Publikationer i Doreen Dobritzsch grupp

Engineered Aldolases Catalyzing Stereoselective Aldol Reactions Between Aryl-Substituted Ketones and Aldehydes

Cornelius Chukwu, Eugenia; Bartl, Michael; Persson, Louise J.; Xiong, Ruisheng et al.

Ingår i Catalysis Science & Technology, 2023.

DOI för Engineered Aldolases Catalyzing Stereoselective Aldol Reactions Between Aryl-Substituted Ketones and Aldehydes Ladda ner fulltext (pdf) av Engineered Aldolases Catalyzing Stereoselective Aldol Reactions Between Aryl-Substituted Ketones and Aldehydes

Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs

Mihalič, Filip; Simonetti, Leandro; Giudice, Girolamo; Rubin Sander, Marie et al.

Ingår i Nature Communications, 2023.

DOI för Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs Ladda ner fulltext (pdf) av Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs

Antibodies to Cartilage Oligomeric Matrix Protein Are Pathogenic in Mice and May Be Clinically Relevant in Rheumatoid Arthritis

Ge, Changrong; Tong, Dongmei; Loennblom, Erik; Liang, Bibo et al.

Ingår i Arthritis & Rheumatology, s. 961-971, 2022.

DOI för Antibodies to Cartilage Oligomeric Matrix Protein Are Pathogenic in Mice and May Be Clinically Relevant in Rheumatoid Arthritis Ladda ner fulltext (pdf) av Antibodies to Cartilage Oligomeric Matrix Protein Are Pathogenic in Mice and May Be Clinically Relevant in Rheumatoid Arthritis

beta-Ureidopropionase deficiency due to novel and rare UPB1 mutations affecting pre-mRNA splicing and protein structural integrity and catalytic activity

Dobritzsch, Doreen; Meijer, Judith; Meinsma, Rutger; Maurer, Dirk et al.

Ingår i Molecular Genetics and Metabolism, s. 177-185, 2022.

DOI för beta-Ureidopropionase deficiency due to novel and rare UPB1 mutations affecting pre-mRNA splicing and protein structural integrity and catalytic activity Ladda ner fulltext (pdf) av beta-Ureidopropionase deficiency due to novel and rare UPB1 mutations affecting pre-mRNA splicing and protein structural integrity and catalytic activity

Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor

Ge, Changrong; Weisse, Sylvia; Xu, Bingze; Dobritzsch, Doreen et al.

Ingår i Annals of the Rheumatic Diseases, s. 480-489, 2022.

DOI för Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor Ladda ner fulltext (pdf) av Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor

Co-therapy with S-adenosylmethionine and nicotinamide riboside improves t-cell survival and function in Arts Syndrome (PRPS1 deficiency)

Lenherr, Nina; Christodoulou, John; Duley, John; Dobritzsch, Doreen et al.

Ingår i Molecular Genetics and Metabolism Reports, 2021.

DOI för Co-therapy with S-adenosylmethionine and nicotinamide riboside improves t-cell survival and function in Arts Syndrome (PRPS1 deficiency) Ladda ner fulltext (pdf) av Co-therapy with S-adenosylmethionine and nicotinamide riboside improves t-cell survival and function in Arts Syndrome (PRPS1 deficiency)

Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase

Talibov, Vladimir O; Fabini, Edoardo; FitzGerald, Edward; Tedesco, Daniele et al.

Ingår i ChemBioChem (Print), s. 1597-1608, 2021.

DOI för Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase Ladda ner fulltext (pdf) av Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase

Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

FitzGerald, Edward A.; Butko, Margaret T.; Boronat, Pierre; Cederfelt, Daniela et al.

Ingår i RSC Advances, s. 7527-7537, 2021.

DOI för Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor Ladda ner fulltext (pdf) av Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

Atypical presentation of Arts syndrome due to a novel hemizygous loss-of-function variant in the PRPS1 gene

Puusepp, Sanna; Reinson, Karit; Pajusalu, Sander; van Kuilenburg, Andre B. P. et al.

