf) of The evolution of multiple active site configurations in a designed enzyme

The Sign of Nuclear Magnetic Resonance Chemical Shift Difference as a Determinant of the Origin of Binding Selectivity: Elucidation of the Position Dependence of Phosphorylation in Ligands Binding to Scribble PDZ1

Sundell, Gustav; Vögeli, Beat; Ivarsson, Ylva; Chi, Celestine N.

Part of Biochemistry, p. 66-71, 2018.

DOI for The Sign of Nuclear Magnetic Resonance Chemical Shift Difference as a Determinant of the Origin of Binding Selectivity: Elucidation of the Position Dependence of Phosphorylation in Ligands Binding to Scribble PDZ1 Download full text (pdf) of The Sign of Nuclear Magnetic Resonance Chemical Shift Difference as a Determinant of the Origin of Binding Selectivity: Elucidation of the Position Dependence of Phosphorylation in Ligands Binding to Scribble PDZ1

To discover and validate host response biomarkers for Mycobacterium tuberculosis testing on the GeneXpert platform

Lion, Shamiran

2018.

Sundell, Gustav

Using peptide-phage display to capture conditional motif-based interactions

2018.

Download full text (pdf) of Sundell, Gustav

A novel role for the Calcineurin phosphatase at the nuclear pore

Wigington, C. P.; Roy, J.; Damle, N. P.; Ulengin-Talkish, I. et al.

Part of Molecular Biology of the Cell, p. 3727-3727, 2017.

DOI for A novel role for the Calcineurin phosphatase at the nuclear pore

Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage

Ge, Changrong P; Tong, Dongmei R; Liang, Bibo T; Lönnblom, Erik S et al.

Part of JCI INSIGHT, 2017.

DOI for Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage

Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase

Abdurakhmanov, Eldar; Solbak, Sara Oie; Danielson, U. Helena

Part of Viruses, 2017.

DOI for Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase Download full text (pdf) of Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase

Capturing the Role of Explicit Solvent in the Dimerization of Ru-V(bda) Water Oxidation Catalysts

Zhan, Shaoqi; Martensson, Daniel; Purg, Miha; Kamerlin, Shina C. Lynn et al.

Part of Angewandte Chemie International Edition, p. 6962-6965, 2017.

DOI for Capturing the Role of Explicit Solvent in the Dimerization of Ru-V(bda) Water Oxidation Catalysts Download full text (pdf) of Capturing the Role of Explicit Solvent in the Dimerization of Ru-V(bda) Water Oxidation Catalysts

Hamnevik, Emil

Characterization and Directed Evolution of an Alcohol Dehydrogenase: A Study Towards Understanding of Three Central Aspects of Substrate Selectivity

2017.

Download full text (pdf) of Hamnevik, Emil

Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition

Solbak, Sara M.Ø.; Abdurakhmanov, Eldar; Vedeler, Anni; Danielson, U. Helena

Part of Virology Journal, 2017.

DOI for Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition Download full text (pdf) of Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition

Bauer, Paul

Computational modelling of enzyme selectivity

2017.

Download full text (pdf) of Bauer, Paul

Computational study of relative thermodynamic stability of mutant base pairs between keto, enol and deprotonated forms of guanine and thymine at DNA polymerase lambda active site

Maximoff, Sergey; Eloge, Josh; Kamerlin, Shina C. Lynn; Florian, Jan

Part of Abstracts of Papers of the American Chemical Society, 2017.

Controlling Protein Orientation in Vacuum Using Electric Fields

Marklund, Erik; Ekeberg, Tomas; Moog, Mathieu; Benesch, Justin L. P. et al.

Part of Journal of Physical Chemistry Letters, p. 4540-4544, 2017.

DOI for Controlling Protein Orientation in Vacuum Using Electric Fields Download full text (pdf) of Controlling Protein Orientation in Vacuum Using Electric Fields

Development of a novel therapeutic vaccine carrier that sustains high antibody titers against several targets simultaneously

Saupe, Falk; Reichel, Matthias; Huijbers, Elisabeth J. M.; Femel, Julia et al.

Part of The FASEB Journal, p. 1204-1214, 2017.

DOI for Development of a novel therapeutic vaccine carrier that sustains high antibody titers against several targets simultaneously

Dihydropyrimidinase deficiency in four East Asian patients due to novel and rare DPYS mutations affecting protein structural integrity and catalytic activity

Nakajima, Yoko; Meijer, Judith; Dobritzsch, Doreen; Ito, Tetsuya et al.

Part of Molecular Genetics and Metabolism, p. 216-222, 2017.

DOI for Dihydropyrimidinase deficiency in four East Asian patients due to novel and rare DPYS mutations affecting protein structural integrity and catalytic activity

Discovery of short linear motif-mediated interactions through phage display of intrinsically disordered regions of the human proteome

Davey, Norman E.; Seo, Moon-Hyeong; Yadav, Vikash Kumar; Jeon, Jouhyun et al.

Part of The FEBS Journal, p. 485-498, 2017.

DOI for Discovery of short linear motif-mediated interactions through phage display of intrinsically disordered regions of the human proteome Download full text (pdf) of Discovery of short linear motif-mediated interactions through phage display of intrinsically disordered regions of the human proteome

Effects of Detergent Micelles on Lipid Binding to Proteins in Electrospray Ionization Mass Spectrometry

Landreh, Michael; Costeira-Paulo, Joana; Gault, Joseph; Marklund, Erik et al.

Part of Analytical Chemistry, p. 7425-7430, 2017.

DOI for Effects of Detergent Micelles on Lipid Binding to Proteins in Electrospray Ionization Mass Spectrometry

Electrochemical performance of Terephthalate-Functionalized Poly(3,4-ethylenedioxythiophene) conducting redox polymer

Wang, Huan; Huang, Xiao; Strømme, Maria; Sjödin, Martin

2017.

Emergence and evolution of an interaction between intrinsically disordered proteins

Hultqvist, Greta; Åberg, Emma; Camilloni, Carlo; Sundell, Gustav et al.

Part of eLIFE, 2017.

DOI for Emergence and evolution of an interaction between intrinsically disordered proteins Download full text (pdf) of Emergence and evolution of an interaction between intrinsically disordered proteins

How is substrate selectivity in hydride transfer decided in an alcohol dehydrogenase?: Directed evolution of alcohol dehydrogenase A from Rhodococcus ruber DSM 44541 through iterative saturation mutagenesis, a study to understand the structure and function relationship of enzymatic catalysis

Hillier, Heidi Therese

2017.

Download full text (pdf) of How is substrate selectivity in hydride transfer decided in an alcohol dehydrogenase?: Directed evolution of alcohol dehydrogenase A from Rhodococcus ruber DSM 44541 through iterative saturation mutagenesis, a study to understand the structure and function relationship of enzymatic catalysis

Insights from engineering the Affibody-Fc interaction with a computational-experimental method

Nosrati, Masoumeh; Solbak, Sara; Nordesjö, Olle; Nissbeck, Mikael et al.

Part of Protein Engineering Design & Selection, p. 593-601, 2017.

DOI for Insights from engineering the Affibody-Fc interaction with a computational-experimental method

Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters

Landreh, Michael; Marklund, Erik G; Uzdavinys, Povilas; Degiacomi, Matteo T. et al.

Part of Nature Communications, 2017.

DOI for Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters Download full text (pdf) of Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters

Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction

Linkuviene, V.; Talibov, Vladimir O.; Danielson, U. Helena; Matulis, D.

Part of European Biophysics Journal, p. S91-S91, 2017.

DOI for Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction

Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction

Linkuviene, V.; Talibov, Vladimir O; Danielson, U. Helena; Matulis, D.

Part of European Biophysics Journal, p. S311-S311, 2017.

DOI for Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction

Investigating the phospho-regulation of ER shaping protein RTN1A (Reticulon-1A) by the Calcineurin phosphatase.

Cho, S. Ei; Roy, J.; Ivarsson, Ylva; Cyert, M. S.

Part of Molecular Biology of the Cell, p. 3727-3727, 2017.

DOI for Investigating the phospho-regulation of ER shaping protein RTN1A (Reticulon-1A) by the Calcineurin phosphatase.

Mapping the human calcineurin phosphatase signaling network through global identification of short linear motifs that mediate substrate recognition

Roy, J.; Wigington, C. P.; Damle, N. P.; Ulengin-Talkish, I. et al.

Part of Molecular Biology of the Cell, p. 3727-3727, 2017.

DOI for Mapping the human calcineurin phosphatase signaling network through global identification of short linear motifs that mediate substrate recognition

Mass spectrometry captures structural intermediates in protein fiber self-assembly

Landreh, Michael; Andersson, Marlene; Marklund, Erik G.; Jia, Qiupin et al.

Part of Chemical Communications, p. 3319-3322, 2017.

DOI for Mass spectrometry captures structural intermediates in protein fiber self-assembly

Novel PRPS1 gain-of-function mutation in a patient with congenital hyperuricemia and facial anomalies

Porrmann, Joseph; Betcheva-Krajcir, Elitza; Di Donato, Nataliya; Kahlert, Anne-Karin et al.

Part of American Journal of Medical Genetics. Part A, p. 2736-2742, 2017.

DOI for Novel PRPS1 gain-of-function mutation in a patient with congenital hyperuricemia and facial anomalies

PP2A-B' holoenzyme substrate recognition, regulation and role in cytokinesis

Wu, Cheng-Guo; Chen, Hui; Guo, Feng; Yadav, Vikash K et al.

Part of Cell Discovery, 2017.

