Publikationer inom biokemi

Aronsson, Hanna

Biophysical Analysis of Novel Viral-Host Protein-Protein Interactions Identified by Proteomic Peptide Phage Display

2020.

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Abramsson, Mia

Biophysical Characterization of Hit Compounds against a Structurally Dynamic Protein for Drug Discovery

2020.

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Kulkarni, Yashraj

Computational Modeling of the Structure, Function and Dynamics of Biomolecular Systems

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Szeler, Klaudia

Computational Protein Evolution: Modeling the Selectivity and Promiscuity of Engineered Enzymes

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Widersten, Mikael

Engineering aldolases for asymmetric synthesis

Ingår i Methods in Enzymology, 2020.

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Ben-David, Moshe; Soskine, Misha; Dubovetskyi, Artem; Cherukuri, Kesava-Phaneendra et al.

Enzyme Evolution An Epistatic Ratchet versus a Smooth Reversible Transition

Ingår i Molecular biology and evolution, s. 1133-1147, 2020.

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Wilson, Philippe B.; Grootveld, Martin; Kamerlin, Shina C. Lynn

Errors in DFT integration grids and their potential impact on chemical shift calculations

Ingår i Magnetic Resonance in Chemistry, s. 116-117, 2020.

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Xu, Xingxing; Makaraviciute, Asta; Abdurakhmanov, Eldar; Werneling, Fredrik et al.

Estimating Detection Limits of Potentiometric DNA sensors Using Surface Plasmon Resonance Analyses

Ingår i ACS Sensors, s. 217-224, 2020.

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Bhaduri, Anindya; Gardner, Jasmine; Abrams, Cameron F.; Graham-Brady, Lori

Free energy calculation using space filled design and weighted reconstruction: a modified single sweep approach

Ingår i Molecular Simulation, s. 193-206, 2020.

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Simonetti, Leandro; Ivarsson, Ylva

Genetically Encoded Cyclic Peptide Phage Display Libraries

Ingår i ACS CENTRAL SCIENCE, s. 336-338, 2020.

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Yang, Jie; Talibov, Vladimir O; Peintner, Stefan; Rhee, Claire et al.

Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1

Ingår i ACS OMEGA, s. 3979-3995, 2020.

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Gardner, Jasmine M.; Biler, Michal; Risso, Valeria A.; Sanchez-Ruiz, Jose M. et al.

Manipulating Conformational Dynamics To Repurpose Ancient Proteins for Modern Catalytic Functions

Ingår i ACS Catalysis, s. 4863-4870, 2020.

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Szeler, Klaudia; Williams, Nicholas H.; Hengge, Alvan C.; Kamerlin, Shina C. Lynn

Modeling the Alkaline Hydrolysis of Diaryl Sulfate Diesters: A Mechanistic Study

Ingår i Journal of Organic Chemistry, s. 6489-6497, 2020.

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Lüking, Malin

Modelling the Protein-DNA Interface

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Calixto, Ana Rita; Moreira, Catia; Kamerlin, Shina Caroline Lynn

Recent Advances in Understanding Biological GTP Hydrolysis through Molecular Simulation

Ingår i ACS OMEGA, s. 4380-4385, 2020.

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Enugala, Thilak Reddy; Corbella Morató, Marina; Kamerlin, Shina Caroline Lynn; Widersten, Mikael

The Role of Substrate-Coenzyme Crosstalk in Determining Turnover Rates in Rhodococcus ruber Alcohol Dehydrogenase

Ingår i ACS Catalysis, s. 9115-9128, 2020.

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Ueki, Yumi; Kruse, Thomas; Weisser, Melanie Bianca; Sundell, Gustav N. et al.

A Consensus Binding Motif for the PP4 Protein Phosphatase

Ingår i Molecular Cell, s. 953-964.e6, 2019.

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Kaldmae, Margit; Sahin, Cagla; Saluri, Mihkel; Marklund, Erik et al.

A strategy for the identification of protein architectures directly from ion mobility mass spectrometry data reveals stabilizing subunit interactions in light harvesting complexes

Ingår i Protein Science, s. 1024-1030, 2019.

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Ivarsson, Ylva; Jemth, Per

Affinity and specificity of motif-based protein-protein interactions

Ingår i Current opinion in structural biology, s. 26-33, 2019.

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Burke, Jason R.; La Clair, James J.; Philippe, Ryan N.; Pabis, Anna et al.

Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases

Ingår i ACS Catalysis, s. 8388-8396, 2019.

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Billinger, Erika; Zuo, Shusheng; Johansson, Gunnar

Characterization of Serine Protease Inhibitor from Solanum tuberosum Conjugated to Soluble Dextran and Particle Carriers

Ingår i ACS Omega, s. 18456 18456-18464 18464, 2019.

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Al-Smadi, Derar; Enugala, Thilak Reddy; Kessler, Vadim; Mhasal, Anil Rhanu et al.

Chemical and Biochemical Approaches for the Synthesis of Substituted Dihydroxybutanones and Di-, and Tri-Hydroxypentanones

Ingår i Journal of Organic Chemistry, s. 6982-6991, 2019.

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Drevinskas, Tomas; Maruska, Audrius; Telksnys, Laimutis; Hjertén, Stellan et al.

Chromatographic Data Segmentation Method: A Hybrid Analytical Approach for the Investigation of Antiviral Substances in Medicinal Plant Extracts

Ingår i Analytical Chemistry, s. 1080-1088, 2019.

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Kulkarni, Yashraj; Kamerlin, Shina C. Lynn

Computational physical organic chemistry using the empirical valence bond approach

Ingår i Advances in Physical Organic Chemistry, s. 69-104, 2019.

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Calixto, Ana Rita; Ramos, Maria Joao; Fernandes, Pedro Alexandrino

Conformational diversity induces nanosecond-timescale chemical disorder in the HIV-1 protease reaction pathway

Ingår i Chemical Science, s. 7212-7221, 2019.

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Ivarsson, Ylva; Jemth, Per

Editorial overview: Folding and binding

Ingår i Current opinion in structural biology, s. 139-140, 2019.

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Gardner, Jasmine M.; Abrams, Cameron F.

Energetics of Flap Opening in HIV-1 Protease: String Method Calculations

Ingår i Journal of Physical Chemistry B, s. 9584-9591, 2019.

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Kaldmäe, Margit; Österlund, Nicklas; Lianoudaki, Danai; Sahin, Cagla et al.

Gas-Phase Collisions with Trimethylamine-N-Oxide Enable Activation-Controlled Protein Ion Charge Reduction

Ingår i Journal of the American Society for Mass Spectrometry, s. 1385-1388, 2019.

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van Kuilenburg, Andre B. P.; Tarailo-Graovac, Maja; Richmond, Phillip A.; Drogemoller, Britt I. et al.

Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS

Ingår i New England Journal of Medicine, s. 1433-1441, 2019.

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Calixto, Ana R.; Moreira, Catia; Pabis, Anna; Kötting, Carsten et al.

GTP Hydrolysis Without an Active Site Base: A Unifying Mechanism for Ras and Related GTPases

Ingår i Journal of the American Chemical Society, s. 10684-10701, 2019.

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Yang, Gloria; Anderson, Dave W.; Baier, Florian; Dohmen, Elias et al.

Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme

Ingår i Nature Chemical Biology, s. 1120-1128, 2019.

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Billinger, Erika; Zuo, Shusheng; Lundmark, Kristoffer; Johansson, Gunnar

Light scattering determination of the stoichiometry for protease-potato serine protease inhibitor complexes

Ingår i Analytical Biochemistry, 2019.

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Liao, Qinghua; Lüking, Malin; Krueger, Dennis M.; Deindl, Sebastian et al.

Long Time-Scale Atomistic Simulations of the Structure and Dynamics of Transcription Factor-DNA Recognition

Ingår i Journal of Physical Chemistry B, s. 3576-3590, 2019.

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Urbanaviciute, Indre; Meng, Xiao; Biler, Michal; Wei, Yingfen et al.

Negative piezoelectric effect in an organic supramolecular ferroelectric

Ingår i Materials Horizons, s. 1688-1698, 2019.

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Spetsare, Ebba

Optimization of a pharmacokinetic assay in a bridging assay format using the Gyrolab immunoassay platform

2019.

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Lúðvíksdóttir, Hildur

Production and characterization of LSD1 and LSD2 for fragment based drug discovery

2019.

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Tatum, Natalie J.; Duarte, Fernanda; Kamerlin, Shina C. Lynn; Pohl, Ehmke

Relative Binding Energies Predict Crystallographic Binding Modes of Ethionamide Booster Lead Compounds

Ingår i Journal of Physical Chemistry Letters, s. 2244-2249, 2019.

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Corbella, Marina; Cupellini, Lorenzo; Lipparini, Filippo; Scholes, Gregory D. et al.

Spectral Variability in Phycocyanin Cryptophyte Antenna Complexes is Controlled by Changes in the alpha-Polypeptide Chains

Ingår i CHEMPHOTOCHEM, s. 945 945-956 956, 2019.

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Ge, Changrong; Xu, Bingze; Liang, Bibo; Lönnblom, Erik et al.

Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies

Ingår i Arthritis & Rheumatology, s. 210-221, 2019.

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Xu, Xingxing; Makaraviciute, Asta; Kumar, Shalen; Wen, Chenyu et al.

Structural Changes of Mercaptohexanol Self-assembled Monolayers on Gold and their Influence on Impedimetric Aptamer Sensors

Ingår i Analytical Chemistry, s. 14697-14704, 2019.

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Parkash, Vimal; Kulkarni, Yashraj; ter Beek, Josy; Shcherbakova, Polina V. et al.

Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon

Ingår i Nature Communications, 2019.

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Jespersen, Nathan; Estelle, Aidan; Waugh, Nathan; Davey, Norman E. et al.

Systematic identification of recognition motifs for the hub protein LC8

Ingår i LIFE SCIENCE ALLIANCE, 2019.

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Moreira, Catia; Calixto, Ana R.; Richard, John P.; Kamerlin, Shina Caroline Lynn

The role of ligand-gated conformational changes in enzyme catalysis

Ingår i Biochemical Society Transactions, s. 1449-1460, 2019.