Ingår i Molecular Genetics and Metabolism Reports, 2020.

DOI för Atypical presentation of Arts syndrome due to a novel hemizygous loss-of-function variant in the PRPS1 gene Ladda ner fulltext (pdf) av Atypical presentation of Arts syndrome due to a novel hemizygous loss-of-function variant in the PRPS1 gene

Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1

Yang, Jie; Talibov, Vladimir O; Peintner, Stefan; Rhee, Claire et al.

Ingår i ACS Omega, s. 3979-3995, 2020.

DOI för Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1 Ladda ner fulltext (pdf) av Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1

Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS

van Kuilenburg, Andre B. P.; Tarailo-Graovac, Maja; Richmond, Phillip A.; Drogemoller, Britt I. et al.

Ingår i New England Journal of Medicine, s. 1433-1441, 2019.

DOI för Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS

Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies

Ge, Changrong; Xu, Bingze; Liang, Bibo; Lönnblom, Erik et al.

Ingår i Arthritis & Rheumatology, s. 210-221, 2019.

DOI för Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies

Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism

Maurer, Dirk; Lohkamp, Bernhard; Krumpel, Michael; Widersten, Mikael et al.

Ingår i Biochemical Journal, s. 2395-2416, 2018.

DOI för Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism

Directed Evolution of Alcohol Dehydrogenase for Improved Stereoselective Redox Transformations of 1-Phenylethane-1,2-Diol and Its Corresponding Acyloin

Hamnevik, Emil; Maurer, Dirk; Enugala, Thilak Reddy; Chu, Thao et al.

Ingår i Biochemistry, s. 1059-1062, 2018.

DOI för Directed Evolution of Alcohol Dehydrogenase for Improved Stereoselective Redox Transformations of 1-Phenylethane-1,2-Diol and Its Corresponding Acyloin

Epoxide Hydrolysis as a Model System for Understanding Flux Through a Branched Reaction Scheme

Janfalk Carlsson, Åsa; Bauer, Paul; Dobritzsch, Doreen; Kamerlin, Shina C Lynn et al.

Ingår i IUCrJ, s. 269-282, 2018.

DOI för Epoxide Hydrolysis as a Model System for Understanding Flux Through a Branched Reaction Scheme Ladda ner fulltext (pdf) av Epoxide Hydrolysis as a Model System for Understanding Flux Through a Branched Reaction Scheme

Genome sequencing reveals a novel genetic mechanism underlying dihydropyrimidine dehydrogenase deficiency: A novel missense variant c.1700G > A and a large intragenic inversion in DPYD spanning intron 8 to intron 12

van Kuilenburg, André; Tarailo-Graovac, Maja; Meijer, Judith; Drogemoller, Britt et al.

Ingår i Human Mutation, s. 947-953, 2018.

DOI för Genome sequencing reveals a novel genetic mechanism underlying dihydropyrimidine dehydrogenase deficiency: A novel missense variant c.1700G > A and a large intragenic inversion in DPYD spanning intron 8 to intron 12

Stereo- and Regioselectivity in Catalyzed Transformation of a 1,2-Disubstituted Vicinal Diol and the Corresponding Diketone by Wild Type and Laboratory Evolved Alcohol Dehydrogenases

Maurer, Dirk; Enugala, Thilak Reddy; Hamnevik, Emil; Bauer, Paul et al.

Ingår i ACS Catalysis, s. 7526-7538, 2018.

DOI för Stereo- and Regioselectivity in Catalyzed Transformation of a 1,2-Disubstituted Vicinal Diol and the Corresponding Diketone by Wild Type and Laboratory Evolved Alcohol Dehydrogenases Ladda ner fulltext (pdf) av Stereo- and Regioselectivity in Catalyzed Transformation of a 1,2-Disubstituted Vicinal Diol and the Corresponding Diketone by Wild Type and Laboratory Evolved Alcohol Dehydrogenases

Structural and Mutagenesis Studies of the Thiamine-Dependent, Ketone-Accepting YerE from Pseudomonas protegens

Hampel, Sabrina; Steitz, Jan-Patrick; Baierl, Anna; Lehwald, Patrizia et al.