DOI for PP2A-B' holoenzyme substrate recognition, regulation and role in cytokinesis Download full text (pdf) of PP2A-B' holoenzyme substrate recognition, regulation and role in cytokinesis

Relaxation of Nonproductive Binding and Increased Rate of Coenzyme Release in an Alcohol Dehydrogenase Increases Turnover With a Non-Preferred Alcohol Enantiomer

Hamnevik, Emil; Enugala, Thilak Reddy; Maurer, Dirk; Ntuku, Siphosethu et al.

Part of The FEBS Journal, p. 3895-3914, 2017.

DOI for Relaxation of Nonproductive Binding and Increased Rate of Coenzyme Release in an Alcohol Dehydrogenase Increases Turnover With a Non-Preferred Alcohol Enantiomer Download full text (pdf) of Relaxation of Nonproductive Binding and Increased Rate of Coenzyme Release in an Alcohol Dehydrogenase Increases Turnover With a Non-Preferred Alcohol Enantiomer

Severe fluoropyrimidine toxicity due to novel and rare DPYD missense mutations, deletion and genomic amplification affecting DPD activity and mRNA splicing

van Kuilenburg, André B P; Meijer, Judith; Maurer, Dirk; Dobritzsch, Doreen et al.

Part of Biochimica et Biophysica Acta, p. 721-730, 2017.

DOI for Severe fluoropyrimidine toxicity due to novel and rare DPYD missense mutations, deletion and genomic amplification affecting DPD activity and mRNA splicing

Uncovering Novel Substrates and Functions for the Calcineurin Phosphatase in Human Cells

Wigington, Callie P.; Roy, Jagoree; Damle, Nikhil P.; El Cho, Shein et al.

Part of The FASEB Journal, 2017.

Yield optimization within pharmaceutical production

Erik, Gioeli

2017.

Download full text (pdf) of Yield optimization within pharmaceutical production

Biophysics in drug discovery: impact, challenges and opportunities

Renaud, Jean-Paul; Chung, Chun-wa; Danielson, U. Helena; Egner, Ursula et al.

Part of Nature reviews. Drug discovery, p. 679-698, 2016.

DOI for Biophysics in drug discovery: impact, challenges and opportunities

Conformational Diversity and Enantioconvergence in Potato Epoxide Hydrolase 1

Bauer, Paul; Janfalk Carlsson, Åsa; Amrein, Beat A.; Dobritzsch, Doreen et al.

Part of Organic and biomolecular chemistry, p. 5639-5651, 2016.

DOI for Conformational Diversity and Enantioconvergence in Potato Epoxide Hydrolase 1 Download full text (pdf) of Conformational Diversity and Enantioconvergence in Potato Epoxide Hydrolase 1

Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease

Belfrage, Anna Karin; Abdurakhmanov, Eldar; Åkerblom, Eva; Brandt, Peter et al.

Part of Bioorganic & Medicinal Chemistry, p. 2603-2620, 2016.

DOI for Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease

Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling

Egea-Jimenez, Antonio Luis; Gallardo, Rodrigo; Garcia-Pino, Abel; Ivarsson, Ylva et al.

Part of Nature Communications, 2016.

DOI for Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling Download full text (pdf) of Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling

Improved affinity at the cost of decreased specificity: a recurring theme in PDZ-peptide interactions.

Karlsson, O Andreas; Sundell, Gustav N; Andersson, Eva; Ivarsson, Ylva et al.

Part of Scientific Reports, 2016.

DOI for Improved affinity at the cost of decreased specificity: a recurring theme in PDZ-peptide interactions. Download full text (pdf) of Improved affinity at the cost of decreased specificity: a recurring theme in PDZ-peptide interactions.

Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII

Talibov, Vladimir O; Linkuvienė, Vaida; Matulis, Daumantas; Danielson, Helena U.

Part of Journal of Medicinal Chemistry, p. 2083-2093, 2016.

DOI for Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII

Laboratory evolved enzymes provide snapshots of the development of enantioconvergence in enzyme-catalyzed epoxide hydrolysis

Janfalk Carlsson, Åsa; Bauer, Paul; Dobritzsch, Doreeen; Nilsson, Mikael et al.

Part of ChemBioChem (Print), p. 1693-1697, 2016.

DOI for Laboratory evolved enzymes provide snapshots of the development of enantioconvergence in enzyme-catalyzed epoxide hydrolysis Download full text (pdf) of Laboratory evolved enzymes provide snapshots of the development of enantioconvergence in enzyme-catalyzed epoxide hydrolysis

Let There Be Light!

Raykova, Doroteya; Koos, Bjoern; Asplund, Anna; Gelleri, Marton et al.

Part of Proteomes, 2016.

DOI for Let There Be Light! Download full text (pdf) of Let There Be Light!

Linking coupled motions and entropic effects to the catalytic activity of 2-deoxyribose-5-phosphate aldolase (DERA)

Ma, Huan; Szeler, Klaudia; Kamerlin, Shina Caroline Lynn; Widersten, Mikael

Part of Chemical Science, p. 1415-1421, 2016.

DOI for Linking coupled motions and entropic effects to the catalytic activity of 2-deoxyribose-5-phosphate aldolase (DERA) Download full text (pdf) of Linking coupled motions and entropic effects to the catalytic activity of 2-deoxyribose-5-phosphate aldolase (DERA)

Pooled screening for antiproliferative inhibitors of protein-protein interactions.

Nim, Satra; Jeon, Jouhyun; Corbi-Verge, Carles; Seo, Moon-Hyeong et al.

Part of Nature Chemical Biology, p. 275-281, 2016.

DOI for Pooled screening for antiproliferative inhibitors of protein-protein interactions.

Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin

Garrido-Urbani, Sarah; Garg, Pankaj; Ghossoub, Rania; Arnold, Roland et al.

Part of FEBS Letters, p. 3-12, 2016.

DOI for Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin Download full text (pdf) of Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin

Uncovering novel substrates and functions for the calcineurin phosphatase in human cells.

Wigington, C. P.; Damle, N. P.; Roy, J.; Cho, S. E. et al.

Part of Molecular Biology of the Cell, 2016.

DOI for Uncovering novel substrates and functions for the calcineurin phosphatase in human cells.

A micro-plate format assay for real-time screening for new aldolases accepting aryl-substituted acceptor substrates

Ma, Huan; Enugala, Thilak Reddy; Widersten, Mikael

Part of ChemBioChem (Print), p. 2595-2598, 2015.

DOI for A micro-plate format assay for real-time screening for new aldolases accepting aryl-substituted acceptor substrates

Ma, Huan

Aldolases for Enzymatic Carboligation: Directed Evolution and Enzyme Structure-Function Relationship Studies

2015.

Download full text (pdf) of Ma, Huan

Design of a PDZbody, a bivalent binder of the E6 protein from human papillomavirus

Karlsson, O. Andreas; Ramirez, Juan; Öberg, Daniel; Malmqvist, Tony et al.

Part of Scientific Reports, 2015.

DOI for Design of a PDZbody, a bivalent binder of the E6 protein from human papillomavirus Download full text (pdf) of Design of a PDZbody, a bivalent binder of the E6 protein from human papillomavirus

Directed evolution on FucO - structural explanations for changes in substrate scope

Dahlström, Kathe M.; Blikstad, Cecilia; Widersten, Mikael; Salminen, Tiina A.

Part of Protein Science, p. 199-200, 2015.

Abdurakhmanov, Eldar

Discovery and evaluation of direct acting antivirals against hepatitis C virus

2015.

Download full text (pdf) of Abdurakhmanov, Eldar

Evolution of the active site of human glutathione transferase A2-2 for enhanced activity with dietary isothiocyanates

Zhang, Wei; Dourado, Daniel F. A. R.; Mannervik, Bengt

Part of Biochimica et Biophysica Acta - General Subjects, p. 742-749, 2015.

DOI for Evolution of the active site of human glutathione transferase A2-2 for enhanced activity with dietary isothiocyanates

Expanding the catalytic triad in epoxide hydrolases and related enzymes

Amrein, Beat A.; Bauer, Paul; Duarte, Fernanda; Janfalk Carlsson, Åsa et al.

Part of ACS Catalysis, p. 5702-5713, 2015.

DOI for Expanding the catalytic triad in epoxide hydrolases and related enzymes Download full text (pdf) of Expanding the catalytic triad in epoxide hydrolases and related enzymes

High-throughput methods for identification of protein-protein interactions involving short linear motifs

Blikstad, Cecilia; Ivarsson, Ylva

Part of Cell Communication and Signaling, 2015.

DOI for High-throughput methods for identification of protein-protein interactions involving short linear motifs Download full text (pdf) of High-throughput methods for identification of protein-protein interactions involving short linear motifs

Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes

Lindgren, Cecilia; Andersson, Ida E.; Berg, Lotta; Dobritzsch, Doreen et al.

Part of Organic and biomolecular chemistry, p. 6203-6216, 2015.

DOI for Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes Download full text (pdf) of Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes

Inhibitory effects of ethacrynic acid on glutathione S-transferase A1-1 from Callithrix jacchus

Aksoy, N. H.; Mannervik, B.

Part of The FEBS Journal, p. 348-348, 2015.

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the alpha 7 nicotinic acetylcholine receptor

Spurny, Radovan; Debaveye, Sarah; Farinha, Ana; Veys, Ken et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. E2543-E2552, 2015.

DOI for Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the alpha 7 nicotinic acetylcholine receptor

Molecular Interaction Analysis for Discovery of Drugs Targeting Enzymes and for Resolving Biological Function

Danielson, U. Helena

Part of Multifaceted Roles Of Crystallography In Modern Drug Discovery, p. 223-240, 2015.

DOI for Molecular Interaction Analysis for Discovery of Drugs Targeting Enzymes and for Resolving Biological Function

Novel approach to radionuclide therapy of cancer: affibody-based bio-orthogonal chemistry mediated pretargeting

Tsourma, Maria

2015.