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Kulkarni, Yashraj; Amyes, Tina L.; Richard, John P.; Kamerlin, Shina C. Lynn

Uncovering the Role of Key Active-Site Side Chains in Catalysis: An Extended Brønsted Relationship for Substrate Deprotonation Catalyzed by Wild-Type and Variants of Triosephosphate Isomerase

Ingår i Journal of the American Chemical Society, s. 16139-16150, 2019.

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Fabini, Edoardo; Talibov, Vladimir O; Mihalic, Filip; Naldi, Marina et al.

Unveiling the Biochemistry of the Epigenetic Regulator SMYD3

Ingår i Biochemistry, s. 3634-3645, 2019.

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Marklund, Erik; Benesch, Justin L. P.

Weighing-up protein dynamics: the combination of native mass spectrometry and molecular dynamics simulations

Ingår i Current opinion in structural biology, s. 50-58, 2019.

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Kjellander, Marcus; Billinger, Erika; Ramachandraiah, Harisha; Boman, Mats et al.

A flow-through nanoporous alumina trypsin bioreactor for mass spectrometry peptide fingerprinting

Ingår i Journal of Proteomics, s. 165-172, 2018.

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Salamanova, Evdokiya; Costeira-Paulo, Joana; Han, Kyou-Hoon; Kim, Do-Hyoung et al.

A subset of functional adaptation mutations alter propensity for alpha-helical conformation in the intrinsically disordered glucocorticoid receptor taulcore activation domain

Ingår i Biochimica et Biophysica Acta - General Subjects, s. 1452-1461, 2018.

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Kulesza, Alexander; Marklund, Erik; MacAleese, Luke; Chirot, Fabien et al.

Bringing Molecular Dynamics and Ion-Mobility Spectrometry Closer Together: Shape Correlations, Structure-Based Predictors, and Dissociation

Ingår i Journal of Physical Chemistry B, s. 8317-8329, 2018.

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Purg, Miha

Computational Modeling of the Mechanisms and Selectivity of Organophosphate Hydrolases

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Maurer, Dirk; Lohkamp, Bernhard; Krumpel, Michael; Widersten, Mikael et al.

Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism

Ingår i Biochemical Journal, s. 2395-2416, 2018.

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Holbrook, J. Britt; Curry, Stephen; Kamerlin, Shina C. L.

Debate on academic freedom and open access is healthy

Ingår i Nature, s. 494-494, 2018.

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Hamnevik, Emil; Maurer, Dirk; Enugala, Thilak Reddy; Chu, Thao et al.

Directed Evolution of Alcohol Dehydrogenase for Improved Stereoselective Redox Transformations of 1-Phenylethane-1,2-Diol and Its Corresponding Acyloin

Ingår i Biochemistry, s. 1059-1062, 2018.

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Lu, Yi

Effect of transfection reagents on plasmid promoters

2018.

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Petrovic, Dusan; Kamerlin, Shina C. Lynn

Effects of conformational dynamics on enzyme evolution in TIM-barrel-fold proteins

Ingår i Abstracts of Papers of the American Chemical Society, 2018.

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Purg, Miha; Kamerlin, Shina C. Lynn

Empirical Valence Bond Simulations of Organophosphate Hydrolysis: Theory and Practice

Ingår i PHOSPHATASES, s. 3-51, 2018.

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Uduwela, Dimanthi R.; Pabis, Anna; Stevenson, Bradley J.; Kamerlin, Shina C. Lynn et al.

Enhancing the Steroid Sulfatase Activity of the Arylsulfatase from Pseudomonas aeruginosa

Ingår i ACS Catalysis, s. 8902-8914, 2018.

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Janfalk Carlsson, Åsa; Bauer, Paul; Dobritzsch, Doreen; Kamerlin, Shina C Lynn et al.

Epoxide Hydrolysis as a Model System for Understanding Flux Through a Branched Reaction Scheme

Ingår i IUCrJ, s. 269-282, 2018.

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Miton, Charlotte M.; Jonas, Stefanie; Fischer, Gerhard; Duarte, Fernanda et al.

Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. E7293-E7302, 2018.

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Gabelica, Valérie; Marklund, Erik

Fundamentals of ion mobility spectrometry

Ingår i Current opinion in chemical biology, s. 51-59, 2018.

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van Kuilenburg, André; Tarailo-Graovac, Maja; Meijer, Judith; Drogemoller, Britt et al.

Genome sequencing reveals a novel genetic mechanism underlying dihydropyrimidine dehydrogenase deficiency: A novel missense variant c.1700G > A and a large intragenic inversion in DPYD spanning intron 8 to intron 12

Ingår i Human Mutation, s. 947-953, 2018.

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Ali, Muhammad; Ivarsson, Ylva

High-throughput discovery of functional disordered regions

Ingår i Molecular Systems Biology, 2018.

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Amrein, Beat Anton; Runthala, Ashish; Kamerlin, Shina C. Lynn

In Silico-Directed Evolution Using CADEE

Ingår i Computational Methods in Protein Evolution, s. 381-415, 2018.

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Billinger, Erika; Johansson, Gunnar

Kinetic studies of serine protease inhibitors in simple and rapid 'active barrier' model systems: Diffusion through an inhibitor barrier

Ingår i Analytical Biochemistry, s. 43-49, 2018.

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Petrovic, Dusan; Kamerlin, Shina C. Lynn

Legend of a perfect enzyme: Active site architecture and loop dynamics in triosephosphate isomerase

Ingår i Abstracts of Papers of the American Chemical Society, 2018.

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Costeira-Paulo, Joana; Gault, Joseph; Popova, Gergana; Ladds, Marcus J G W et al.

Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase

Ingår i Cell Chemical Biology, s. 309-317, 2018.

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Liao, Qinghua; Kulkarni, Yashraj; Sengupta, Ushnish; Petrovic, Dusan et al.

Loop Motion in Triosephosphate Isomerase Is Not a Simple Open and Shut Case

Ingår i Journal of the American Chemical Society, s. 15889-15903, 2018.

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Gault, Joseph; Lianoudaki, Danai; Kaldmäe, Margit; Kronqvist, Nina et al.

Mass Spectrometry Reveals the Direct Action of a Chemical Chaperone

Ingår i Journal of Physical Chemistry Letters, s. 4082-4086, 2018.

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Petrovic, Dusan; Kamerlin, Shina C. Lynn

Molecular modeling of conformational dynamics and its role in enzyme evolution

Ingår i Current opinion in structural biology, s. 50-57, 2018.

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Ma, Huan; Engel, Sarah; Enugala, Thilak Reddy; Al-Smadi, Derar et al.

New Stereoselective Biocatalysts for Carboligation and Retro-Aldol Cleavage Reactions Derived from D-Fructose 6-Phosphate Aldolase

Ingår i Biochemistry, s. 5877-5885, 2018.

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Pandya, Nikhil J; Seeger, Christian; Babai, Norbert; Gonzalez-Lozano, Miguel A et al.

Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors

Ingår i Cell reports, s. 1218-1230, 2018.

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Belfrage, Anna Karin; Abdurakhmanov, Eldar; Åkerblom, Eva; Brandt, Peter et al.

Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold

Ingår i European Journal of Medicinal Chemistry, s. 453-464, 2018.

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Sundell, Gustav; Arnold, Roland; Ali, Muhammad; Naksukpaiboon, Piangfan et al.

Proteome‐wide analysis of phospho‐regulated PDZ domain interactions

Ingår i Molecular Systems Biology, 2018.

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Young, Gavin; Hundt, Nikolas; Cole, Daniel; Fineberg, Adam et al.

Quantitative mass imaging of single biological macromolecules

Ingår i Science, s. 423-427, 2018.

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Maurer, Dirk; Enugala, Thilak Reddy; Hamnevik, Emil; Bauer, Paul et al.

Stereo- and Regioselectivity in Catalyzed Transformation of a 1,2-Disubstituted Vicinal Diol and the Corresponding Diketone by Wild Type and Laboratory Evolved Alcohol Dehydrogenases

Ingår i ACS Catalysis, s. 7526-7538, 2018.

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Marklund, Erik G.; Zhang, Yichen; Basha, Eman; Benesch, Justin L P et al.

Structural and functional aspects of the interaction partners of the small heat-shock protein in Synechocystis

Ingår i Cell stress & chaperones (Print), s. 723-732, 2018.

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Hampel, Sabrina; Steitz, Jan-Patrick; Baierl, Anna; Lehwald, Patrizia et al.

Structural and Mutagenesis Studies of the Thiamine-Dependent, Ketone-Accepting YerE from Pseudomonas protegens

Ingår i ChemBioChem (Print), s. 2283-2292, 2018.

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Hochberg, Georg K A; Shepherd, Dale A; Marklund, Erik G.; Santhanagoplan, Indu et al.

Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions.

Ingår i Science, s. 930-935, 2018.

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Maurer, Dirk

Structure Function Relationships in Pyrimidine Degrading and Biocatalytic Enzymes, and Their Implications for Cancer Therapy and Green Chemistry

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Al-Smadi, Derar; Enugala, Thilak Reddy; Norberg, Thomas; Kihlberg, Jan et al.

Synthesis of substrates for aldolase-catalyzed reactions: A comparison of methods for the synthesis of substituted phenylacetaldehydes

Ingår i Synlett, s. 1187-1190, 2018.

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Hong, Nan-Sook; Petrovic, Dusan; Lee, Richmond; Gryn'ova, Ganna et al.

The evolution of multiple active site configurations in a designed enzyme

Ingår i Nature Communications, 2018.

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Sundell, Gustav; Vögeli, Beat; Ivarsson, Ylva; Chi, Celestine N.

The Sign of Nuclear Magnetic Resonance Chemical Shift Difference as a Determinant of the Origin of Binding Selectivity: Elucidation of the Position Dependence of Phosphorylation in Ligands Binding to Scribble PDZ1

Ingår i Biochemistry, s. 66-71, 2018.

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Lion, Shamiran

To discover and validate host response biomarkers for Mycobacterium tuberculosis testing on the GeneXpert platform

2018.