Ingår i ChemBioChem (Print), s. 2283-2292, 2018.

DOI för Structural and Mutagenesis Studies of the Thiamine-Dependent, Ketone-Accepting YerE from Pseudomonas protegens

Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage

Ge, Changrong P; Tong, Dongmei R; Liang, Bibo T; Lönnblom, Erik S et al.

Ingår i JCI INSIGHT, 2017.

DOI för Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage

Dihydropyrimidinase deficiency in four East Asian patients due to novel and rare DPYS mutations affecting protein structural integrity and catalytic activity

Nakajima, Yoko; Meijer, Judith; Dobritzsch, Doreen; Ito, Tetsuya et al.

Ingår i Molecular Genetics and Metabolism, s. 216-222, 2017.

DOI för Dihydropyrimidinase deficiency in four East Asian patients due to novel and rare DPYS mutations affecting protein structural integrity and catalytic activity

Novel PRPS1 gain-of-function mutation in a patient with congenital hyperuricemia and facial anomalies

Porrmann, Joseph; Betcheva-Krajcir, Elitza; Di Donato, Nataliya; Kahlert, Anne-Karin et al.

Ingår i American Journal of Medical Genetics. Part A, s. 2736-2742, 2017.

DOI för Novel PRPS1 gain-of-function mutation in a patient with congenital hyperuricemia and facial anomalies

Relaxation of Nonproductive Binding and Increased Rate of Coenzyme Release in an Alcohol Dehydrogenase Increases Turnover With a Non-Preferred Alcohol Enantiomer

Hamnevik, Emil; Enugala, Thilak Reddy; Maurer, Dirk; Ntuku, Siphosethu et al.

Ingår i The FEBS Journal, s. 3895-3914, 2017.

DOI för Relaxation of Nonproductive Binding and Increased Rate of Coenzyme Release in an Alcohol Dehydrogenase Increases Turnover With a Non-Preferred Alcohol Enantiomer Ladda ner fulltext (pdf) av Relaxation of Nonproductive Binding and Increased Rate of Coenzyme Release in an Alcohol Dehydrogenase Increases Turnover With a Non-Preferred Alcohol Enantiomer

Severe fluoropyrimidine toxicity due to novel and rare DPYD missense mutations, deletion and genomic amplification affecting DPD activity and mRNA splicing

van Kuilenburg, André B P; Meijer, Judith; Maurer, Dirk; Dobritzsch, Doreen et al.

Ingår i Biochimica et Biophysica Acta, s. 721-730, 2017.

DOI för Severe fluoropyrimidine toxicity due to novel and rare DPYD missense mutations, deletion and genomic amplification affecting DPD activity and mRNA splicing

Altered Pre-mRNA Splicing Caused by a Novel Intronic Mutation c.1443+5G>A in the Dihydropyrimidinase (DPYS) Gene.

Nakajima, Yoko; Meijer, Judith; Zhang, Chunhua; Wang, Xu et al.

Ingår i International Journal of Molecular Sciences, 2016.

DOI för Altered Pre-mRNA Splicing Caused by a Novel Intronic Mutation c.1443+5G>A in the Dihydropyrimidinase (DPYS) Gene. Ladda ner fulltext (pdf) av Altered Pre-mRNA Splicing Caused by a Novel Intronic Mutation c.1443+5G>A in the Dihydropyrimidinase (DPYS) Gene.

Conformational Diversity and Enantioconvergence in Potato Epoxide Hydrolase 1

Bauer, Paul; Janfalk Carlsson, Åsa; Amrein, Beat A.; Dobritzsch, Doreen et al.

