BIOCHEMISTRY

Biochemistry has a long history at Uppsala University, with roots in the research established by the chemists The Svedberg and Arne Tiselius, both Nobel Laureates and among the internationally most prominent scientists from Sweden.

Our research areas

Our research within Biochemistry

Today, the world class research in biochemistry carried out at the Department of Chemistry – BMC is focused on issues related to the design and synthesis of biological macromolecules, analysis of the structure and dynamics of proteins and complex molecular systems, how biological function emerges and is regulated by molecular interactions. Fundamental studies of enzyme catalysis and metabolic pathways is complemented by applied research based on protein engineering and innovative strategies for drug discovery. The research is based on state-of-the-art experimental and theoretical approaches, ranging from physical-chemical approaches to 3D structural modelling and bioinformatics.

The research program in biochemistry is strong in method and technology development. Biochemical methods serve as the foundation for production of biomolecules and advanced studies of biological systems and their regulation, relevant for the understanding of how diseases can be diagnosed and treated. Protein engineering and peptide display methods, for example, provide novel tools for exploring the relationship between protein structure and function, as well as for developing and optimizing synthetic molecules with new function. Collaborations with synthetic organic chemists in the department provides the possibility to also obtain specifically designed small organic molecules and synthetic peptides, and structural studies by NMR. Sensitive, time resolved, high-resolution biophysical methods provide details of the structure and dynamics of biological systems, relevant also for many applications.

The biochemistry program in the department hosts the Biophysical Screening and Characterization facility, belonging to the Drug Discovery and Development platform of SciLifeLab, part of a national infrastructure for research in life science. The researchers involved thereby belong to the creative and research-intense SciLifeLab community, and have good access to a broad knowledge-base as well as cutting-edge expertise in the Life sciences.