Till DiVA

Sundell, Gustav

Using peptide-phage display to capture conditional motif-based interactions

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Wigington, C. P.; Roy, J.; Damle, N. P.; Ulengin-Talkish, I. et al.

A novel role for the Calcineurin phosphatase at the nuclear pore

Ingår i Molecular Biology of the Cell, s. 3727-3727, 2017.

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Ge, Changrong P; Tong, Dongmei R; Liang, Bibo T; Lönnblom, Erik S et al.

Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage

Ingår i JCI INSIGHT, 2017.

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Abdurakhmanov, Eldar; Solbak, Sara Oie; Danielson, U. Helena

Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase

Ingår i Viruses, 2017.

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Zhan, Shaoqi; Martensson, Daniel; Purg, Miha; Kamerlin, Shina C. Lynn et al.

Capturing the Role of Explicit Solvent in the Dimerization of Ru-V(bda) Water Oxidation Catalysts

Ingår i Angewandte Chemie International Edition, s. 6962-6965, 2017.

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Hamnevik, Emil

Characterization and Directed Evolution of an Alcohol Dehydrogenase: A Study Towards Understanding of Three Central Aspects of Substrate Selectivity

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Solbak, Sara M.Ø.; Abdurakhmanov, Eldar; Vedeler, Anni; Danielson, U. Helena

Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition

Ingår i Virology Journal, 2017.

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Bauer, Paul

Computational modelling of enzyme selectivity

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Maximoff, Sergey; Eloge, Josh; Kamerlin, Shina C. Lynn; Florian, Jan

Computational study of relative thermodynamic stability of mutant base pairs between keto, enol and deprotonated forms of guanine and thymine at DNA polymerase lambda active site

Ingår i Abstracts of Papers of the American Chemical Society, 2017.

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Marklund, Erik; Ekeberg, Tomas; Moog, Mathieu; Benesch, Justin L. P. et al.

Controlling Protein Orientation in Vacuum Using Electric Fields

Ingår i Journal of Physical Chemistry Letters, s. 4540-4544, 2017.

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Saupe, Falk; Reichel, Matthias; Huijbers, Elisabeth J. M.; Femel, Julia et al.

Development of a novel therapeutic vaccine carrier that sustains high antibody titers against several targets simultaneously

Ingår i The FASEB Journal, s. 1204-1214, 2017.

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Nakajima, Yoko; Meijer, Judith; Dobritzsch, Doreen; Ito, Tetsuya et al.

Dihydropyrimidinase deficiency in four East Asian patients due to novel and rare DPYS mutations affecting protein structural integrity and catalytic activity

Ingår i Molecular Genetics and Metabolism, s. 216-222, 2017.

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Davey, Norman E.; Seo, Moon-Hyeong; Yadav, Vikash Kumar; Jeon, Jouhyun et al.

Discovery of short linear motif-mediated interactions through phage display of intrinsically disordered regions of the human proteome

Ingår i The FEBS Journal, s. 485-498, 2017.

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Landreh, Michael; Costeira-Paulo, Joana; Gault, Joseph; Marklund, Erik et al.

Effects of Detergent Micelles on Lipid Binding to Proteins in Electrospray Ionization Mass Spectrometry

Ingår i Analytical Chemistry, s. 7425-7430, 2017.

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Wang, Huan; Huang, Xiao; Strømme, Maria; Sjödin, Martin

Electrochemical performance of Terephthalate-Functionalized Poly(3,4-ethylenedioxythiophene) conducting redox polymer

2017.

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Hultqvist, Greta; Åberg, Emma; Camilloni, Carlo; Sundell, Gustav et al.

Emergence and evolution of an interaction between intrinsically disordered proteins

Ingår i eLIFE, 2017.

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Hillier, Heidi Therese

How is substrate selectivity in hydride transfer decided in an alcohol dehydrogenase?: Directed evolution of alcohol dehydrogenase A from Rhodococcus ruber DSM 44541 through iterative saturation mutagenesis, a study to understand the structure and function relationship of enzymatic catalysis

2017.

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Nosrati, Masoumeh; Solbak, Sara; Nordesjö, Olle; Nissbeck, Mikael et al.

Insights from engineering the Affibody-Fc interaction with a computational-experimental method

Ingår i Protein Engineering Design & Selection, s. 593-601, 2017.

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Landreh, Michael; Marklund, Erik G; Uzdavinys, Povilas; Degiacomi, Matteo T. et al.

Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters

Ingår i Nature Communications, 2017.

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Linkuviene, V.; Talibov, Vladimir O.; Danielson, U. Helena; Matulis, D.

Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction

Ingår i European Biophysics Journal, s. S91-S91, 2017.

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Linkuviene, V.; Talibov, Vladimir O; Danielson, U. Helena; Matulis, D.

Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction

Ingår i European Biophysics Journal, s. S311-S311, 2017.

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Cho, S. Ei; Roy, J.; Ivarsson, Ylva; Cyert, M. S.

Investigating the phospho-regulation of ER shaping protein RTN1A (Reticulon-1A) by the Calcineurin phosphatase.

Ingår i Molecular Biology of the Cell, s. 3727-3727, 2017.

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Roy, J.; Wigington, C. P.; Damle, N. P.; Ulengin-Talkish, I. et al.

Mapping the human calcineurin phosphatase signaling network through global identification of short linear motifs that mediate substrate recognition

Ingår i Molecular Biology of the Cell, s. 3727-3727, 2017.

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Landreh, Michael; Andersson, Marlene; Marklund, Erik G.; Jia, Qiupin et al.

Mass spectrometry captures structural intermediates in protein fiber self-assembly

Ingår i Chemical Communications, s. 3319-3322, 2017.

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Porrmann, Joseph; Betcheva-Krajcir, Elitza; Di Donato, Nataliya; Kahlert, Anne-Karin et al.

Novel PRPS1 gain-of-function mutation in a patient with congenital hyperuricemia and facial anomalies

Ingår i American Journal of Medical Genetics. Part A, s. 2736-2742, 2017.

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Wu, Cheng-Guo; Chen, Hui; Guo, Feng; Yadav, Vikash K et al.

PP2A-B' holoenzyme substrate recognition, regulation and role in cytokinesis

Ingår i Cell Discovery, 2017.

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Hamnevik, Emil; Enugala, Thilak Reddy; Maurer, Dirk; Ntuku, Siphosethu et al.

Relaxation of Nonproductive Binding and Increased Rate of Coenzyme Release in an Alcohol Dehydrogenase Increases Turnover With a Non-Preferred Alcohol Enantiomer

Ingår i The FEBS Journal, s. 3895-3914, 2017.

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van Kuilenburg, André B P; Meijer, Judith; Maurer, Dirk; Dobritzsch, Doreen et al.

Severe fluoropyrimidine toxicity due to novel and rare DPYD missense mutations, deletion and genomic amplification affecting DPD activity and mRNA splicing

Ingår i Biochimica et Biophysica Acta, s. 721-730, 2017.

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Wigington, Callie P.; Roy, Jagoree; Damle, Nikhil P.; El Cho, Shein et al.

Uncovering Novel Substrates and Functions for the Calcineurin Phosphatase in Human Cells

Ingår i The FASEB Journal, 2017.

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Erik, Gioeli

Utbytesoptimering inom läkemedelsproduktion: Identifiering av kassationsorsaker inom AstraZenecas packningsprocess i Gärtuna

2017.

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Renaud, Jean-Paul; Chung, Chun-wa; Danielson, U. Helena; Egner, Ursula et al.

Biophysics in drug discovery: impact, challenges and opportunities

Ingår i Nature reviews. Drug discovery, s. 679-698, 2016.

DOI Till DiVA

Bauer, Paul; Janfalk Carlsson, Åsa; Amrein, Beat A.; Dobritzsch, Doreen et al.

Conformational Diversity and Enantioconvergence in Potato Epoxide Hydrolase 1

Ingår i Organic and biomolecular chemistry, s. 5639-5651, 2016.

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Belfrage, Anna Karin; Abdurakhmanov, Eldar; Åkerblom, Eva; Brandt, Peter et al.

Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease

Ingår i Bioorganic & Medicinal Chemistry, s. 2603-2620, 2016.

DOI Till DiVA

Egea-Jimenez, Antonio Luis; Gallardo, Rodrigo; Garcia-Pino, Abel; Ivarsson, Ylva et al.

Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling

Ingår i Nature Communications, 2016.

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Karlsson, O Andreas; Sundell, Gustav N; Andersson, Eva; Ivarsson, Ylva et al.

Improved affinity at the cost of decreased specificity: a recurring theme in PDZ-peptide interactions.

Ingår i Scientific Reports, 2016.

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Talibov, Vladimir O; Linkuvienė, Vaida; Matulis, Daumantas; Danielson, Helena U.

Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII

Ingår i Journal of Medicinal Chemistry, s. 2083-2093, 2016.

DOI Till DiVA

Janfalk Carlsson, Åsa; Bauer, Paul; Dobritzsch, Doreeen; Nilsson, Mikael et al.

Laboratory evolved enzymes provide snapshots of the development of enantioconvergence in enzyme-catalyzed epoxide hydrolysis

Ingår i ChemBioChem (Print), s. 1693-1697, 2016.

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Raykova, Doroteya; Koos, Bjoern; Asplund, Anna; Gelleri, Marton et al.

Let There Be Light!

Ingår i Proteomes, 2016.

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Ma, Huan; Szeler, Klaudia; Kamerlin, Shina Caroline Lynn; Widersten, Mikael

Linking coupled motions and entropic effects to the catalytic activity of 2-deoxyribose-5-phosphate aldolase (DERA)

Ingår i Chemical Science, s. 1415-1421, 2016.

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Nim, Satra; Jeon, Jouhyun; Corbi-Verge, Carles; Seo, Moon-Hyeong et al.

Pooled screening for antiproliferative inhibitors of protein-protein interactions.

Ingår i Nature Chemical Biology, s. 275-281, 2016.

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Garrido-Urbani, Sarah; Garg, Pankaj; Ghossoub, Rania; Arnold, Roland et al.

Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin

Ingår i FEBS Letters, s. 3-12, 2016.

DOI Uppladdad fulltext Till DiVA

Wigington, C. P.; Damle, N. P.; Roy, J.; Cho, S. E. et al.

Uncovering novel substrates and functions for the calcineurin phosphatase in human cells.

Ingår i Molecular Biology of the Cell, 2016.

DOI Till DiVA

Ma, Huan; Enugala, Thilak Reddy; Widersten, Mikael

A micro-plate format assay for real-time screening for new aldolases accepting aryl-substituted acceptor substrates

Ingår i ChemBioChem (Print), s. 2595-2598, 2015.

DOI Till DiVA

Ma, Huan

Aldolases for Enzymatic Carboligation: Directed Evolution and Enzyme Structure-Function Relationship Studies

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Karlsson, O. Andreas; Ramirez, Juan; Öberg, Daniel; Malmqvist, Tony et al.

Design of a PDZbody, a bivalent binder of the E6 protein from human papillomavirus

Ingår i Scientific Reports, 2015.

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Dahlström, Kathe M.; Blikstad, Cecilia; Widersten, Mikael; Salminen, Tiina A.

Directed evolution on FucO - structural explanations for changes in substrate scope

Ingår i Protein Science, s. 199-200, 2015.

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Abdurakhmanov, Eldar

Discovery and evaluation of direct acting antivirals against hepatitis C virus

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Zhang, Wei; Dourado, Daniel F. A. R.; Mannervik, Bengt

Evolution of the active site of human glutathione transferase A2-2 for enhanced activity with dietary isothiocyanates

Ingår i Biochimica et Biophysica Acta - General Subjects, s. 742-749, 2015.

DOI Till DiVA

Amrein, Beat A.; Bauer, Paul; Duarte, Fernanda; Janfalk Carlsson, Åsa et al.

Expanding the catalytic triad in epoxide hydrolases and related enzymes

Ingår i ACS Catalysis, s. 5702-5713, 2015.

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Blikstad, Cecilia; Ivarsson, Ylva

High-throughput methods for identification of protein-protein interactions involving short linear motifs

Ingår i Cell Communication and Signaling, 2015.

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Lindgren, Cecilia; Andersson, Ida E.; Berg, Lotta; Dobritzsch, Doreen et al.

Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes

Ingår i Organic and biomolecular chemistry, s. 6203-6216, 2015.

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Aksoy, N. H.; Mannervik, B.

Inhibitory effects of ethacrynic acid on glutathione S-transferase A1-1 from Callithrix jacchus

Ingår i The FEBS Journal, s. 348-348, 2015.

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Spurny, Radovan; Debaveye, Sarah; Farinha, Ana; Veys, Ken et al.

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the alpha 7 nicotinic acetylcholine receptor

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. E2543-E2552, 2015.

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Danielson, U. Helena

Molecular Interaction Analysis for Discovery of Drugs Targeting Enzymes and for Resolving Biological Function

Ingår i Multifaceted Roles Of Crystallography In Modern Drug Discovery, s. 223-240, 2015.

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Tsourma, Maria

Novel approach to radionuclide therapy of cancer: affibody-based bio-orthogonal chemistry mediated pretargeting

2015.

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Haag, Sabrina; Tuncel, Jonatan; Thordardottir, Soley; Mason, Daniel E. et al.

Positional Identification of RT1-B (HLA-DQ) as Susceptibility Locus for Autoimmune Arthritis

Ingår i Journal of Immunology, s. 2539-2550, 2015.

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Koos, Björn; Cane, Gaëlle; Grannas, Karin; Löf, Liza et al.

Proximity-dependent initiation of hybridization chain reaction

Ingår i Nature Communications, 2015.

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Ganesan, Ashok; Debulpaep, Maja; Wilkinson, Hannah; Van Durme, Joost et al.

Selectivity of Aggregation-Determining Interactions

Ingår i Journal of Molecular Biology, s. 236-247, 2015.

DOI Till DiVA

Ilari, Andrea; Fiorillo, Annarita; Poser, Elena; Lalioti, Vasiliki S. et al.

Structural basis of Sorcin-mediated calcium-dependent signal transduction

Ingår i Scientific Reports, 2015.

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Ilari, Andrea; Fiorillo, Annarita; Poser, Elena; Lalioti, Vasiliki S. et al.

Structural basis of Sorcin-mediated calcium-dependent signal transduction

Ingår i Scientific Reports, 2015.

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Ragnarsson, Ulf; Grehn, Leif; Pehk, Tonis

An unprecedented rearrangement of a 1,1-diprotected hydrazine derivative. Structure revision of a catalyst-containing by-product

Ingår i Tetrahedron Letters, s. 7019-7022, 2014.

DOI Till DiVA

Nakajima, Yoko; Meijer, Judith; Dobritzsch, Doreen; Ito, Tetsuya et al.

Clinical, biochemical and molecular analysis of 13 Japanese patients with beta-ureidopropionase deficiency demonstrates high prevalence of the c.977G > A (p.R326Q) mutation

Ingår i Journal of Inherited Metabolic Disease, s. 801-812, 2014.

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Bauer, Paul

Directed Evolution of ADH-A from Rhodococcus ruber DSM 44541

2014.

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Raposo, Bruno; Dobritzsch, Doreen; Ge, Changrong; Ekman, Diana et al.

Epitope-specific antibody response is controlled by immunoglobuline V_H polymorphisms

Ingår i Journal of Experimental Medicine, s. 405-411, 2014.

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Laadan, B.; Wallace-Salinas, V.; Janfalk Carlsson, Åsa; Almeida, J. et al.

Furaldehyde substrate specificity and kinetics of Saccharomyces cerevisiae alcohol dehydrogenase 1 variants

Ingår i Microbial Cell Factories, s. 112-, 2014.

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Kjellander, Marcus; Mazari, Aslam M.A.; Boman, Mats; Mannervik, Bengt et al.

Glutathione transferases immobilized on nanoporous alumina: Flow system kinetics, screening and stability

Ingår i Analytical Biochemistry, s. 59-63, 2014.

DOI Till DiVA

Modén, Olof; Mannervik, Bengt

Glutathione Transferases in the Bioactivation of Azathioprine

Ingår i REDOX AND CANCER PT A, s. 199-244, 2014.

DOI Till DiVA

Martin, M.; Anscombe, E.; Meschini, E.; Staunton, D. et al.

Identification and characterization of an irreversible inhibitor of CDK2

Ingår i European Journal of Cancer, s. 106-106, 2014.

DOI Till DiVA

Berglin, Lennart; Kjellander, Marcus; Johansson, Gunnar

In situ generation of iminodiacetic acid groups on nanoporous alumina for the reversible immobilization of enzymes and other biomolecules

Ingår i Biotechnology letters, s. 1819-1825, 2014.

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Sundell, Gustav; Ivarsson, Ylva

Interaction Analysis through Proteomic Phage Display

Ingår i BioMed Research International, s. 176172-, 2014.

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Dourado, Daniel F. A. R.; Fernandes, Pedro Alexandrino; Mannervik, Bengt; Ramos, Maria Joao

Isomerization of Delta(5)-Androstene-3,17-dione into Delta(4)-Androstene-3, 17-dione Catalyzed by Human Glutathione Transferase A3-3: A Computational Study Identifies a Dual Role for Glutathione

Ingår i Journal of Physical Chemistry A, s. 5790-5800, 2014.

DOI Till DiVA

Lampa, Anna; Bergman, Sara; Svahn Gustafsson, Sofia; Alogheli, Hiba et al.

Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Ingår i ACS Medicinal Chemistry Letters, s. 249-254, 2014.

DOI Till DiVA

Ehrenberg, Angelica

Novel Procedures for Identification and Characterization of Viral Proteases Inhibitors

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Seeger, Christian

Revealing Secrets of Synaptic Protein Interactions: A Biosensor based Strategy

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Toresson, Henrik

Steady state kinetics and regioselectivity for variants of StEH1 hydrolyzing different epoxide substrates

2014.

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Dobritzsch, Doreen; Wang, Huaming; Schneider, Gunter; Yu, Shukun

Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme

Ingår i Biochemical Journal, s. 441-452, 2014.

DOI Till DiVA

Blikstad, Cecilia; Dahlström, Käthe; Salminen, Tiina; Widersten, Mikael

Substrate scope and selectivity in offspring to an enzyme subjected to directed evolution

Ingår i The FEBS Journal, s. 2387-2398, 2014.

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Haugaard-Kedstrom, L. M.; Albertsen, L.; Gil, F. Abalde; Ivarsson, Ylva et al.

The Development and Characterization of a Peptide-Based Syntenin Inhibitor: Implacations for Cancer Metastasis

Ingår i Journal of Peptide Science, s. S39-S39, 2014.

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Manfroni, Giuseppe; Cannalire, Rolando; Barreca, Maria Letizia; Kaushik-Basu, Neerja et al.

The Versatile Nature of the 6-Aminoquinolone Scaffold: Identification of Submicromolar Hepatitis C Virus NS5B Inhibitors

Ingår i Journal of Medicinal Chemistry, s. 1952-1963, 2014.

DOI Till DiVA

Lampa, Anna; Alogheli, Hiba; Ehrenberg, Angelica E.; Åkerblom, Eva et al.

Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Ingår i Bioorganic & Medicinal Chemistry, s. 6595-6615, 2014.

DOI Till DiVA

Zhang, Wei; Mannervik, Bengt

An improved dual-tube megaprimer approach for multi-site saturation mutagenesis

Ingår i World Journal of Microbiology & Biotechnology, s. 667-672, 2013.

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Ragnarsson, Ulf; Grehn, Leif

Dual protection of amino functions involving Boc

Ingår i RSC Advances, s. 18691-18697, 2013.

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Christopeit, Tony; Øverbø, Kersti; Danielson, Helena; Nilsen, Inge W.

Efficient Screening of Marine Extracts for Protease Inhibitors by Combining FRET Based Activity Assays and Surface Plasmon Resonance Spectroscopy Based Binding Assays

Ingår i Marine Drugs, s. 4279-4293, 2013.