Ingår i Organic and biomolecular chemistry, s. 5639-5651, 2016.

DOI för Conformational Diversity and Enantioconvergence in Potato Epoxide Hydrolase 1 Ladda ner fulltext (pdf) av Conformational Diversity and Enantioconvergence in Potato Epoxide Hydrolase 1

How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets.

Doak, Bradley C; Zheng, Jie; Dobritzsch, Doreen; Kihlberg, Jan

Ingår i Journal of Medicinal Chemistry, s. 2312-2327, 2016.

DOI för How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets.

Laboratory evolved enzymes provide snapshots of the development of enantioconvergence in enzyme-catalyzed epoxide hydrolysis

Janfalk Carlsson, Åsa; Bauer, Paul; Dobritzsch, Doreeen; Nilsson, Mikael et al.

Ingår i ChemBioChem (Print), s. 1693-1697, 2016.

DOI för Laboratory evolved enzymes provide snapshots of the development of enantioconvergence in enzyme-catalyzed epoxide hydrolysis Ladda ner fulltext (pdf) av Laboratory evolved enzymes provide snapshots of the development of enantioconvergence in enzyme-catalyzed epoxide hydrolysis

Phenotypic and clinical implications of variants in the dihydropyrimidine dehydrogenase gene.

Kuilenburg, André B P van; Meijer, Judith; Tanck, Michael W T; Dobritzsch, Doreen et al.

Ingår i Biochimica et Biophysica Acta, s. 754-762, 2016.

DOI för Phenotypic and clinical implications of variants in the dihydropyrimidine dehydrogenase gene.

Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes

Lindgren, Cecilia; Andersson, Ida E.; Berg, Lotta; Dobritzsch, Doreen et al.

Ingår i Organic and biomolecular chemistry, s. 6203-6216, 2015.

DOI för Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes Ladda ner fulltext (pdf) av Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes

Positional Identification of RT1-B (HLA-DQ) as Susceptibility Locus for Autoimmune Arthritis

Haag, Sabrina; Tuncel, Jonatan; Thordardottir, Soley; Mason, Daniel E. et al.

Ingår i Journal of Immunology, s. 2539-2550, 2015.

DOI för Positional Identification of RT1-B (HLA-DQ) as Susceptibility Locus for Autoimmune Arthritis

Clinical, biochemical and molecular analysis of 13 Japanese patients with beta-ureidopropionase deficiency demonstrates high prevalence of the c.977G > A (p.R326Q) mutation

Nakajima, Yoko; Meijer, Judith; Dobritzsch, Doreen; Ito, Tetsuya et al.

Ingår i Journal of Inherited Metabolic Disease, s. 801-812, 2014.

DOI för Clinical, biochemical and molecular analysis of 13 Japanese patients with beta-ureidopropionase deficiency demonstrates high prevalence of the c.977G > A (p.R326Q) mutation Ladda ner fulltext (pdf) av Clinical, biochemical and molecular analysis of 13 Japanese patients with beta-ureidopropionase deficiency demonstrates high prevalence of the c.977G > A (p.R326Q) mutation

Epitope-specific antibody response is controlled by immunoglobuline V_H polymorphisms

Raposo, Bruno; Dobritzsch, Doreen; Ge, Changrong; Ekman, Diana et al.

Ingår i Journal of Experimental Medicine, s. 405-411, 2014.

DOI för Epitope-specific antibody response is controlled by immunoglobuline V_H polymorphisms

Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme

Dobritzsch, Doreen; Wang, Huaming; Schneider, Gunter; Yu, Shukun

Ingår i Biochemical Journal, s. 441-452, 2014.

DOI för Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme

Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin in Streptomyces nogalater

Claesson, Magnus; Siitonen, Vilja; Dobritzsch, Doreen; Metsä-Ketelä, Mikko et al.

Ingår i The FEBS Journal, s. 3251-3263, 2012.