Download full text (pdf) of Novel approach to radionuclide therapy of cancer: affibody-based bio-orthogonal chemistry mediated pretargeting

Positional Identification of RT1-B (HLA-DQ) as Susceptibility Locus for Autoimmune Arthritis

Haag, Sabrina; Tuncel, Jonatan; Thordardottir, Soley; Mason, Daniel E. et al.

Part of Journal of Immunology, p. 2539-2550, 2015.

DOI for Positional Identification of RT1-B (HLA-DQ) as Susceptibility Locus for Autoimmune Arthritis

Proximity-dependent initiation of hybridization chain reaction

Koos, Björn; Cane, Gaëlle; Grannas, Karin; Löf, Liza et al.

Part of Nature Communications, 2015.

DOI for Proximity-dependent initiation of hybridization chain reaction Download full text (pdf) of Proximity-dependent initiation of hybridization chain reaction

Selectivity of Aggregation-Determining Interactions

Ganesan, Ashok; Debulpaep, Maja; Wilkinson, Hannah; Van Durme, Joost et al.

Part of Journal of Molecular Biology, p. 236-247, 2015.

DOI for Selectivity of Aggregation-Determining Interactions

Structural basis of Sorcin-mediated calcium-dependent signal transduction

Ilari, Andrea; Fiorillo, Annarita; Poser, Elena; Lalioti, Vasiliki S. et al.

Part of Scientific Reports, 2015.

DOI for Structural basis of Sorcin-mediated calcium-dependent signal transduction Download full text (pdf) of Structural basis of Sorcin-mediated calcium-dependent signal transduction

Structural basis of Sorcin-mediated calcium-dependent signal transduction

Ilari, Andrea; Fiorillo, Annarita; Poser, Elena; Lalioti, Vasiliki S. et al.

Part of Scientific Reports, 2015.

An unprecedented rearrangement of a 1,1-diprotected hydrazine derivative. Structure revision of a catalyst-containing by-product

Ragnarsson, Ulf; Grehn, Leif; Pehk, Tonis

Part of Tetrahedron Letters, p. 7019-7022, 2014.

DOI for An unprecedented rearrangement of a 1,1-diprotected hydrazine derivative. Structure revision of a catalyst-containing by-product

Clinical, biochemical and molecular analysis of 13 Japanese patients with beta-ureidopropionase deficiency demonstrates high prevalence of the c.977G > A (p.R326Q) mutation

Nakajima, Yoko; Meijer, Judith; Dobritzsch, Doreen; Ito, Tetsuya et al.

Part of Journal of Inherited Metabolic Disease, p. 801-812, 2014.

DOI for Clinical, biochemical and molecular analysis of 13 Japanese patients with beta-ureidopropionase deficiency demonstrates high prevalence of the c.977G > A (p.R326Q) mutation Download full text (pdf) of Clinical, biochemical and molecular analysis of 13 Japanese patients with beta-ureidopropionase deficiency demonstrates high prevalence of the c.977G > A (p.R326Q) mutation

Directed Evolution of ADH-A from Rhodococcus ruber DSM 44541

Bauer, Paul

2014.

Download full text (pdf) of Directed Evolution of ADH-A from Rhodococcus ruber DSM 44541

Epitope-specific antibody response is controlled by immunoglobuline V_H polymorphisms

Raposo, Bruno; Dobritzsch, Doreen; Ge, Changrong; Ekman, Diana et al.

Part of Journal of Experimental Medicine, p. 405-411, 2014.

DOI for Epitope-specific antibody response is controlled by immunoglobuline V_H polymorphisms

Furaldehyde substrate specificity and kinetics of Saccharomyces cerevisiae alcohol dehydrogenase 1 variants

Laadan, B.; Wallace-Salinas, V.; Janfalk Carlsson, Åsa; Almeida, J. et al.

Part of Microbial Cell Factories, p. 112-, 2014.

DOI for Furaldehyde substrate specificity and kinetics of Saccharomyces cerevisiae alcohol dehydrogenase 1 variants Download full text (pdf) of Furaldehyde substrate specificity and kinetics of Saccharomyces cerevisiae alcohol dehydrogenase 1 variants

Glutathione transferases immobilized on nanoporous alumina: Flow system kinetics, screening and stability

Kjellander, Marcus; Mazari, Aslam M.A.; Boman, Mats; Mannervik, Bengt et al.

Part of Analytical Biochemistry, p. 59-63, 2014.

DOI for Glutathione transferases immobilized on nanoporous alumina: Flow system kinetics, screening and stability

Glutathione Transferases in the Bioactivation of Azathioprine

Modén, Olof; Mannervik, Bengt

Part of REDOX AND CANCER PT A, p. 199-244, 2014.

DOI for Glutathione Transferases in the Bioactivation of Azathioprine

Identification and characterization of an irreversible inhibitor of CDK2

Martin, M.; Anscombe, E.; Meschini, E.; Staunton, D. et al.

Part of European Journal of Cancer, p. 106-106, 2014.

DOI for Identification and characterization of an irreversible inhibitor of CDK2

In situ generation of iminodiacetic acid groups on nanoporous alumina for the reversible immobilization of enzymes and other biomolecules

Berglin, Lennart; Kjellander, Marcus; Johansson, Gunnar

Part of Biotechnology letters, p. 1819-1825, 2014.

DOI for In situ generation of iminodiacetic acid groups on nanoporous alumina for the reversible immobilization of enzymes and other biomolecules

Interaction Analysis through Proteomic Phage Display

Sundell, Gustav; Ivarsson, Ylva

Part of BioMed Research International, p. 176172-, 2014.

DOI for Interaction Analysis through Proteomic Phage Display Download full text (pdf) of Interaction Analysis through Proteomic Phage Display

Isomerization of Delta(5)-Androstene-3,17-dione into Delta(4)-Androstene-3, 17-dione Catalyzed by Human Glutathione Transferase A3-3: A Computational Study Identifies a Dual Role for Glutathione

Dourado, Daniel F. A. R.; Fernandes, Pedro Alexandrino; Mannervik, Bengt; Ramos, Maria Joao

Part of Journal of Physical Chemistry A, p. 5790-5800, 2014.

DOI for Isomerization of Delta(5)-Androstene-3,17-dione into Delta(4)-Androstene-3, 17-dione Catalyzed by Human Glutathione Transferase A3-3: A Computational Study Identifies a Dual Role for Glutathione

Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Lampa, Anna; Bergman, Sara; Svahn Gustafsson, Sofia; Alogheli, Hiba et al.

Part of ACS Medicinal Chemistry Letters, p. 249-254, 2014.

DOI for Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Ehrenberg, Angelica

Novel Procedures for Identification and Characterization of Viral Proteases Inhibitors

2014.

Download full text (pdf) of Ehrenberg, Angelica

Seeger, Christian

Revealing Secrets of Synaptic Protein Interactions: A Biosensor based Strategy

2014.

Download full text (pdf) of Seeger, Christian

Steady state kinetics and regioselectivity for variants of StEH1 hydrolyzing different epoxide substrates

Toresson, Henrik

2014.

Download full text (pdf) of Steady state kinetics and regioselectivity for variants of StEH1 hydrolyzing different epoxide substrates

Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme

Dobritzsch, Doreen; Wang, Huaming; Schneider, Gunter; Yu, Shukun

Part of Biochemical Journal, p. 441-452, 2014.

DOI for Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme

Substrate scope and selectivity in offspring to an enzyme subjected to directed evolution

Blikstad, Cecilia; Dahlström, Käthe; Salminen, Tiina; Widersten, Mikael

Part of The FEBS Journal, p. 2387-2398, 2014.

DOI for Substrate scope and selectivity in offspring to an enzyme subjected to directed evolution

The Development and Characterization of a Peptide-Based Syntenin Inhibitor: Implacations for Cancer Metastasis

Haugaard-Kedstrom, L. M.; Albertsen, L.; Gil, F. Abalde; Ivarsson, Ylva et al.

Part of Journal of Peptide Science, p. S39-S39, 2014.

The Versatile Nature of the 6-Aminoquinolone Scaffold: Identification of Submicromolar Hepatitis C Virus NS5B Inhibitors

Manfroni, Giuseppe; Cannalire, Rolando; Barreca, Maria Letizia; Kaushik-Basu, Neerja et al.

Part of Journal of Medicinal Chemistry, p. 1952-1963, 2014.

DOI for The Versatile Nature of the 6-Aminoquinolone Scaffold: Identification of Submicromolar Hepatitis C Virus NS5B Inhibitors

Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Lampa, Anna; Alogheli, Hiba; Ehrenberg, Angelica E.; Åkerblom, Eva et al.

Part of Bioorganic & Medicinal Chemistry, p. 6595-6615, 2014.

DOI for Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

An improved dual-tube megaprimer approach for multi-site saturation mutagenesis

Zhang, Wei; Mannervik, Bengt

Part of World Journal of Microbiology & Biotechnology, p. 667-672, 2013.

DOI for An improved dual-tube megaprimer approach for multi-site saturation mutagenesis

Dual protection of amino functions involving Boc

Ragnarsson, Ulf; Grehn, Leif

Part of RSC Advances, p. 18691-18697, 2013.

DOI for Dual protection of amino functions involving Boc Download full text (pdf) of Dual protection of amino functions involving Boc

Efficient Screening of Marine Extracts for Protease Inhibitors by Combining FRET Based Activity Assays and Surface Plasmon Resonance Spectroscopy Based Binding Assays

Christopeit, Tony; Øverbø, Kersti; Danielson, Helena; Nilsen, Inge W.

Part of Marine Drugs, p. 4279-4293, 2013.