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Sun, Song; Zhang, Wei; Mannervik, Bengt; Andersson, Dan I.

Evolution of Broad Spectrum beta-Lactam Resistance in an Engineered Metallo-beta-lactamase

Ingår i Journal of Biological Chemistry, s. 2314-2324, 2013.

DOI Till DiVA

Musdal, Yaman; Hegazy, Usama M.; Aksoy, Yasemin; Mannervik, Bengt

FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1

Ingår i Chemico-Biological Interactions, s. 53-62, 2013.

DOI Till DiVA

Shibata, Aya; Nakano, Yukiko; Ito, Mika; Araki, Mika et al.

Fluorogenic probes using 4-substituted-2-nitrobenzenesulfonyl derivatives as caging groups for the analysis of human glutathione transferase catalyzed reactions

Ingår i The Analyst, s. 7326-7330, 2013.

DOI Till DiVA

Nordström, Helena

Fragment Based Drug Discovery with Surface Plasmon Resonance Technology

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Paredes, J. A.; Zhou, X.; Höglund, Stefan; Karlsson, A.

Gene Expression Deregulation in Postnatal Skeletal Muscle of TK2 Deficient Mice Reveals a Lower Pool of Proliferating Myogenic Progenitor Cells

Ingår i PLoS ONE, s. e53698-, 2013.

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Winquist, Johan; Geschwindner, Stefan; Xue, Yafeng; Gustavsson, Lars et al.

Identification of Structural-Kinetic and Structural-Thermodynamic Relationships for Thrombin Inhibitors

Ingår i Biochemistry, s. 613-626, 2013.

DOI Till DiVA

Poon, Jia-fei; Singh, Vijay P.; Engman, Lars

In Search of Catalytic Antioxidants-(Alkyltelluro)phenols, (Alkyltelluro)resorcinols, and Bis(alkyltelluro)phenols

Ingår i Journal of Organic Chemistry, s. 6008-6015, 2013.

DOI Till DiVA

Dourado, Daniel F. A. R.; Fernandes, Pedro Alexandrino; Ramos, Maria Joao; Mannervik, Bengt

Mechanism of Glutathione Transferase P1-1-Catalyzed Activation of the Prodrug Canfosfamide (TLK286, TELCYTA)

Ingår i Biochemistry, s. 8069-8078, 2013.

DOI Till DiVA

Modén, Olof

Mutational Analysis and Redesign of Alpha-class Glutathione Transferases for Enhanced Azathioprine Activity

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Kjellander, Marcus

Nanoporous Aluminum Oxide – A Promising Support for Modular Enzyme Reactors

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Löfling, Annica

Novel assay formats for improved immunoassay sensitivity in a minaturised CD-microlaboratory

2013.

Till DiVA

Winquist, Johan; Abdurakhmanov, Eldar; Baraznenok, Vera; Henderson, Ian et al.

Resolution of the Interaction Mechanisms and Characteristics of Non-nucleoside Inhibitors of Hepatitis C Virus Polymerase - Laying the Foundation for Discovery of Allosteric HCV Drugs

Ingår i Antiviral Research, s. 356-368, 2013.

DOI Till DiVA

Kjellander, Marcus; Gotz, Kathrin; Liljeruhm, Josefine; Boman, Mats et al.

Steady-state generation of hydrogen peroxide: kinetics and stability of alcohol oxidase immobilized on nanoporous alumina

Ingår i Biotechnology letters, s. 585-590, 2013.

DOI Till DiVA

Blikstad, Cecilia; Dahlström, Kärthe M.; Salminen, Tiina A.; Widersten, Mikael

Stereoselective oxidation of aryl-substituted vicinal diols into chiral α-hydroxy aldehydes by re-engineered propanediol oxidoreductase

Ingår i ACS Catalysis, s. 3016-3025, 2013.

DOI Till DiVA

Valegard, Karin; Iqbal, Aman; Kershaw, Nadia J.; Ivison, David et al.

Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway

Ingår i Acta Crystallographica Section D, s. 1567-1579, 2013.

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Valegard, Karin; Iqbal, Aman; Kershaw, Nadia J.; Ivison, David et al.

Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway

Ingår i Acta Crystallographica Section D, s. 1567-1579, 2013.

Till DiVA

Valegård, Karin; Iqbal, Aman; Kershaw, Nadia J.; Ivison, David et al.

Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway

Ingår i Acta Crystallographica Section D, s. 1567-1579, 2013.

DOI Till DiVA

Kesters, D.; Thompson, A. J.; Brams, M.; Van Elk, R. et al.

Structural basis of ligand recognition in 5-HT3 receptors

Ingår i EMBO Reports, s. 49-56, 2013.

DOI Till DiVA

Barreca, Maria Letizia; Manfroni, Giuseppe; Leyssen, Pieter; Winquist, Johan et al.

Structure-Based Discovery of Pyrazolobenzothiazine Derivatives As Inhibitors of Hepatitis C Virus Replication

Ingår i Journal of Medicinal Chemistry, s. 2270-2282, 2013.

DOI Till DiVA

Gossas, Thomas; Nordström, Helena; Xu, Ming-Hua; Sun, Zhi-Hua et al.

The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors: characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors

Ingår i MedChemComm, s. 432-442, 2013.

DOI Till DiVA

Gorny, Xenia; Mikhaylova, Marina; Seeger, Christian; Reddy, Pasham Parameshwar et al.

AKAP79/150 interacts with the neuronal calcium-binding protein caldendrin

Ingår i Journal of Neurochemistry, s. 714-726, 2012.

DOI Till DiVA

Gossas, Thomas; Vrang, Lotta; Henderson, Ian; Sedig, Susanne et al.

Aliskiren displays long-lasting interactions with human renin

Ingår i Naunyn-Schmiedeberg's Archives of Pharmacology, s. 219-224, 2012.

DOI Till DiVA

Seeger, Christian; Christopeit, Tony; Fuchs, K.; Grote, K. et al.

Corrigendum to "Histaminergic pharmacology of homo-oligomeric β3 γ-aminobutyric acid type A receptors characterized by surface plasmon resonance biosensor technology" (Biochemical Pharmacology (2012) 84 (341-351))

Ingår i Biochemical Pharmacology, s. 1541-, 2012.

DOI Till DiVA

Dominguez, Jose L.; Gossas, Thomas; Carmen Villaverde, M.; Danielson, U. Helena et al.

Experimental and 'in silico' analysis of the effect of pH on HIV-1 protease inhibitor affinity: Implications for the charge state of the protein ionogenic groups

Ingår i Bioorganic & Medicinal Chemistry, s. 4838-4847, 2012.

DOI Till DiVA

Eklund, Sandra; Lindås, Ann-Christin; Hamnevik, Emil; Widersten, Mikael et al.

Exploring the active site of tripeptidyl-peptidase II through studies of pH dependence of reaction kinetics

Ingår i Biochimica et Biophysica Acta - Proteins and Proteomics, s. 561-570, 2012.

DOI Till DiVA

Mannervik, Bengt

Five Decades with Glutathione and the GSTome

Ingår i Journal of Biological Chemistry, s. 6072-6083, 2012.

DOI Till DiVA

Seeger, Christian; Christopeit, Tony; Fuchs, Karoline; Grote, Katharina et al.

Histaminergic pharmacology of homo-oligomeric beta 3 gamma-aminobutyric acid type A receptors characterized by surface plasmon resonance biosensor technology

Ingår i Biochemical Pharmacology, s. 341-351, 2012.

DOI Till DiVA

Musdal, Y.; Ertan-Bolelli, T.; Bolelli, K.; Yilmaz, S. et al.

Inhibition of human glutathione transferase P1-1 by novel benzazole derivatives

Ingår i Türk Biyokimya Dergisi, s. 431-436, 2012.

DOI Till DiVA

Ragnarsson, Ulf; Grehn, Leif

Insights into sulfinate formation from tosyl hydrazides

Ingår i Tetrahedron Letters, s. 1045-1047, 2012.

DOI Till DiVA

Seeger, Christian; Gorny, Xenia; Reddy, Pasham Parameshwar; Seidenbecher, Constanze et al.

Kinetic and mechanistic differences in the interactions between caldendrin and calmodulin with AKAP79 suggest different roles in synaptic function

Ingår i Journal of Molecular Recognition, s. 495-503, 2012.

DOI Till DiVA

Zhang, Wei; Dourado, Daniel F. A. R.; Fernandes, Pedro; Ramos, Maria et al.

Multidimensional epistasis and fitness landscapes in enzyme evolution

Ingår i Biochemical Journal, s. 39-46, 2012.

DOI Till DiVA

Modén, Olof; Zhang, Wei; Mannervik, Bengt

Mutational analysis of human glutathione transferase A2-2 identifies structural elements supporting high activity with the prodrug azathioprine

Ingår i Protein Engineering Design & Selection, s. 189-197, 2012.

DOI Till DiVA

Janfalk Carlsson, Åsa; Bauer, Paul; Ma, Huan; Widersten, Mikael

Obtaining optical purity for product diols in enzyme-catalyzed epoxide hydrolysis: contributions from changes in both enantio- and regioselectivity

Ingår i Biochemistry, s. 7627-7637, 2012.

DOI Till DiVA

Winquist, Johan

Reducing Attrition via Improved Strategies for Pre-clinical Drug Discovery: SPR-biosensor Aided Interaction Studies

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Ito, Mika; Shibata, Aya; Zhang, Jie; Hiroshima, Michio et al.

Universal Caging Group for the in-Cell Detection of Glutathione Transferase Applied to 19F NMR and Bioluminogenic Probes

Ingår i ChemBioChem (Print), s. 1428-1432, 2012.

DOI Till DiVA

Christopeit, Tony; Stenberg, Gun; Gossas, Thomas; Nyström, Susanne et al.

A surface plasmon resonance-based biosensor with full-length BACE1 in a reconstituted membrane

Ingår i Analytical Biochemistry, s. 14-22, 2011.

DOI Till DiVA

Brunnström, Åsa; Hamberg, Mats; Griffiths, William J.; Mannervik, Bengt et al.