DOI för Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin in Streptomyces nogalater

ß-ureidopropionase deficiency: phenotype, genotype and protein structural consequences in 16 patients

van Kuilenburg, André B P; Dobritzsch, Doreen; Meijer, Judith; Krumpel, Michael et al.

Ingår i Biochimica et Biophysica Acta, s. 1096-108, 2012.

DOI för ß-ureidopropionase deficiency: phenotype, genotype and protein structural consequences in 16 patients

Crystal structure of an arthritogenic anticollagen immune complex

Dobritzsch, Doreen; Lindh, Ingrid; Uysal, Hüseyin; Nandakumar, Kutty S et al.

Ingår i Arthritis and Rheumatism, s. 3740-3748, 2011.

DOI för Crystal structure of an arthritogenic anticollagen immune complex

Dihydropyrimidinase deficiency: Phenotype, genotype and structural consequences in 17 patients

van Kuilenburg, André B P; Dobritzsch, Doreen; Meijer, Judith; Meinsma, Rutger et al.

Ingår i Biochimica et Biophysica Acta - Molecular Basis of Disease, s. 639-648, 2010.

DOI för Dihydropyrimidinase deficiency: Phenotype, genotype and structural consequences in 17 patients

Insights into the mechanism of dihydropyrimidine dehydrogenase from site-directed mutagenesis targeting the active site loop and redox cofactor coordination

Lohkamp, Bernhard; Voevodskaya, Nina; Lindqvist, Ylva; Dobritzsch, Doreen

Ingår i Biochimica et Biophysica Acta, s. 2198-2206, 2010.

DOI för Insights into the mechanism of dihydropyrimidine dehydrogenase from site-directed mutagenesis targeting the active site loop and redox cofactor coordination

Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity

van Kuilenburg, André B P; Meijer, Judith; Mul, Adri N P M; Meinsma, Rutger et al.

Ingår i Human Genetics, s. 529-538, 2010.

DOI för Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity

A mixture of fortunes: the curious determination of the structure of Escherichia coli BL21 Gab protein

Lohkamp, Bernhard; Dobritzsch, Doreen

Ingår i Acta Crystallographica Section D, s. 407-415, 2008.

DOI för A mixture of fortunes: the curious determination of the structure of Escherichia coli BL21 Gab protein

A recruited protease is involved in catabolism of pyrimidines

Andersen, Birgit; Lundgren, Stina; Dobritzsch, Doreen; Piskur, Jure

Ingår i Journal of Molecular Biology, s. 243-250, 2008.

DOI för A recruited protease is involved in catabolism of pyrimidines

Amidohydrolases of the reductive pyrimidine catabolic pathway: purification, characterization, structure, reaction mechanisms and enzyme deficiency

Schnackerz, Klaus D; Dobritzsch, Doreen

Ingår i Biochimica et Biophysica Acta, s. 431-444, 2008.

DOI för Amidohydrolases of the reductive pyrimidine catabolic pathway: purification, characterization, structure, reaction mechanisms and enzyme deficiency

Degradation of pyrimidines in Saccharomyces kluyveri: transamination of beta-alanine

Schnackerz, K D; Andersen, G; Dobritzsch, Doreen; Piskur, J

Ingår i Nucleosides, Nucleotides & Nucleic Acids, s. 794-799, 2008.

DOI för Degradation of pyrimidines in Saccharomyces kluyveri: transamination of beta-alanine

Identification of two novel mutations C79X and R235Q in the dihydropyrimidine dehydrogenase gene in a patient presenting with hematuria

van Kuilenburg, A B P; Meijer, J; Dobritzsch, Doreen; Lohkamp, B et al.

Ingår i Nucleosides, Nucleotides & Nucleic Acids, s. 809-815, 2008.

DOI för Identification of two novel mutations C79X and R235Q in the dihydropyrimidine dehydrogenase gene in a patient presenting with hematuria

Saccharomyces kluyveri as a model organism to study pyrimidine degradation

Beck, Halfdan; Dobritzsch, Doreen; Piskur, Jure

Ingår i FEMS yeast research (Print), s. 1209-1213, 2008.