DOI for Efficient Screening of Marine Extracts for Protease Inhibitors by Combining FRET Based Activity Assays and Surface Plasmon Resonance Spectroscopy Based Binding Assays Download full text (pdf) of Efficient Screening of Marine Extracts for Protease Inhibitors by Combining FRET Based Activity Assays and Surface Plasmon Resonance Spectroscopy Based Binding Assays

Evolution of Broad Spectrum beta-Lactam Resistance in an Engineered Metallo-beta-lactamase

Sun, Song; Zhang, Wei; Mannervik, Bengt; Andersson, Dan I.

Part of Journal of Biological Chemistry, p. 2314-2324, 2013.

DOI for Evolution of Broad Spectrum beta-Lactam Resistance in an Engineered Metallo-beta-lactamase

FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1

Musdal, Yaman; Hegazy, Usama M.; Aksoy, Yasemin; Mannervik, Bengt

Part of Chemico-Biological Interactions, p. 53-62, 2013.

DOI for FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1

Fluorogenic probes using 4-substituted-2-nitrobenzenesulfonyl derivatives as caging groups for the analysis of human glutathione transferase catalyzed reactions

Shibata, Aya; Nakano, Yukiko; Ito, Mika; Araki, Mika et al.

Part of The Analyst, p. 7326-7330, 2013.

DOI for Fluorogenic probes using 4-substituted-2-nitrobenzenesulfonyl derivatives as caging groups for the analysis of human glutathione transferase catalyzed reactions

Nordström, Helena

Fragment Based Drug Discovery with Surface Plasmon Resonance Technology

2013.

Download full text (pdf) of Nordström, Helena

Gene Expression Deregulation in Postnatal Skeletal Muscle of TK2 Deficient Mice Reveals a Lower Pool of Proliferating Myogenic Progenitor Cells

Paredes, J. A.; Zhou, X.; Höglund, Stefan; Karlsson, A.

Part of PLOS ONE, p. e53698-, 2013.

DOI for Gene Expression Deregulation in Postnatal Skeletal Muscle of TK2 Deficient Mice Reveals a Lower Pool of Proliferating Myogenic Progenitor Cells Download full text (pdf) of Gene Expression Deregulation in Postnatal Skeletal Muscle of TK2 Deficient Mice Reveals a Lower Pool of Proliferating Myogenic Progenitor Cells

Identification of Structural-Kinetic and Structural-Thermodynamic Relationships for Thrombin Inhibitors

Winquist, Johan; Geschwindner, Stefan; Xue, Yafeng; Gustavsson, Lars et al.

Part of Biochemistry, p. 613-626, 2013.

DOI for Identification of Structural-Kinetic and Structural-Thermodynamic Relationships for Thrombin Inhibitors

In Search of Catalytic Antioxidants-(Alkyltelluro)phenols, (Alkyltelluro)resorcinols, and Bis(alkyltelluro)phenols

Poon, Jia-fei; Singh, Vijay P.; Engman, Lars

Part of Journal of Organic Chemistry, p. 6008-6015, 2013.

DOI for In Search of Catalytic Antioxidants-(Alkyltelluro)phenols, (Alkyltelluro)resorcinols, and Bis(alkyltelluro)phenols

Mechanism of Glutathione Transferase P1-1-Catalyzed Activation of the Prodrug Canfosfamide (TLK286, TELCYTA)

Dourado, Daniel F. A. R.; Fernandes, Pedro Alexandrino; Ramos, Maria Joao; Mannervik, Bengt

Part of Biochemistry, p. 8069-8078, 2013.

DOI for Mechanism of Glutathione Transferase P1-1-Catalyzed Activation of the Prodrug Canfosfamide (TLK286, TELCYTA)

Modén, Olof

Mutational Analysis and Redesign of Alpha-class Glutathione Transferases for Enhanced Azathioprine Activity

2013.

Download full text (pdf) of Modén, Olof

Kjellander, Marcus

Nanoporous Aluminum Oxide – A Promising Support for Modular Enzyme Reactors

2013.

Download full text (pdf) of Kjellander, Marcus

Novel assay formats for improved immunoassay sensitivity in a minaturised CD-microlaboratory

Löfling, Annica

2013.

Resolution of the Interaction Mechanisms and Characteristics of Non-nucleoside Inhibitors of Hepatitis C Virus Polymerase - Laying the Foundation for Discovery of Allosteric HCV Drugs

Winquist, Johan; Abdurakhmanov, Eldar; Baraznenok, Vera; Henderson, Ian et al.

Part of Antiviral Research, p. 356-368, 2013.

DOI for Resolution of the Interaction Mechanisms and Characteristics of Non-nucleoside Inhibitors of Hepatitis C Virus Polymerase - Laying the Foundation for Discovery of Allosteric HCV Drugs

Steady-state generation of hydrogen peroxide: kinetics and stability of alcohol oxidase immobilized on nanoporous alumina

Kjellander, Marcus; Gotz, Kathrin; Liljeruhm, Josefine; Boman, Mats et al.

Part of Biotechnology letters, p. 585-590, 2013.

DOI for Steady-state generation of hydrogen peroxide: kinetics and stability of alcohol oxidase immobilized on nanoporous alumina

Stereoselective oxidation of aryl-substituted vicinal diols into chiral α-hydroxy aldehydes by re-engineered propanediol oxidoreductase

Blikstad, Cecilia; Dahlström, Kärthe M.; Salminen, Tiina A.; Widersten, Mikael

Part of ACS Catalysis, p. 3016-3025, 2013.

DOI for Stereoselective oxidation of aryl-substituted vicinal diols into chiral α-hydroxy aldehydes by re-engineered propanediol oxidoreductase

Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway

Valegard, Karin; Iqbal, Aman; Kershaw, Nadia J.; Ivison, David et al.

Part of Acta Crystallographica Section D, p. 1567-1579, 2013.

Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway

Valegard, Karin; Iqbal, Aman; Kershaw, Nadia J.; Ivison, David et al.

Part of Acta Crystallographica Section D, p. 1567-1579, 2013.

Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway

Valegård, Karin; Iqbal, Aman; Kershaw, Nadia J.; Ivison, David et al.

Part of Acta Crystallographica Section D, p. 1567-1579, 2013.

DOI for Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway

Structural basis of ligand recognition in 5-HT3 receptors

Kesters, D.; Thompson, A. J.; Brams, M.; Van Elk, R. et al.

Part of EMBO Reports, p. 49-56, 2013.

DOI for Structural basis of ligand recognition in 5-HT3 receptors

Structure-Based Discovery of Pyrazolobenzothiazine Derivatives As Inhibitors of Hepatitis C Virus Replication

Barreca, Maria Letizia; Manfroni, Giuseppe; Leyssen, Pieter; Winquist, Johan et al.

Part of Journal of Medicinal Chemistry, p. 2270-2282, 2013.

DOI for Structure-Based Discovery of Pyrazolobenzothiazine Derivatives As Inhibitors of Hepatitis C Virus Replication

The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors: characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors

Gossas, Thomas; Nordström, Helena; Xu, Ming-Hua; Sun, Zhi-Hua et al.

Part of MedChemComm, p. 432-442, 2013.

DOI for The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors: characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors

AKAP79/150 interacts with the neuronal calcium-binding protein caldendrin

Gorny, Xenia; Mikhaylova, Marina; Seeger, Christian; Reddy, Pasham Parameshwar et al.

Part of Journal of Neurochemistry, p. 714-726, 2012.

DOI for AKAP79/150 interacts with the neuronal calcium-binding protein caldendrin

Aliskiren displays long-lasting interactions with human renin

Gossas, Thomas; Vrang, Lotta; Henderson, Ian; Sedig, Susanne et al.

Part of Naunyn-Schmiedeberg's Archives of Pharmacology, p. 219-224, 2012.

DOI for Aliskiren displays long-lasting interactions with human renin

Corrigendum to "Histaminergic pharmacology of homo-oligomeric β3 γ-aminobutyric acid type A receptors characterized by surface plasmon resonance biosensor technology" (Biochemical Pharmacology (2012) 84 (341-351))

Seeger, Christian; Christopeit, Tony; Fuchs, K.; Grote, K. et al.

Part of Biochemical Pharmacology, p. 1541-, 2012.

DOI for Corrigendum to "Histaminergic pharmacology of homo-oligomeric β3 γ-aminobutyric acid type A receptors characterized by surface plasmon resonance biosensor technology" (Biochemical Pharmacology (2012) 84 (341-351))

Experimental and 'in silico' analysis of the effect of pH on HIV-1 protease inhibitor affinity: Implications for the charge state of the protein ionogenic groups

Dominguez, Jose L.; Gossas, Thomas; Carmen Villaverde, M.; Danielson, U. Helena et al.

Part of Bioorganic & Medicinal Chemistry, p. 4838-4847, 2012.

DOI for Experimental and 'in silico' analysis of the effect of pH on HIV-1 protease inhibitor affinity: Implications for the charge state of the protein ionogenic groups

Exploring the active site of tripeptidyl-peptidase II through studies of pH dependence of reaction kinetics

Eklund, Sandra; Lindås, Ann-Christin; Hamnevik, Emil; Widersten, Mikael et al.

Part of Biochimica et Biophysica Acta - Proteins and Proteomics, p. 561-570, 2012.

DOI for Exploring the active site of tripeptidyl-peptidase II through studies of pH dependence of reaction kinetics

Five Decades with Glutathione and the GSTome

Mannervik, Bengt

Part of Journal of Biological Chemistry, p. 6072-6083, 2012.

DOI for Five Decades with Glutathione and the GSTome

Histaminergic pharmacology of homo-oligomeric beta 3 gamma-aminobutyric acid type A receptors characterized by surface plasmon resonance biosensor technology

Seeger, Christian; Christopeit, Tony; Fuchs, Karoline; Grote, Katharina et al.