Biosynthesis of 14,15-Hepoxilins in Human L1236 Hodgkin Lymphoma Cells and Eosinophils

Ingår i Lipids, s. 69-79, 2011.

DOI Till DiVA

Fedulova, Natalia; Raffalli-Mathieu, Francoise; Mannervik, Bengt

Characterization of porcine Alpha-class glutathione transferase A1-1

Ingår i Archives of Biochemistry and Biophysics, s. 205-211, 2011.

DOI Till DiVA

Brandt, Peter; Geitmann, Matthis; Danielson, U Helena

Deconstruction of Non-Nucleoside Reverse Transcriptase Inhibitors of Human Immunodeficiency Virus Type 1 for Exploration of the Optimization Landscape of Fragments

Ingår i Journal of Medicinal Chemistry, 2011.

DOI Till DiVA

Zhang, Wei

Directed Evolution of Glutathione Transferases with Altered Substrate Selectivity Profiles: A Laboratory Evolution Study Shedding Light on the Multidimensional Nature of Epistasis

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Fedulova, Natalia; Mannervik, Bengt

Experimental Conditions Affecting Functional Comparison of Highly Active Glutathione Transferases

Ingår i Analytical Biochemistry, s. 16-23, 2011.

DOI Till DiVA

Elinder, Malin; Geitmann, Matthis; Gossas, Thomas; Källblad, Per et al.

Experimental Validation of a Fragment Library for Lead Discovery Using SPR Biosensor Technology

Ingår i Journal of Biomolecular Screening, s. 15-25, 2011.

DOI Till DiVA

Lopes Pinto, Fernando; Erasmie, Sven; Blikstad, Cecilia; Lindblad, Peter et al.

FtsZ degradation in the cyanobacterium Anabaena sp. strain PCC 7120

Ingår i Journal of plant physiology (Print), s. 1934-1942, 2011.

DOI Till DiVA

Geitmann, Matthis; Elinder, Malin; Seeger, Christian; Brandt, Peter et al.

Identification of a Novel Scaffold for Allosteric Inhibition of Wild Type and Drug Resistant HIV-1 Reverse Transcriptase by Fragment Library Screening

Ingår i Journal of Medicinal Chemistry, s. 699-708, 2011.

DOI Till DiVA

Eklund, Sandra

Interpreting a Giant: Studies of Structure and Function of Tripeptidyl-peptidase II

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Geitmann, Matthis; Dahl, Göran; Danielson, U. Helena

Mechanistic and kinetic characterization of hepatitis C virus NS3 protein interactions with NS4A and protease inhibitors

Ingår i Journal of Molecular Recognition, s. 60-70, 2011.

DOI Till DiVA

Cassimjee, Karim Engelmark; Kourist, Robert; Lindberg, Diana; Wittrup Larsen, Marianne et al.

One-step enzyme extraction and immobilization for biocatalysis applications

Ingår i Biotechnology Journal, s. 463-469, 2011.

DOI Till DiVA

Tegler, Lotta T.; Nonglaton, Guillaume; Büttner, Frank; Caldwell, Karin et al.

Powerful protein binders from designed polypeptides and small organic molecules: a general concept for protein recognition

Ingår i Angewandte Chemie International Edition, s. 1823-1827, 2011.

DOI Till DiVA

Gustafsson, Sofia S.; Vrang, Lotta; Terelius, Ylva; Danielson, Helena

Quantification of interactions between drug leads and serum proteins by use of "binding efficiency"

Ingår i Analytical Biochemistry, s. 163-175, 2011.

DOI Till DiVA

Larsson, Emilia; Mannervik, Bengt; Raffalli-Mathieu, Francoise

Quantitative and selective polymerase chain reaction analysis of highly similar human alpha-class glutathione transferases

Ingår i Analytical Biochemistry, s. 96-101, 2011.

DOI Till DiVA

Lindberg, Diana; de la Fuente Revenga, Mario; Widersten, Mikael

Deep eutectic solvents (DESs) are viable cosolvents for enzyme-catalyzed epoxide hydrolysis

Ingår i Journal of Biotechnology, s. 169-171, 2010.

DOI Till DiVA

Retra, Kim; Geitmann, Matthis; Kool, Jeroen; Smit, August B et al.

Development of surface plasmon resonance biosensor assays for primary and secondary screening of acetylcholine binding protein ligands

Ingår i Analytical Biochemistry, s. 58-64, 2010.

DOI Till DiVA

Örtqvist, Pernilla; Gising, Johan; Ehrenberg, Angelica; Vema, Aparna et al.

Discovery of Achiral Inhibitors of the Hepatitis C Virus NS3 Protease based on 2(1H)-pyrazinones

Ingår i Bioorganic & Medicinal Chemistry, s. 6512-6525, 2010.

DOI Till DiVA

Lampa, Anna; Ehrenberg, Angelica E.; Gustafsson, Sofia S.; Vema, Aparna et al.

Improved P2 phenylglycine-based hepatitis C virus NS3 protease inhibitors with alkenylic prime-side substituents

Ingår i Bioorganic & Medicinal Chemistry, s. 5413-5424, 2010.

DOI Till DiVA

Geitmann, Matthis; Retra, Kim; de Kloe, Gerdien E; Homan, Evert et al.

Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein

Ingår i Biochemistry, s. 8143-8154, 2010.

DOI Till DiVA

Ghasemzadeh, Nasim; Tore W. Wilhelmsen, Tore W.; Nyberg, Fred; Hjertén, Stellan

Precautions to improve the accuracy of quantitative determinations of biomarkers in clinical diagnostics

Ingår i Electrophoresis, s. 2722-2729, 2010.

DOI Till DiVA

Örtqvist, Pernilla; Vema, Aparna; Ehrenberg, Angelica E; Dahl, Göran et al.

Structure-activity relationships of HCV NS3 protease inhibitors evaluated on the drug-resistant variants A156T and D168V

Ingår i Antiviral Therapy, s. 841-852, 2010.

DOI Till DiVA

de Kloe, Gerdien E; Retra, Kim; Geitmann, Matthis; Källblad, Per et al.

Surface Plasmon Resonance Biosensor Based Fragment Screening Using Acetylcholine Binding Protein Identifies Ligand Efficiency Hot Spots (LE Hot Spots) by Deconstruction of Nicotinic Acetylcholine Receptor α7 Ligands

Ingår i Journal of Medicinal Chemistry, s. 7192-7201, 2010.

DOI Till DiVA

Lindberg, Diana; de la Fuente Revenga, Mario; Widersten, Mikael

Temperature and pH dependence of enzyme catalyzed hydrolysis of trans-methylstyrene oxide: a unifying kinetic model for observed hysteresis, cooperativity and regioselectivity

Ingår i Biochemistry, s. 2297-2304, 2010.

DOI Till DiVA

Mannervik, Bengt; Rúnarsdóttir, Arna

The quest for molecular quasi-species in ligand-activity space and its application to directed enzyme evolution

Ingår i FEBS Letters, s. 2565-2571, 2010.

DOI Till DiVA

Danielson, U Helena

Fragment library screening and lead characterization using SPR biosensors

Ingår i Current Topics in Medicinal Chemistry, s. 1725-1735, 2009.

DOI Till DiVA

Patrick, Ferdinandi; Mtui, Godliving; Mshandete, Anthony; Johansson, Gunnar et al.

Purification and characterization of a laccase from the basidiomycete Funalia trogii (Berk.) isolated in Tanzania

Ingår i African Journal of Biochemistry Research, s. 250-259, 2009.

Till DiVA

Filonova, Lada; Kallas, Åsa; Greffe, Lionel; Johansson, Gunnar et al.

Analysis of the Surfaces of Wood Tissues and Pulp Fibers Using Carbohydrate-Binding Modules Specific for Crystalline Cellulose and Mannan

Ingår i Biomacromolecules, s. 91-97, 2007.

Till DiVA

Raffalli-Mathieu, Francoise; Persson, David; Mannervik, Bengt

Differences between bovine and human steroid double-bond isomerase activities of Alpha-class glutathione transferases selectively expressed in steroidogenic tissues

Ingår i Biochimica et Biophysica Acta - General Subjects, s. 130-136, 2007.

DOI Till DiVA

Söderberg, Malin; Raffalli-Mathieu, Françoise; Lang, Matti A.

Identification of a regulatory cis-element within the 3 '-untranslated region of the murine inducible nitric oxide synthase (NOS) mRNA: interaction with heterogeneous nuclear ribonucleoproteins I and L and role in the NOS gene expression

Ingår i Molecular Immunology, s. 434-442, 2007.

DOI Till DiVA

Nurbo, Johanna; Dahl, G; Danielson, U Helena; Sandström, Anja

Investigation of beta-amino acids as building blocks in hepatitis c virus NS3 protease inhibitors

2007.

Till DiVA

Abdurahman, Samir; Höglund, Stefan; Höglund, Anders; Vahlne, Anders

Mutation in the loop C-terminal to the cyclophilin A binding site of HIV-1 capsid protein disrupts proper virus assembly and infectivity

Ingår i Retrovirology, s. 19-, 2007.

DOI Till DiVA

Ivarsson, Ylva; Norrgård, Malena A; Tars, Kaspar; Mannervik, Bengt

A positively selected residue influences enzyme functionalities

Ingår i The FASEB Journal, s. A474-, 2006.

Till DiVA

Park, Hee-Sung; Nam, Sung-Hun; Lee, Jin Kak; Yoon, Chang No et al.

Design and evolution of new catalytic activity with an existing protein scaffold.

Ingår i Science, s. 535-8, 2006.

Till DiVA

Kurtovic, Sanela; Emrén, Lars O; Runarsdottír, Arna; Larsson, Anna-Karin et al.

Identification of functionally diverging quasi-species in molecular enzyme evolution

Ingår i The FASEB Journal, s. A470-, 2006.

Till DiVA

Simonsson, Ulrika S.H.; Lindell, Monica; Raffalli-Mathieu, Francoise; Lannerbro, Angela et al.