DOI för Saccharomyces kluyveri as a model organism to study pyrimidine degradation

The crystal structure of beta-alanine synthase from Drosophila melanogaster reveals a homooctameric helical turn-like assembly

Lundgren, Stina; Lohkamp, Bernhard; Andersen, Birgit; Piskur, Jure et al.

Ingår i Journal of Molecular Biology, s. 1544-1559, 2008.

DOI för The crystal structure of beta-alanine synthase from Drosophila melanogaster reveals a homooctameric helical turn-like assembly

A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast

Andersen, Gorm; Andersen, Birgit; Dobritzsch, Doreen; Schnackerz, Klaus D et al.

Ingår i The FEBS Journal, s. 1804-1017, 2007.

DOI för A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast

Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency

van Kuilenburg, André B P; Meijer, Judith; Dobritzsch, Doreen; Meinsma, Rutger et al.

Ingår i Molecular Genetics and Metabolism, s. 157-164, 2007.

DOI för Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency

Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis

Koskiniemi, Hanna; Metsä-Ketelä, Mikko; Dobritzsch, Doreen; Kallio, Pauli et al.

Ingår i Journal of Molecular Biology, s. 633-648, 2007.

DOI för Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis

Crystal structures of yeast beta-alanine synthase complexes reveal the mode of substrate binding and large scale domain closure movements

Lundgren, Stina; Andersen, Birgit; Piskur, Jure; Dobritzsch, Doreen

Ingår i Journal of Biological Chemistry, s. 36037-36047, 2007.

DOI för Crystal structures of yeast beta-alanine synthase complexes reveal the mode of substrate binding and large scale domain closure movements

Crystallization and preliminary X-ray data analysis of beta-alanine synthase from Drosophila melanogaster

Lundgren, Stina; Andersen, Birgit; Piskur, Jure; Dobritzsch, Doreen

Ingår i Acta Crystallographica. Section F, s. 874-877, 2007.

DOI för Crystallization and preliminary X-ray data analysis of beta-alanine synthase from Drosophila melanogaster

Catabolism of pyrimidines in yeast: a tool to understand degradation of anticancer drugs

Andersen, G; Merico, A; Björnberg, O; Andersen, B et al.

Ingår i Nucleosides, Nucleotides & Nucleic Acids, s. 991-996, 2006.

DOI för Catabolism of pyrimidines in yeast: a tool to understand degradation of anticancer drugs

Purification, crystallization and X-ray diffraction analysis of dihydropyrimidinase from Dictyostelium discoideum

Lohkamp, Bernhard; Andersen, Birgit; Piskur, Jure; Dobritzsch, Doreen

Ingår i Acta Crystallographica. Section F, s. 36-38, 2006.

DOI för Purification, crystallization and X-ray diffraction analysis of dihydropyrimidinase from Dictyostelium discoideum

The crystal structures of dihydropyrimidinases reaffirm the close relationship between cyclic amidohydrolases and explain their substrate specificity

Lohkamp, Bernhard; Andersen, Birgit; Piskur, Jure; Dobritzsch, Doreen

Ingår i Journal of Biological Chemistry, s. 13762-13776, 2006.

DOI för The crystal structures of dihydropyrimidinases reaffirm the close relationship between cyclic amidohydrolases and explain their substrate specificity

Crystallization and X-ray diffraction analysis of dihydropyrimidinase from Saccharomyces kluyveri

Dobritzsch, Doreen; Andersen, Birgit; Piskur, Jure

Ingår i Acta Crystallographica. Section F, s. 359-362, 2005.

DOI för Crystallization and X-ray diffraction analysis of dihydropyrimidinase from Saccharomyces kluyveri

Identification of three novel mutations in the dihydropyrimidine dehydrogenase gene associated with altered pre-mRNA splicing or protein function

Van Kuilenburg, André B P; Meinsma, Rutger; Beke, Eva; Bobba, Barbara et al.