Part of Biochemical Pharmacology, p. 341-351, 2012.

DOI for Histaminergic pharmacology of homo-oligomeric beta 3 gamma-aminobutyric acid type A receptors characterized by surface plasmon resonance biosensor technology

Inhibition of human glutathione transferase P1-1 by novel benzazole derivatives

Musdal, Y.; Ertan-Bolelli, T.; Bolelli, K.; Yilmaz, S. et al.

Part of Türk Biyokimya Dergisi, p. 431-436, 2012.

DOI for Inhibition of human glutathione transferase P1-1 by novel benzazole derivatives

Insights into sulfinate formation from tosyl hydrazides

Ragnarsson, Ulf; Grehn, Leif

Part of Tetrahedron Letters, p. 1045-1047, 2012.

DOI for Insights into sulfinate formation from tosyl hydrazides

Kinetic and mechanistic differences in the interactions between caldendrin and calmodulin with AKAP79 suggest different roles in synaptic function

Seeger, Christian; Gorny, Xenia; Reddy, Pasham Parameshwar; Seidenbecher, Constanze et al.

Part of Journal of Molecular Recognition, p. 495-503, 2012.

DOI for Kinetic and mechanistic differences in the interactions between caldendrin and calmodulin with AKAP79 suggest different roles in synaptic function

Multidimensional epistasis and fitness landscapes in enzyme evolution

Zhang, Wei; Dourado, Daniel F. A. R.; Fernandes, Pedro; Ramos, Maria et al.

Part of Biochemical Journal, p. 39-46, 2012.

DOI for Multidimensional epistasis and fitness landscapes in enzyme evolution

Mutational analysis of human glutathione transferase A2-2 identifies structural elements supporting high activity with the prodrug azathioprine

Modén, Olof; Zhang, Wei; Mannervik, Bengt

Part of Protein Engineering Design & Selection, p. 189-197, 2012.

DOI for Mutational analysis of human glutathione transferase A2-2 identifies structural elements supporting high activity with the prodrug azathioprine

Obtaining optical purity for product diols in enzyme-catalyzed epoxide hydrolysis: contributions from changes in both enantio- and regioselectivity

Janfalk Carlsson, Åsa; Bauer, Paul; Ma, Huan; Widersten, Mikael

Part of Biochemistry, p. 7627-7637, 2012.

DOI for Obtaining optical purity for product diols in enzyme-catalyzed epoxide hydrolysis: contributions from changes in both enantio- and regioselectivity

Winquist, Johan

Reducing Attrition via Improved Strategies for Pre-clinical Drug Discovery: SPR-biosensor Aided Interaction Studies

2012.

Download full text (pdf) of Winquist, Johan

Universal Caging Group for the in-Cell Detection of Glutathione Transferase Applied to 19F NMR and Bioluminogenic Probes

Ito, Mika; Shibata, Aya; Zhang, Jie; Hiroshima, Michio et al.

Part of ChemBioChem (Print), p. 1428-1432, 2012.

DOI for Universal Caging Group for the in-Cell Detection of Glutathione Transferase Applied to 19F NMR and Bioluminogenic Probes

A surface plasmon resonance-based biosensor with full-length BACE1 in a reconstituted membrane

Christopeit, Tony; Stenberg, Gun; Gossas, Thomas; Nyström, Susanne et al.

Part of Analytical Biochemistry, p. 14-22, 2011.

DOI for A surface plasmon resonance-based biosensor with full-length BACE1 in a reconstituted membrane

Biosynthesis of 14,15-Hepoxilins in Human L1236 Hodgkin Lymphoma Cells and Eosinophils

Brunnström, Åsa; Hamberg, Mats; Griffiths, William J.; Mannervik, Bengt et al.

Part of Lipids, p. 69-79, 2011.

DOI for Biosynthesis of 14,15-Hepoxilins in Human L1236 Hodgkin Lymphoma Cells and Eosinophils

Characterization of porcine Alpha-class glutathione transferase A1-1

Fedulova, Natalia; Raffalli-Mathieu, Francoise; Mannervik, Bengt

Part of Archives of Biochemistry and Biophysics, p. 205-211, 2011.

DOI for Characterization of porcine Alpha-class glutathione transferase A1-1

Deconstruction of Non-Nucleoside Reverse Transcriptase Inhibitors of Human Immunodeficiency Virus Type 1 for Exploration of the Optimization Landscape of Fragments

Brandt, Peter; Geitmann, Matthis; Danielson, U Helena

Part of Journal of Medicinal Chemistry, 2011.

DOI for Deconstruction of Non-Nucleoside Reverse Transcriptase Inhibitors of Human Immunodeficiency Virus Type 1 for Exploration of the Optimization Landscape of Fragments

Zhang, Wei

Directed Evolution of Glutathione Transferases with Altered Substrate Selectivity Profiles: A Laboratory Evolution Study Shedding Light on the Multidimensional Nature of Epistasis

2011.

Download full text (pdf) of Zhang, Wei

Experimental Conditions Affecting Functional Comparison of Highly Active Glutathione Transferases

Fedulova, Natalia; Mannervik, Bengt

Part of Analytical Biochemistry, p. 16-23, 2011.

DOI for Experimental Conditions Affecting Functional Comparison of Highly Active Glutathione Transferases

Experimental Validation of a Fragment Library for Lead Discovery Using SPR Biosensor Technology

Elinder, Malin; Geitmann, Matthis; Gossas, Thomas; Källblad, Per et al.

Part of Journal of Biomolecular Screening, p. 15-25, 2011.

DOI for Experimental Validation of a Fragment Library for Lead Discovery Using SPR Biosensor Technology

FtsZ degradation in the cyanobacterium Anabaena sp. strain PCC 7120

Lopes Pinto, Fernando; Erasmie, Sven; Blikstad, Cecilia; Lindblad, Peter et al.

Part of Journal of plant physiology (Print), p. 1934-1942, 2011.

DOI for FtsZ degradation in the cyanobacterium Anabaena sp. strain PCC 7120

Identification of a Novel Scaffold for Allosteric Inhibition of Wild Type and Drug Resistant HIV-1 Reverse Transcriptase by Fragment Library Screening

Geitmann, Matthis; Elinder, Malin; Seeger, Christian; Brandt, Peter et al.

Part of Journal of Medicinal Chemistry, p. 699-708, 2011.

DOI for Identification of a Novel Scaffold for Allosteric Inhibition of Wild Type and Drug Resistant HIV-1 Reverse Transcriptase by Fragment Library Screening

Eklund, Sandra

Interpreting a Giant: Studies of Structure and Function of Tripeptidyl-peptidase II

2011.

Download full text (pdf) of Eklund, Sandra

Mechanistic and kinetic characterization of hepatitis C virus NS3 protein interactions with NS4A and protease inhibitors

Geitmann, Matthis; Dahl, Göran; Danielson, U. Helena

Part of Journal of Molecular Recognition, p. 60-70, 2011.

DOI for Mechanistic and kinetic characterization of hepatitis C virus NS3 protein interactions with NS4A and protease inhibitors

One-step enzyme extraction and immobilization for biocatalysis applications

Cassimjee, Karim Engelmark; Kourist, Robert; Lindberg, Diana; Wittrup Larsen, Marianne et al.

Part of Biotechnology Journal, p. 463-469, 2011.

DOI for One-step enzyme extraction and immobilization for biocatalysis applications

Powerful protein binders from designed polypeptides and small organic molecules: a general concept for protein recognition

Tegler, Lotta T.; Nonglaton, Guillaume; Büttner, Frank; Caldwell, Karin et al.

Part of Angewandte Chemie International Edition, p. 1823-1827, 2011.

DOI for Powerful protein binders from designed polypeptides and small organic molecules: a general concept for protein recognition

Quantification of interactions between drug leads and serum proteins by use of "binding efficiency"

Gustafsson, Sofia S.; Vrang, Lotta; Terelius, Ylva; Danielson, Helena

Part of Analytical Biochemistry, p. 163-175, 2011.

DOI for Quantification of interactions between drug leads and serum proteins by use of "binding efficiency"

Quantitative and selective polymerase chain reaction analysis of highly similar human alpha-class glutathione transferases

Larsson, Emilia; Mannervik, Bengt; Raffalli-Mathieu, Francoise

Part of Analytical Biochemistry, p. 96-101, 2011.

DOI for Quantitative and selective polymerase chain reaction analysis of highly similar human alpha-class glutathione transferases

Deep eutectic solvents (DESs) are viable cosolvents for enzyme-catalyzed epoxide hydrolysis

Lindberg, Diana; de la Fuente Revenga, Mario; Widersten, Mikael

Part of Journal of Biotechnology, p. 169-171, 2010.

DOI for Deep eutectic solvents (DESs) are viable cosolvents for enzyme-catalyzed epoxide hydrolysis

Development of surface plasmon resonance biosensor assays for primary and secondary screening of acetylcholine binding protein ligands

Retra, Kim; Geitmann, Matthis; Kool, Jeroen; Smit, August B et al.

Part of Analytical Biochemistry, p. 58-64, 2010.

DOI for Development of surface plasmon resonance biosensor assays for primary and secondary screening of acetylcholine binding protein ligands

Discovery of Achiral Inhibitors of the Hepatitis C Virus NS3 Protease based on 2(1H)-pyrazinones

Örtqvist, Pernilla; Gising, Johan; Ehrenberg, Angelica; Vema, Aparna et al.

Part of Bioorganic & Medicinal Chemistry, p. 6512-6525, 2010.