In vivo and mechanistic evidence of nuclear receptor CAR induction by artemisinin

Ingår i European Journal of Clinical Investigation, s. 647-653, 2006.

DOI Till DiVA

Sookkongwaree, K; Geitmann, Matthis; Roengsumran, S; Petsom, A et al.

Inhibition of viral proteases by Zingiberaceae extracts and flavones isolated from Kaempferia parviflora

Ingår i Pharmazie, s. 717-721, 2006.

Till DiVA

Liljestrand, Johan

Interaction, Organisation, Tasks and Possibilities for Learning about Mathematical Relationships:: A Swedish Classroom Compared with a US Classroom

2006.

Till DiVA

Ellfolk, Maria; Norlin, Maria; Wikvall, Kjell

Isolation and properties of the CYP2D25 promoter: Transcriptional regulation by vitamin D3 metabolites

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 568-572, 2006.

DOI Till DiVA

Barman, Jharna; Acharya, Sandipta; Zhou, Chuanzheng; Chatterjee, Subhrangsu et al.

Non-identical electronic characters of the internucleotidic phosphates in RNA modulate the chemical reactivity of the phosphodiester bonds.

Ingår i Org Biomol Chem, s. 928-41, 2006.

Till DiVA

Josephy, P. David; Taylor, Patricia L.; Vervaet, Gaby; Mannervik, Bengt

Screening and characterization of variant Theta-class glutathione transferases catalyzing the activation of ethylene dibromide to a mutagen

Ingår i Environmental and Molecular Mutagenesis, s. 657-665, 2006.

DOI Till DiVA

Gutierrez Arenas, Omar; Danielson, U Helena

Sensitivity analysis and error structure of progress curves

Ingår i Analytical Biochemistry, s. 1-10, 2006.

DOI Till DiVA

Takatsy, Aniko; Kilár, Aniko; Kilár, Ferenc; Hjertén, Stellan

Universal method for synthesis of artificial gel antibodies by the imprinting approach combined with a unique electrophoresis technique for detection of minute structural differences of proteins, viruses and cells (bacteria): Ia. Gel antibodies against proteins (transferrins)

Ingår i Journal of Separation Science, s. 2802-2809, 2006.

DOI Till DiVA

Takatsy, Aniko; Sedzik, Jan; Kilar, Ferenc; Hjertén, Stellan

Universal method for synthesis of artificial gel antibodies by the imprinting approach combined with a unique electrophoresis technique for detection of minute structural differences of proteins, viruses, and cells (bacteria): II. Gel antibodies against virus (Semliki Forest Virus)

Ingår i Journal of Separation Science, s. 2810-2815, 2006.

DOI Till DiVA

Bacskay, Ivett; Takatsy, Aniko; Vegvari, Akos; Elfwing, Anders et al.

Universal method for synthesis of artificial gel antibodies by the imprinting approach combined with a unique electrophoresis technique for detection of minute structural differences of proteins, viruses, and cells (bacteria). III: Gel antibodies against cells (bacteria)

Ingår i Electrophoresis, s. 4682-4687, 2006.

DOI Till DiVA

Eklund, Birgitta; Elfarra, Adnan A.; Mannervik, Bengt

Activation of anticancer prodrugs by human glutathione transferases

Ingår i FEBS Journal, s. 546 Suppl-, 2005.

Till DiVA

Elfström, Lisa; Widersten, Mikael

Catalysis of potato epoxide hydrolase, StEH1

Ingår i Biochemical Journal, s. 633-640, 2005.

DOI Till DiVA

Akoachere, Monique; Iozef, Rimma; Rahlfs, Stefan; Deponte, Marcel et al.

Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts.

Ingår i Biol Chem, s. 41-52, 2005.

Till DiVA

Johansson, Emma; Engvall, Caroline; Arfvidsson, Maria; Lundahl, Per et al.

Development and initial evaluation of PEG-stabilized disks as novel model membranes

Ingår i Biophysical Chemistry, s. 183-192, 2005.

DOI Till DiVA

Kurtovic, Sanela; Runarsdottir, Arna; Larsson, Anna-Karin; Emrén, Lars O et al.

Diverging substrate specificites from a glutathione transferase library analyzed by multivariate methods

Ingår i FEBS Journal, s. 90 Suppl-, 2005.

Till DiVA

Andersson, Malena; Mannervik, Bengt

Exploring protein evolution by saturation mutagenesis of the GST M2-2 active site residue 210

Ingår i FEBS Journal, s. 81 Suppl-, 2005.

Till DiVA

Ivarsson, Ylva; Mannervik, Bengt

Exploring the importance of an active site residue on the stereo and regio selectivity of Mu class glutathione transferases

Ingår i FEBS Journal, s. 88 Suppl-, 2005.

Till DiVA

Raffalli-Mathieu, Francoise; Mannervik, Bengt

Human glutathione transferase A3-3 active as steroid double-bond isomerase

Ingår i Methods of Enzymology, s. 265-278, 2005.

Till DiVA

Lindås, Ann-Christin; Tomkinson, Birgitta

Identification and characterization of the promoter for the gene encoding human tripeptidyl-peptidase II.

Ingår i Gene, s. 249-57, 2005.

Till DiVA

Jonas, Kristina; Van Der Vries, Erhard; Nilsson, Mikael T.I.; Widersten, Mikael

Isolation of novel single-chain Cro proteins targeted for binding to the bcl-2 transcription initiation site by repertoire selection and subunit combinatorics

Ingår i Protein Engineering Design & Selection, s. 537-546, 2005.

DOI Till DiVA

Stavropoulou, Vaia; Xie, Jianjun; Henriksson, Marie; Tomkinson, Birgitta et al.

Mitotic infidelity and centrosome duplication errors in cells overexpressing tripeptidyl-peptidase II.

Ingår i Cancer Res, s. 1361-8, 2005.

Till DiVA

Mannervik, Bengt; Board, Philip G; Hayes, John D; Listowsky, Irving et al.

Nomenclature for mammalian soluble glutathione transferases

Ingår i Methods of Enzymology, s. 1-8, 2005.

Till DiVA

Rönn, Robert; Gossas, T; Sabnis, Y A; Åkerblom, E et al.

Novel C-terminal functionalities in hepatitis C virus NS3 protease inhibitors

2005.

Till DiVA

Mannervik, Bengt

Optimizing the heterologous expression of glutathione transferase

Ingår i Methods of Enzymology, s. 254-265, 2005.

Till DiVA

Edalat, Maryam H; Mannervik, Bengt

Peptide phage display for probing GST-protein interactions.

Ingår i Methods Enzymol, s. 354-67, 2005.

Till DiVA

Kipper, Kalle; Väljamäe, Priit; Johansson, Gunnar

Processive action of cellobiohydrolase Cel7A from Trichoderma reesei is revealed as a

Ingår i Biochemical Journal, s. 1-9, 2005.

Till DiVA

Ivarsson, Ylva; Mannervik, Bengt

Regio- and enantioselectivities in epoxide conjugations are modulated by residue 210 in Mu class glutathione transferases.

Ingår i Protein Eng Des Sel, s. 607-16, 2005.

Till DiVA

Shokeer, Abeer; Larsson, Anna-Karin; Mannervik, Bengt

Residue 234 in glutathione transferase T1-1 plays a pivotal role in the catalytic activity and the selectivity against alternative substrates

Ingår i Abstracts of the 30th FEBS Congress, s. 99 Suppl-, 2005.

DOI Till DiVA

Shokeer, Abeer; Larsson, Anna-Karin; Mannervik, Bengt

Residue 234 in glutathione transferase T1-1 plays a pivotal role in the catalytic activity and the selectivity against alternative substrates

Ingår i Biochemical Journal, s. 387-92, 2005.

DOI Till DiVA

Hegazy, Usama; Mannervik, Bengt

Site-directed substitution of the key residue at the subunit interface of GST P1-1 by S-alkylcysteine residues sustains glutathione binding and catalytic activity of the enzyme

Ingår i FEBS Journal, s. 87 Suppl-, 2005.

Till DiVA

Elfström, Lisa; Widersten, Mikael

The Saccharomyces cerevisiae ORF YNR064c protein has characteristics of an 'orphaned' epoxide hydrolase

Ingår i Biochimica et Biophysica Acta - Proteins and Proteomics, s. 213-221, 2005.

DOI Till DiVA

Tomkinson, Birgitta; Lindås, Ann-Christin

Tripeptidyl-peptidase II: a multi-purpose peptidase.

Ingår i Int J Biochem Cell Biol, s. 1933-7, 2005.

Till DiVA

Hederos, Sofia; Broo, Kerstin; Jakobsson, Emma; Kleywegt, Gerard J et al.

A new enzyme by rational design - the incorporation of a single His residue enables efficient thioester hydrolysis by human glutathione transferase A1-1

Ingår i Proc. Nat. Acad. Sci., s. 13163-13167, 2004.

Till DiVA

Nilsson, Mikael; Johansson, Gunnar; Isaksson, Roland

Determination of affinity constants by competitive binding in partial filling capillary electrophoresis

Ingår i Electrophoresis, s. 1022-1027, 2004.

Till DiVA

Shuman, Cynthia; Vrang, Lotta; Danielson, U. Helena

Improved structure-activity relationship analysis of HIV-1 protease inhibitors using interaction kinetic data

Ingår i Journal of Medicinal Chemistry, s. 5953-61, 2004.

DOI Till DiVA

Hederos, Sofia; Broo, Kerstin S; Jakobsson, Emma; Kleywegt, Gerard J et al.

Incorporation of a single His residue by rational design enables thiol-ester hydrolysis by human glutathione transferase A1-1.

Ingår i Proc Natl Acad Sci U S A, s. 13163-7, 2004.

Till DiVA

Wisén, Susanne; Bergman, Birgitta; Mannervik, Bengt

Mutagenesis of the cysteine residues in the transcription factor NtcA from Anabaena PCC 7120 and its effects on DNA binding in vitro.

Ingår i Biochim Biophys Acta, s. 156-63, 2004.

Till DiVA

Poliakov, Anton; Johansson, A; Åkerblom, E; Lindeberg, G et al.