Ingår i Biological chemistry (Print), s. 319-324, 2005.

DOI för Identification of three novel mutations in the dihydropyrimidine dehydrogenase gene associated with altered pre-mRNA splicing or protein function

Dihydropyrimidine dehydrogenase: a flavoprotein with four iron-sulfur clusters

Schnackerz, Klaus D; Dobritzsch, Doreen; Lindqvist, Ylva; Cook, Paul F

Ingår i Biochimica et Biophysica Acta, s. 61-74, 2004.

DOI för Dihydropyrimidine dehydrogenase: a flavoprotein with four iron-sulfur clusters

Crystallization and preliminary X-ray analysis of beta-alanine synthase from the yeast Saccharomyces kluyveri

Dobritzsch, Doreen; Gojković, Zoran; Andersen, Birgit; Piskur, Jure

Ingår i Acta Crystallographica Section D, s. 1267-1269, 2003.

DOI för Crystallization and preliminary X-ray analysis of beta-alanine synthase from the yeast Saccharomyces kluyveri

Yeast beta-alanine synthase shares a structural scaffold and origin with dizinc-dependent exopeptidases

Lundgren, Stina; Gojković, Zoran; Piskur, Jure; Dobritzsch, Doreen

Ingår i Journal of Biological Chemistry, s. 51851-51862, 2003.

DOI för Yeast beta-alanine synthase shares a structural scaffold and origin with dizinc-dependent exopeptidases

Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil: Implications for mechanism of inhibition and electron transfer

Dobritzsch, Doreen; Ricagno, Stefano; Schneider, Gunter; Schnackerz, Klaus D et al.

Ingår i Journal of Biological Chemistry, s. 13155-13166, 2002.

DOI för Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil: Implications for mechanism of inhibition and electron transfer

Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure

van Kuilenburg, André B P; Dobritzsch, Doreen; Meinsma, Rutger; Haasjes, Janet et al.

Ingår i Biochemical Journal, s. 157-163, 2002.

Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti-cancer drug 5-fluorouracil

Dobritzsch, Doreen; Schneider, G; Schnackerz, K D; Lindqvist, Y

Ingår i EMBO Journal, s. 650-660, 2001.

DOI för Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti-cancer drug 5-fluorouracil

Crystallization and preliminary X-ray study of pig liver dihydropyrimidine dehydrogenase

Dobritzsch, Doreen; Persson, K; Schneider, G; Lindqvist, Y

Ingår i Acta Crystallographica Section D, s. 153-155, 2001.

DOI för Crystallization and preliminary X-ray study of pig liver dihydropyrimidine dehydrogenase

The structural basis of substrate activation in yeast pyruvate decarboxylase: A crystallographic and kinetic study

Lu, G; Dobritzsch, Doreen; Baumann, S; Schneider, G et al.

Ingår i European Journal of Biochemistry, s. 861-868, 2000.

DOI för The structural basis of substrate activation in yeast pyruvate decarboxylase: A crystallographic and kinetic study

High resolution crystal structure of pyruvate decarboxylase from Zymomonas mobilis: Implications for substrate activation in pyruvate decarboxylases

Dobritzsch, Doreen; König, S; Schneider, G; Lu, G

Ingår i Journal of Biological Chemistry, s. 20196-20204, 1998.

DOI för High resolution crystal structure of pyruvate decarboxylase from Zymomonas mobilis: Implications for substrate activation in pyruvate decarboxylases

Novel tetramer assembly of pyruvate decarboxylase from brewer's yeast observed in a new crystal form

Lu, G; Dobritzsch, Doreen; König, S; Schneider, G

Ingår i FEBS Letters, s. 249-253, 1997.

DOI för Novel tetramer assembly of pyruvate decarboxylase from brewer's yeast observed in a new crystal form