DOI for Discovery of Achiral Inhibitors of the Hepatitis C Virus NS3 Protease based on 2(1H)-pyrazinones

Improved P2 phenylglycine-based hepatitis C virus NS3 protease inhibitors with alkenylic prime-side substituents

Lampa, Anna; Ehrenberg, Angelica E.; Gustafsson, Sofia S.; Vema, Aparna et al.

Part of Bioorganic & Medicinal Chemistry, p. 5413-5424, 2010.

DOI for Improved P2 phenylglycine-based hepatitis C virus NS3 protease inhibitors with alkenylic prime-side substituents

Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein

Geitmann, Matthis; Retra, Kim; de Kloe, Gerdien E; Homan, Evert et al.

Part of Biochemistry, p. 8143-8154, 2010.

DOI for Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein

Precautions to improve the accuracy of quantitative determinations of biomarkers in clinical diagnostics

Ghasemzadeh, Nasim; Tore W. Wilhelmsen, Tore W.; Nyberg, Fred; Hjertén, Stellan

Part of Electrophoresis, p. 2722-2729, 2010.

DOI for Precautions to improve the accuracy of quantitative determinations of biomarkers in clinical diagnostics

Structure-activity relationships of HCV NS3 protease inhibitors evaluated on the drug-resistant variants A156T and D168V

Örtqvist, Pernilla; Vema, Aparna; Ehrenberg, Angelica E; Dahl, Göran et al.

Part of Antiviral Therapy, p. 841-852, 2010.

DOI for Structure-activity relationships of HCV NS3 protease inhibitors evaluated on the drug-resistant variants A156T and D168V

Surface Plasmon Resonance Biosensor Based Fragment Screening Using Acetylcholine Binding Protein Identifies Ligand Efficiency Hot Spots (LE Hot Spots) by Deconstruction of Nicotinic Acetylcholine Receptor α7 Ligands

de Kloe, Gerdien E; Retra, Kim; Geitmann, Matthis; Källblad, Per et al.

Part of Journal of Medicinal Chemistry, p. 7192-7201, 2010.

DOI for Surface Plasmon Resonance Biosensor Based Fragment Screening Using Acetylcholine Binding Protein Identifies Ligand Efficiency Hot Spots (LE Hot Spots) by Deconstruction of Nicotinic Acetylcholine Receptor α7 Ligands

Temperature and pH dependence of enzyme catalyzed hydrolysis of trans-methylstyrene oxide: a unifying kinetic model for observed hysteresis, cooperativity and regioselectivity

Lindberg, Diana; de la Fuente Revenga, Mario; Widersten, Mikael

Part of Biochemistry, p. 2297-2304, 2010.

DOI for Temperature and pH dependence of enzyme catalyzed hydrolysis of trans-methylstyrene oxide: a unifying kinetic model for observed hysteresis, cooperativity and regioselectivity

The quest for molecular quasi-species in ligand-activity space and its application to directed enzyme evolution

Mannervik, Bengt; Rúnarsdóttir, Arna

Part of FEBS Letters, p. 2565-2571, 2010.

DOI for The quest for molecular quasi-species in ligand-activity space and its application to directed enzyme evolution

Fragment library screening and lead characterization using SPR biosensors

Danielson, U Helena

Part of Current Topics in Medicinal Chemistry, p. 1725-1735, 2009.

DOI for Fragment library screening and lead characterization using SPR biosensors

Purification and characterization of a laccase from the basidiomycete Funalia trogii (Berk.) isolated in Tanzania

Patrick, Ferdinandi; Mtui, Godliving; Mshandete, Anthony; Johansson, Gunnar et al.

Part of African Journal of Biochemistry Research, p. 250-259, 2009.

Analysis of the Surfaces of Wood Tissues and Pulp Fibers Using Carbohydrate-Binding Modules Specific for Crystalline Cellulose and Mannan

Filonova, Lada; Kallas, Åsa; Greffe, Lionel; Johansson, Gunnar et al.

Part of Biomacromolecules, p. 91-97, 2007.

Differences between bovine and human steroid double-bond isomerase activities of Alpha-class glutathione transferases selectively expressed in steroidogenic tissues

Raffalli-Mathieu, Francoise; Persson, David; Mannervik, Bengt

Part of Biochimica et Biophysica Acta - General Subjects, p. 130-136, 2007.

DOI for Differences between bovine and human steroid double-bond isomerase activities of Alpha-class glutathione transferases selectively expressed in steroidogenic tissues

Identification of a regulatory cis-element within the 3 '-untranslated region of the murine inducible nitric oxide synthase (NOS) mRNA: interaction with heterogeneous nuclear ribonucleoproteins I and L and role in the NOS gene expression

Söderberg, Malin; Raffalli-Mathieu, Françoise; Lang, Matti A.

Part of Molecular Immunology, p. 434-442, 2007.

DOI for Identification of a regulatory cis-element within the 3 '-untranslated region of the murine inducible nitric oxide synthase (NOS) mRNA: interaction with heterogeneous nuclear ribonucleoproteins I and L and role in the NOS gene expression

Investigation of beta-amino acids as building blocks in hepatitis c virus NS3 protease inhibitors

Nurbo, Johanna; Dahl, G; Danielson, U Helena; Sandström, Anja

2007.

Mutation in the loop C-terminal to the cyclophilin A binding site of HIV-1 capsid protein disrupts proper virus assembly and infectivity

Abdurahman, Samir; Höglund, Stefan; Höglund, Anders; Vahlne, Anders

Part of Retrovirology, p. 19-, 2007.

DOI for Mutation in the loop C-terminal to the cyclophilin A binding site of HIV-1 capsid protein disrupts proper virus assembly and infectivity

A positively selected residue influences enzyme functionalities

Ivarsson, Ylva; Norrgård, Malena A; Tars, Kaspar; Mannervik, Bengt

Part of The FASEB Journal, p. A474-, 2006.

Design and evolution of new catalytic activity with an existing protein scaffold.

Park, Hee-Sung; Nam, Sung-Hun; Lee, Jin Kak; Yoon, Chang No et al.

Part of Science, p. 535-8, 2006.

Identification of functionally diverging quasi-species in molecular enzyme evolution

Kurtovic, Sanela; Emrén, Lars O; Runarsdottír, Arna; Larsson, Anna-Karin et al.

Part of The FASEB Journal, p. A470-, 2006.

In vivo and mechanistic evidence of nuclear receptor CAR induction by artemisinin

Simonsson, Ulrika S.H.; Lindell, Monica; Raffalli-Mathieu, Francoise; Lannerbro, Angela et al.

Part of European Journal of Clinical Investigation, p. 647-653, 2006.

DOI for In vivo and mechanistic evidence of nuclear receptor CAR induction by artemisinin

Inhibition of viral proteases by Zingiberaceae extracts and flavones isolated from Kaempferia parviflora

Sookkongwaree, K; Geitmann, Matthis; Roengsumran, S; Petsom, A et al.

Part of Pharmazie, p. 717-721, 2006.

Interaction, Organisation, Tasks and Possibilities for Learning about Mathematical Relationships:: A Swedish Classroom Compared with a US Classroom

Liljestrand, Johan

2006.

Isolation and properties of the CYP2D25 promoter: Transcriptional regulation by vitamin D3 metabolites

Ellfolk, Maria; Norlin, Maria; Wikvall, Kjell

Part of Biochemical and Biophysical Research Communications - BBRC, p. 568-572, 2006.

DOI for Isolation and properties of the CYP2D25 promoter: Transcriptional regulation by vitamin D3 metabolites

Non-identical electronic characters of the internucleotidic phosphates in RNA modulate the chemical reactivity of the phosphodiester bonds.

Barman, Jharna; Acharya, Sandipta; Zhou, Chuanzheng; Chatterjee, Subhrangsu et al.

Part of Org Biomol Chem, p. 928-41, 2006.

Screening and characterization of variant Theta-class glutathione transferases catalyzing the activation of ethylene dibromide to a mutagen

Josephy, P. David; Taylor, Patricia L.; Vervaet, Gaby; Mannervik, Bengt

Part of Environmental and Molecular Mutagenesis, p. 657-665, 2006.

DOI for Screening and characterization of variant Theta-class glutathione transferases catalyzing the activation of ethylene dibromide to a mutagen

Sensitivity analysis and error structure of progress curves

Gutierrez Arenas, Omar; Danielson, U Helena

Part of Analytical Biochemistry, p. 1-10, 2006.

DOI for Sensitivity analysis and error structure of progress curves

Universal method for synthesis of artificial gel antibodies by the imprinting approach combined with a unique electrophoresis technique for detection of minute structural differences of proteins, viruses and cells (bacteria): Ia. Gel antibodies against proteins (transferrins)

Takatsy, Aniko; Kilár, Aniko; Kilár, Ferenc; Hjertén, Stellan

Part of Journal of Separation Science, p. 2802-2809, 2006.

DOI for Universal method for synthesis of artificial gel antibodies by the imprinting approach combined with a unique electrophoresis technique for detection of minute structural differences of proteins, viruses and cells (bacteria): Ia. Gel antibodies against proteins (transferrins)

Universal method for synthesis of artificial gel antibodies by the imprinting approach combined with a unique electrophoresis technique for detection of minute structural differences of proteins, viruses, and cells (bacteria): II. Gel antibodies against virus (Semliki Forest Virus)

Takatsy, Aniko; Sedzik, Jan; Kilar, Ferenc; Hjertén, Stellan

Part of Journal of Separation Science, p. 2810-2815, 2006.

DOI for Universal method for synthesis of artificial gel antibodies by the imprinting approach combined with a unique electrophoresis technique for detection of minute structural differences of proteins, viruses, and cells (bacteria): II. Gel antibodies against virus (Semliki Forest Virus)

Universal method for synthesis of artificial gel antibodies by the imprinting approach combined with a unique electrophoresis technique for detection of minute structural differences of proteins, viruses, and cells (bacteria). III: Gel antibodies against cells (bacteria)

Bacskay, Ivett; Takatsy, Aniko; Vegvari, Akos; Elfwing, Anders et al.