Optimisation of peptide-based inhibitors of full-length hepatitis C virus NS3 protease

2004.

Till DiVA

Nilsson, Mikael T.I.; Widersten, Mikael

Repertoire selection of variant single-chain Cro: towards directed DNA-binding specificity of helix-turn-helix proteins

Ingår i Biochemistry, s. 12038-12047, 2004.

DOI Till DiVA

Edalat, Maryam; Mannervik, Bengt; Axelsson, Lars-Göran

Selective expression of detoxifying glutathione transferases in mouse colon: effect of experimental colitis and the presence of bacteria.

Ingår i Histochem Cell Biol, s. 151-9, 2004.

Till DiVA

Tomkinson, Birgitta

Tripeptidyl-peptidase II

Ingår i Handbook of proteolytic enzymes, s. 1882-1885, 2004.

Till DiVA

Beyer, B; Rubin, J; Johnson, J; Chung, A et al.

Candida albicans secreted aspartic peptidase specificity: A chromogenic combinatorial approach

Ingår i Biopolymers, s. 310-P025, 2003.

Till DiVA

Raices, Manuel; Montesino, Raquel; Cremata, Jose; Szabó, István et al.

Cellobiose Quinone Oxidoreductase from the white rot fungus Phanerochaete chrysosporium is produced by intracellular proteolysis of Cellobiose Dehydrogenase.

Ingår i Biochimica et Biophysica Acta: Gene Structure and expression, s. 15-22, 2002.

Till DiVA

Bodin, Karl; Andersson, Ulla; Rystedt, Eva; Ellis, Eva et al.

Metabolism of 4 beta -hydroxycholesterol in humans

Ingår i Journal of Biological Chemistry, s. 31534-31540, 2002.

DOI Till DiVA

Henriksson, Hongbin; Pettersson, Göran; Johansson, Gunnar

Discrimination between enantioselective and non-selective binding sites on cellobiohydrolase-based stationary phases by selective displacers

Ingår i Journal of Chromatography A, s. 107-115, 1999.

Till DiVA

Danielson, U. Helena; Jiang, Fanyi Y; Hansson, Lars O.; Mannervik, Bengt

Probing the kinetic mechanism and coenzyme specificity of glutathione reductase from the cyanobacterium Anabaena PCC 7120 by redesign of the pyridine-nucleotide-binding site

Ingår i Biochemistry, s. 9254-9263, 1999.

DOI Till DiVA

Tomkinson, Birgitta

Tripeptidyl peptidases: enzymes that count.

Ingår i Trends Biochem Sci, s. 355-9, 1999.

Till DiVA

Karlsson, E; Harvey, A L; Cervenansky, C; Kleywegt, G J et al.

Fasciculins, cholinesterase inhibitors from mamba venoms

Ingår i Enzymes from snake venom, s. 633-688, 1998.

Till DiVA

Väljamäe, Priit; Sild, Veljo; Pettersson, Göran; Johansson, Gunnar

The Initial Kinetics of Hydrolysis by Cellobiohydrolases I and II is Consistent with a Cellulose Surface-Erosion Model

Ingår i European Journal of Biochemistry, s. 469-475, 1998.

Till DiVA

Kolm, Rüdiger H.; Danielson, U Helena; Zhang, Y.uesheng; Talalay, Paul et al.

Isothiocyanates as substrates for human glutathione transferases: structure-activity studies

Ingår i Biochemical Journal, s. 453-459, 1995.

Till DiVA

Loog, Mart; Eller, Marika; Ekman, Pia; Engström, Lorentz et al.

Comparision of substrate specificities of protein kinases A and C based on peptide substrates

Ingår i Bioorganic chemistry (Print), s. 328-336, 1994.

DOI Till DiVA

Toomik, Reet; Eller, Marika; Ekman, Pia; Ragnarsson, Ulf et al.

D-amino acid residues as substrate specificity determinants for casein kinase II

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 1564-1569, 1994.

DOI Till DiVA

Chaga, Grigoriy; Widersten, Mikael; Andersson, Lennart; Porath, Jerker et al.

Engineering of a metal coordinating site into human glutathione transferase M1-1 based on immobilized metal ion affinity chromatography of homologous rat enzymes

Ingår i Protein Engineering, s. 1115-1119, 1994.

DOI Till DiVA

Toomik, Reet; Ekman, Pia; Eller, Marika; Järv, Jaak et al.

Protein kinase assay using tritiated peptide substrates and ferric adsorbent paper for phosphopeptide binding

Ingår i Analytical Biochemistry, s. 348-353, 1993.

DOI Till DiVA

Eller, Marika; Järv, Jaak; Toomik, Reet; Ragnarsson, Ulf et al.

Substrate specificity of protein kinase C studied with peptides containing D-amino acid residues.

Ingår i Journal of Biochemistry, s. 177-180, 1993.

Till DiVA

Sinning, I; Kleywegt, G J; Mannervik, B; Board, P G et al.

The active site in class alpha glutathione transferases

Ingår i Structure and Function of Glutathione Transferases, s. 75-85, 1993.

Till DiVA

Muszynska, Grazyna; Dobrowolska, Grazyna; Medin, Anders; Ekman, Pia et al.

Model studies on iron (III) ion affinity chromatography: II. Interaction of immobilized ferric ions with phosphorylated amino acids, peptides and proteins

Ingår i Journal of Chromatography A, s. 19-28, 1992.

DOI Till DiVA

Eller, Marika; Järv, Jaak; Toomik, Reet; Ragnarsson, Ulf et al.

Peptide fragments of myelin basic protein as substrates of protein kinase C.

Ingår i Biochemistry International, s. 625-631, 1992.

Till DiVA

Ekman, Pia; Eller, Marika; Ragnarsson, Ulf; Engström, Lorentz

Two methods to avoid the effect of endogenous inhibitors during the assay of protein kinase C activity in tissue extracts.

Ingår i Preparative Biochemistry, s. 165-175, 1992.

DOI Till DiVA

Eller, Marika; Sepp, A; Toomik, Reet; Ekman, Pia et al.

Studies on the substrate specificity of cAMP-dependent protein kinase using diastereomeric peptides

Ingår i Biochemistry International, s. 453-460, 1991.

Till DiVA

Neuzil, Jiri; Danielson, Helena; Welch, G Rickey; Ovádi, Judit

Cooperative effect of fructose bisphosphate and glyceraldehyde-3-phosphate dehydrogenase on aldolase action

Ingår i Biochimica et Biophysica Acta, s. 307-312, 1990.

DOI Till DiVA

Wallin, Margareta; Deinum, Johanna; Goobar, Laura; Danielson, U Helena

Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases

Ingår i Journal of General Virology, s. 1985-1991, 1990.

DOI Till DiVA

Gogoll, Adolf; Oscarsson, Sven

Reaction of pyridine derivatives with butyl glycidyl ether as a model system for glycidyl ether modified agarose: structural assignment by selective inept spectra

Ingår i Tetrahedron, s. 2539-2548, 1990.

DOI Till DiVA

Mannervik, Bengt; Danielson, U Helena

Glutathione transferases - structure and catalytic activity

Ingår i Crc Critical Reviews in Biochemistry, s. 283-337, 1988.

Till DiVA

Danielson, U Helena; Mannervik, Bengt

Paradoxical inhibition of rat glutathione transferase 4-4 by indomethacin explained by substrate-inhibitor-enzyme complexes in a random-order sequential mechanism

Ingår i Biochemical Journal, s. 705-711, 1988.

Till DiVA

Principato, Giovanni B; Danielson, U Helena; Mannervik, Bengt

Relaxed thiol substrate specificity of glutathione transferase effected by a non-substrate glutathione derivative

Ingår i FEBS Letters, s. 155-158, 1988.

DOI Till DiVA

Mannervik, Bengt; Castro, Victor M; Danielson, U Helena; Platz, A et al.

Expression of class-pi glutathione transferase in drug-resistant human-melanoma cells

Ingår i Proceedings of the American Association of Cancer Research, s. 5-5, 1987.

Till DiVA

Danielson, U Helena; Esterbauer, Hermann; Mannervik, Bengt

Structure-activity relationships of 4-hydroxyalkenals in the conjugation catalysed by mammalian glutathione transferases

Ingår i Biochemical Journal, s. 707-713, 1987.

Till DiVA

Danielson, U Helena; Mannervik, Bengt

Kinetic independence of the subunits of cytosolic glutathione transferase from the rat

Ingår i Biochemical Journal, s. 263-267, 1985.

Till DiVA

Ålin, Per; Jensson, Helgi; Guthenberg, Claes; Danielson, U Helena et al.

Purification of major basic glutathione transferase isoenzymes from rat liver by use of affinity chromatography and fast protein liquid chromatofocusing

Ingår i Analytical Biochemistry, s. 313-320, 1985.

DOI Till DiVA

Mannervik, Bengt; Ålin, P; Danielson, U Helena; Guthenberg, C et al.

STRUCTURAL DATA AND ENZYMATIC-PROPERTIES DEFINING 3 CLASSES OF MAMMALIAN CYTOSOLIC GLUTATHIONE TRANSFERASE

Ingår i Federation proceedings, s. 471-471, 1985.

Till DiVA

Humble, Elisabet; Dahlqvist-Edberg, Ulla; Ek, Pia; Netzel, Elvy et al.

Amino acid sequence at the phosphorylated site of rat liver fructose-1,6-diphosphatase and phosphorylation of a corresponding synthetic peptide

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 1064-1072, 1979.

DOI Till DiVA

Winquist, Johan; Nordström, Helena; Geitmann, Matthis; Gossas, Thomas et al.

New Scaffolds for Design of Inhibitors of Drug Resistant HIV-1 Protease Identified by Fragment Library Screening

Till DiVA

Maurer, Dirk; Enugala, Thilak Reddy; Hamnevik, Emil; Bauer, Paul et al.

Stereoselectivity in Catalyzed Transformation of a 1,2-Disubstituted Vicinal Diol and the Corresponding Diketone by Wild Type and Laboratory Evolved Alcohol Dehydrogenases

Till DiVA