Part of Electrophoresis, p. 4682-4687, 2006.

DOI for Universal method for synthesis of artificial gel antibodies by the imprinting approach combined with a unique electrophoresis technique for detection of minute structural differences of proteins, viruses, and cells (bacteria). III: Gel antibodies against cells (bacteria)

Activation of anticancer prodrugs by human glutathione transferases

Eklund, Birgitta; Elfarra, Adnan A.; Mannervik, Bengt

Part of FEBS Journal, p. 546 Suppl-, 2005.

Catalysis of potato epoxide hydrolase, StEH1

Elfström, Lisa; Widersten, Mikael

Part of Biochemical Journal, p. 633-640, 2005.

DOI for Catalysis of potato epoxide hydrolase, StEH1

Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts.

Akoachere, Monique; Iozef, Rimma; Rahlfs, Stefan; Deponte, Marcel et al.

Part of Biol Chem, p. 41-52, 2005.

Development and initial evaluation of PEG-stabilized disks as novel model membranes

Johansson, Emma; Engvall, Caroline; Arfvidsson, Maria; Lundahl, Per et al.

Part of Biophysical Chemistry, p. 183-192, 2005.

DOI for Development and initial evaluation of PEG-stabilized disks as novel model membranes

Diverging substrate specificites from a glutathione transferase library analyzed by multivariate methods

Kurtovic, Sanela; Runarsdottir, Arna; Larsson, Anna-Karin; Emrén, Lars O et al.

Part of FEBS Journal, p. 90 Suppl-, 2005.

Exploring protein evolution by saturation mutagenesis of the GST M2-2 active site residue 210

Andersson, Malena; Mannervik, Bengt

Part of FEBS Journal, p. 81 Suppl-, 2005.

Exploring the importance of an active site residue on the stereo and regio selectivity of Mu class glutathione transferases

Ivarsson, Ylva; Mannervik, Bengt

Part of FEBS Journal, p. 88 Suppl-, 2005.

Human glutathione transferase A3-3 active as steroid double-bond isomerase

Raffalli-Mathieu, Francoise; Mannervik, Bengt

Part of Methods of Enzymology, p. 265-278, 2005.

Identification and characterization of the promoter for the gene encoding human tripeptidyl-peptidase II.

Lindås, Ann-Christin; Tomkinson, Birgitta

Part of Gene, p. 249-57, 2005.

Isolation of novel single-chain Cro proteins targeted for binding to the bcl-2 transcription initiation site by repertoire selection and subunit combinatorics

Jonas, Kristina; Van Der Vries, Erhard; Nilsson, Mikael T.I.; Widersten, Mikael

Part of Protein Engineering Design & Selection, p. 537-546, 2005.

DOI for Isolation of novel single-chain Cro proteins targeted for binding to the bcl-2 transcription initiation site by repertoire selection and subunit combinatorics

Mitotic infidelity and centrosome duplication errors in cells overexpressing tripeptidyl-peptidase II.

Stavropoulou, Vaia; Xie, Jianjun; Henriksson, Marie; Tomkinson, Birgitta et al.

Part of Cancer Res, p. 1361-8, 2005.

Nomenclature for mammalian soluble glutathione transferases

Mannervik, Bengt; Board, Philip G; Hayes, John D; Listowsky, Irving et al.

Part of Methods of Enzymology, p. 1-8, 2005.

Novel C-terminal functionalities in hepatitis C virus NS3 protease inhibitors

Rönn, Robert; Gossas, T; Sabnis, Y A; Åkerblom, E et al.

2005.

Optimizing the heterologous expression of glutathione transferase

Mannervik, Bengt

Part of Methods of Enzymology, p. 254-265, 2005.

Peptide phage display for probing GST-protein interactions.

Edalat, Maryam H; Mannervik, Bengt

Part of Methods Enzymol, p. 354-67, 2005.

Processive action of cellobiohydrolase Cel7A from Trichoderma reesei is revealed as a

Kipper, Kalle; Väljamäe, Priit; Johansson, Gunnar

Part of Biochemical Journal, p. 1-9, 2005.

Regio- and enantioselectivities in epoxide conjugations are modulated by residue 210 in Mu class glutathione transferases.

Ivarsson, Ylva; Mannervik, Bengt

Part of Protein Eng Des Sel, p. 607-16, 2005.

Residue 234 in glutathione transferase T1-1 plays a pivotal role in the catalytic activity and the selectivity against alternative substrates

Shokeer, Abeer; Larsson, Anna-Karin; Mannervik, Bengt

Part of Abstracts of the 30th FEBS Congress, p. 99 Suppl-, 2005.

DOI for Residue 234 in glutathione transferase T1-1 plays a pivotal role in the catalytic activity and the selectivity against alternative substrates

Residue 234 in glutathione transferase T1-1 plays a pivotal role in the catalytic activity and the selectivity against alternative substrates

Shokeer, Abeer; Larsson, Anna-Karin; Mannervik, Bengt

Part of Biochemical Journal, p. 387-92, 2005.

DOI for Residue 234 in glutathione transferase T1-1 plays a pivotal role in the catalytic activity and the selectivity against alternative substrates

Site-directed substitution of the key residue at the subunit interface of GST P1-1 by S-alkylcysteine residues sustains glutathione binding and catalytic activity of the enzyme

Hegazy, Usama; Mannervik, Bengt

Part of FEBS Journal, p. 87 Suppl-, 2005.

The Saccharomyces cerevisiae ORF YNR064c protein has characteristics of an 'orphaned' epoxide hydrolase

Elfström, Lisa; Widersten, Mikael

Part of Biochimica et Biophysica Acta - Proteins and Proteomics, p. 213-221, 2005.

DOI for The Saccharomyces cerevisiae ORF YNR064c protein has characteristics of an 'orphaned' epoxide hydrolase

Tripeptidyl-peptidase II: a multi-purpose peptidase.

Tomkinson, Birgitta; Lindås, Ann-Christin

Part of Int J Biochem Cell Biol, p. 1933-7, 2005.

A new enzyme by rational design - the incorporation of a single His residue enables efficient thioester hydrolysis by human glutathione transferase A1-1

Hederos, Sofia; Broo, Kerstin; Jakobsson, Emma; Kleywegt, Gerard J et al.

Part of Proc. Nat. Acad. Sci., p. 13163-13167, 2004.

Determination of affinity constants by competitive binding in partial filling capillary electrophoresis

Nilsson, Mikael; Johansson, Gunnar; Isaksson, Roland

Part of Electrophoresis, p. 1022-1027, 2004.

Improved structure-activity relationship analysis of HIV-1 protease inhibitors using interaction kinetic data

Shuman, Cynthia; Vrang, Lotta; Danielson, U. Helena

Part of Journal of Medicinal Chemistry, p. 5953-61, 2004.

DOI for Improved structure-activity relationship analysis of HIV-1 protease inhibitors using interaction kinetic data

Incorporation of a single His residue by rational design enables thiol-ester hydrolysis by human glutathione transferase A1-1.

Hederos, Sofia; Broo, Kerstin S; Jakobsson, Emma; Kleywegt, Gerard J et al.

Part of Proc Natl Acad Sci U S A, p. 13163-7, 2004.

Mutagenesis of the cysteine residues in the transcription factor NtcA from Anabaena PCC 7120 and its effects on DNA binding in vitro.

Wisén, Susanne; Bergman, Birgitta; Mannervik, Bengt

Part of Biochim Biophys Acta, p. 156-63, 2004.

Optimisation of peptide-based inhibitors of full-length hepatitis C virus NS3 protease

Poliakov, Anton; Johansson, A; Åkerblom, E; Lindeberg, G et al.

2004.

Repertoire selection of variant single-chain Cro: towards directed DNA-binding specificity of helix-turn-helix proteins

Nilsson, Mikael T.I.; Widersten, Mikael

Part of Biochemistry, p. 12038-12047, 2004.

DOI for Repertoire selection of variant single-chain Cro: towards directed DNA-binding specificity of helix-turn-helix proteins

Selective expression of detoxifying glutathione transferases in mouse colon: effect of experimental colitis and the presence of bacteria.

Edalat, Maryam; Mannervik, Bengt; Axelsson, Lars-Göran

Part of Histochem Cell Biol, p. 151-9, 2004.

Tripeptidyl-peptidase II

Tomkinson, Birgitta

Part of Handbook of proteolytic enzymes, p. 1882-1885, 2004.

Candida albicans secreted aspartic peptidase specificity: A chromogenic combinatorial approach

Beyer, B; Rubin, J; Johnson, J; Chung, A et al.

Part of Biopolymers, p. 310-P025, 2003.

Cellobiose Quinone Oxidoreductase from the white rot fungus Phanerochaete chrysosporium is produced by intracellular proteolysis of Cellobiose Dehydrogenase.

Raices, Manuel; Montesino, Raquel; Cremata, Jose; Szabó, István et al.

Part of Biochimica et Biophysica Acta: Gene Structure and expression, p. 15-22, 2002.

Metabolism of 4 beta -hydroxycholesterol in humans

Bodin, Karl; Andersson, Ulla; Rystedt, Eva; Ellis, Eva et al.

Part of Journal of Biological Chemistry, p. 31534-31540, 2002.

DOI for Metabolism of 4 beta -hydroxycholesterol in humans

Discrimination between enantioselective and non-selective binding sites on cellobiohydrolase-based stationary phases by selective displacers

Henriksson, Hongbin; Pettersson, Göran; Johansson, Gunnar

Part of Journal of Chromatography A, p. 107-115, 1999.

Probing the kinetic mechanism and coenzyme specificity of glutathione reductase from the cyanobacterium Anabaena PCC 7120 by redesign of the pyridine-nucleotide-binding site

Danielson, U. Helena; Jiang, Fanyi Y; Hansson, Lars O.; Mannervik, Bengt

Part of Biochemistry, p. 9254-9263, 1999.

DOI for Probing the kinetic mechanism and coenzyme specificity of glutathione reductase from the cyanobacterium Anabaena PCC 7120 by redesign of the pyridine-nucleotide-binding site

Tripeptidyl peptidases: enzymes that count.

Tomkinson, Birgitta

Part of Trends Biochem Sci, p. 355-9, 1999.

Fasciculins, cholinesterase inhibitors from mamba venoms

Karlsson, E; Harvey, A L; Cervenansky, C; Kleywegt, G J et al.

Part of Enzymes from snake venom, p. 633-688, 1998.

Progress curves as a means for functional classification of cellulases.

Johansson, Gunnar

Part of Europen Journal of Biochemistry, 1998.

The Initial Kinetics of Hydrolysis by Cellobiohydrolases I and II is Consistent with a Cellulose Surface-Erosion Model

Väljamäe, Priit; Sild, Veljo; Pettersson, Göran; Johansson, Gunnar

Part of European Journal of Biochemistry, p. 469-475, 1998.

Electron transfer between cellobiose dehydrogenase and graphite electrodes

Larsson, Ted; Elmgren, Maja; Lindquist, Sten-Eric; Tessema, Merid et al.

Part of Analytica Chimica Acta, p. 207-215, 1996.

DOI for Electron transfer between cellobiose dehydrogenase and graphite electrodes

Isothiocyanates as substrates for human glutathione transferases: structure-activity studies

Kolm, Rüdiger H.; Danielson, U Helena; Zhang, Y.uesheng; Talalay, Paul et al.

Part of Biochemical Journal, p. 453-459, 1995.

Comparision of substrate specificities of protein kinases A and C based on peptide substrates

Loog, Mart; Eller, Marika; Ekman, Pia; Engström, Lorentz et al.

Part of Bioorganic chemistry, p. 328-336, 1994.

DOI for Comparision of substrate specificities of protein kinases A and C based on peptide substrates

D-amino acid residues as substrate specificity determinants for casein kinase II

Toomik, Reet; Eller, Marika; Ekman, Pia; Ragnarsson, Ulf et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 1564-1569, 1994.

DOI for D-amino acid residues as substrate specificity determinants for casein kinase II

Engineering of a metal coordinating site into human glutathione transferase M1-1 based on immobilized metal ion affinity chromatography of homologous rat enzymes

Chaga, Grigoriy; Widersten, Mikael; Andersson, Lennart; Porath, Jerker et al.

Part of Protein Engineering, p. 1115-1119, 1994.

DOI for Engineering of a metal coordinating site into human glutathione transferase M1-1 based on immobilized metal ion affinity chromatography of homologous rat enzymes

Protein kinase assay using tritiated peptide substrates and ferric adsorbent paper for phosphopeptide binding

Toomik, Reet; Ekman, Pia; Eller, Marika; Järv, Jaak et al.

Part of Analytical Biochemistry, p. 348-353, 1993.

DOI for Protein kinase assay using tritiated peptide substrates and ferric adsorbent paper for phosphopeptide binding

Substrate specificity of protein kinase C studied with peptides containing D-amino acid residues.

Eller, Marika; Järv, Jaak; Toomik, Reet; Ragnarsson, Ulf et al.

Part of Journal of Biochemistry, p. 177-180, 1993.

The active site in class alpha glutathione transferases

Sinning, I; Kleywegt, G J; Mannervik, B; Board, P G et al.

Part of Structure and Function of Glutathione Transferases, p. 75-85, 1993.

Model studies on iron (III) ion affinity chromatography: II. Interaction of immobilized ferric ions with phosphorylated amino acids, peptides and proteins

Muszynska, Grazyna; Dobrowolska, Grazyna; Medin, Anders; Ekman, Pia et al.

Part of Journal of Chromatography A, p. 19-28, 1992.

DOI for Model studies on iron (III) ion affinity chromatography: II. Interaction of immobilized ferric ions with phosphorylated amino acids, peptides and proteins

Peptide fragments of myelin basic protein as substrates of protein kinase C.

Eller, Marika; Järv, Jaak; Toomik, Reet; Ragnarsson, Ulf et al.

Part of Biochemistry International, p. 625-631, 1992.

Two methods to avoid the effect of endogenous inhibitors during the assay of protein kinase C activity in tissue extracts.

Ekman, Pia; Eller, Marika; Ragnarsson, Ulf; Engström, Lorentz

Part of Preparative Biochemistry, p. 165-175, 1992.

DOI for Two methods to avoid the effect of endogenous inhibitors during the assay of protein kinase C activity in tissue extracts.

Studies on the substrate specificity of cAMP-dependent protein kinase using diastereomeric peptides

Eller, Marika; Sepp, A; Toomik, Reet; Ekman, Pia et al.

Part of Biochemistry International, p. 453-460, 1991.

Cooperative effect of fructose bisphosphate and glyceraldehyde-3-phosphate dehydrogenase on aldolase action

Neuzil, Jiri; Danielson, Helena; Welch, G Rickey; Ovádi, Judit

Part of Biochimica et Biophysica Acta, p. 307-312, 1990.

DOI for Cooperative effect of fructose bisphosphate and glyceraldehyde-3-phosphate dehydrogenase on aldolase action

Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases

Wallin, Margareta; Deinum, Johanna; Goobar, Laura; Danielson, U Helena

Part of Journal of General Virology, p. 1985-1991, 1990.

DOI for Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases

Reaction of pyridine derivatives with butyl glycidyl ether as a model system for glycidyl ether modified agarose: structural assignment by selective inept spectra

Gogoll, Adolf; Oscarsson, Sven

Part of Tetrahedron, p. 2539-2548, 1990.

DOI for Reaction of pyridine derivatives with butyl glycidyl ether as a model system for glycidyl ether modified agarose: structural assignment by selective inept spectra

Glutathione transferases - structure and catalytic activity

Mannervik, Bengt; Danielson, U Helena

Part of Crc Critical Reviews in Biochemistry, p. 283-337, 1988.

Paradoxical inhibition of rat glutathione transferase 4-4 by indomethacin explained by substrate-inhibitor-enzyme complexes in a random-order sequential mechanism

Danielson, U Helena; Mannervik, Bengt

Part of Biochemical Journal, p. 705-711, 1988.

Relaxed thiol substrate specificity of glutathione transferase effected by a non-substrate glutathione derivative

Principato, Giovanni B; Danielson, U Helena; Mannervik, Bengt

Part of FEBS Letters, p. 155-158, 1988.

DOI for Relaxed thiol substrate specificity of glutathione transferase effected by a non-substrate glutathione derivative

Expression of class-pi glutathione transferase in drug-resistant human-melanoma cells

Mannervik, Bengt; Castro, Victor M; Danielson, U Helena; Platz, A et al.

Part of Proceedings of the American Association of Cancer Research, p. 5-5, 1987.

Structure-activity relationships of 4-hydroxyalkenals in the conjugation catalysed by mammalian glutathione transferases

Danielson, U Helena; Esterbauer, Hermann; Mannervik, Bengt

Part of Biochemical Journal, p. 707-713, 1987.

Kinetic independence of the subunits of cytosolic glutathione transferase from the rat

Danielson, U Helena; Mannervik, Bengt

Part of Biochemical Journal, p. 263-267, 1985.

Purification of major basic glutathione transferase isoenzymes from rat liver by use of affinity chromatography and fast protein liquid chromatofocusing

Ålin, Per; Jensson, Helgi; Guthenberg, Claes; Danielson, U Helena et al.

Part of Analytical Biochemistry, p. 313-320, 1985.

DOI for Purification of major basic glutathione transferase isoenzymes from rat liver by use of affinity chromatography and fast protein liquid chromatofocusing

STRUCTURAL DATA AND ENZYMATIC-PROPERTIES DEFINING 3 CLASSES OF MAMMALIAN CYTOSOLIC GLUTATHIONE TRANSFERASE

Mannervik, Bengt; Ålin, P; Danielson, U Helena; Guthenberg, C et al.

Part of Federation proceedings, p. 471-471, 1985.

Amino acid sequence at the phosphorylated site of rat liver fructose-1,6-diphosphatase and phosphorylation of a corresponding synthetic peptide

Humble, Elisabet; Dahlqvist-Edberg, Ulla; Ek, Pia; Netzel, Elvy et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 1064-1072, 1979.

DOI for Amino acid sequence at the phosphorylated site of rat liver fructose-1,6-diphosphatase and phosphorylation of a corresponding synthetic peptide

New Scaffolds for Design of Inhibitors of Drug Resistant HIV-1 Protease Identified by Fragment Library Screening

Winquist, Johan; Nordström, Helena; Geitmann, Matthis; Gossas, Thomas et al.

Simulated collision induced unfolding of norovirus capsid dimers reveal strain-specific stability profiles

Brodmerkel, Maxim N.; De Santis, Emiliano; Uetrecht, Charlotte; Caleman, Carl et al.

Part of Physical Chemistry, Chemical Physics - PCCP

Stereoselectivity in Catalyzed Transformation of a 1,2-Disubstituted Vicinal Diol and the Corresponding Diketone by Wild Type and Laboratory Evolved Alcohol Dehydrogenases

Maurer, Dirk; Enugala, Thilak Reddy; Hamnevik, Emil; Bauer, Paul et al.