People in Varghese Group
Welcome to the Varghese Group!
Below you will find information about us in the group, with links to our contact information, etc.
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The focus of my research is to realize the transformative power of Chemistry at the interface between Cell and Molecular Biology and Medicine. Our research interests are in the interdisciplinary fields that combine synthetic organic chemistry with biomolecular chemistry and medicine. Specifically, we develop functional biomaterials for regenerative medicine application and design oligonucleotide drugs and targeted delivery formulations for tissue regeneration and anticancer therapy.
Nithiyanandan Krishnan completed his PhD at the Indian Institute of Science, Education and Research (IISER) Tiruvananthapuram in 2019. He joined Varghese lab as a Marie-Curie postdoctoral research fellow in 2021. His project includes synthesis and delivery of chemically modified functional nucleic acids to improve the RNA interference therapy.
Partha completed his Ph.D. at the Indian Institute of Technology Kharagpur (IIT KGP), India in Chemistry. He later pursued his postdoctoral study at SIPBS, University of Strathclyde, UK, and School of Medicine, University of Texas RGV, USA. He joined Varghese’s lab as a postdoctoral research fellow in 2022. His project includes the synthesis of multimodal delivery systems and imaging of intracellular transport of chemically modified functional nucleic acids to improve RNA interference therapy. Additionally, he initiates the following projects-(i) the use of high-throughput techniques to improve RNAi therapy and (ii) in vitro polymerization technique.
Mahsa completed her bachelor’s in Mechanical engineering at Yazd University, Iran, and continued to pursue a master’s degree in Biomedical Engineering at the Amirkabir University of Technology. Then, she started her Ph.D. in Tissue engineering at the National Institute of Genetic Engineering and Biotechnology (NIGEB). During her Ph.D., Mahsa joined the Khademhosseini lab at Harvard-MIT Health Science and Technology, USA. Afterward, she came to Macromolecular Chemistry at Uppsala University, to Samanta’s group, and joined the Varghese Group in September 2022. Her project involves biomaterials and nucleic acid research, specifically in cell bioengineering, 3D matrix development, and in vivo studies.
Christos completed his Bachelor’s degree in Mechanical Engineering at the Technological Educational Institute (TEI) of Central Macedonia in Serres, Greece. He later pursued his Master's in Engineering Physics at the Royal Institute of Technology (KTH) in Stockholm, Sweden. Currently, he is working with ECM-based biomaterials for tissue regeneration and his interests include polymer physics and chemistry, mechanics, thermodynamics, CAD/CAM, and 3D bioprinting.
Rohith Pavan Parvathaneni
Rohith Pavan Parvathaneni was born on 23 April 1997, in Andhra Pradesh, India. In 2018, he finished his B.Tech. in Chemical Science and Technology at the Indian Institute of Technology Guwahati (IITG). He has a Master's in Applied Chemistry with a specialization in Medicinal Chemistry at the Technical University of Denmark (DTU). Rohith joined Varghese Group in March 2021. He is working on the synthesis and delivery of chemically modified nucleic acids to improve RNA interference therapy.
Shima finished her Bachelor’s in Materials Engineering at the Isfahan University of Technology, Iran, and started a master’s program in Materials Engineering-Identification and Selection of Materials at the Isfahan University of Technology. Her master thesis focused on Nanocomposite hydrogels for tissue engineering and wound healing applications. Shima joined Varghese Group in June 2021 as a Marie Curie PhD student. Her project involves development of crosslinking chemistry to prepare extracellular matrix (ECM) mimetic hydrogel materials for cartilage regeneration and in situ visualization of ECM.
Hamid completed his Bachelor’s degree in Materials Engineering at Isfahan University of Technology (IUT), Iran. He continued his education at IUT and pursued his Master's in Materials Engineering (Identification and Selection of Materials). During his M.Sc. he was working on development of an injectable hydrogel for promoting cell growth. Hamid joined Varghese Group in June 2022 as a Ph.D. student. Currently, he is working on a project involving synthetic organic chemistry to develop chemically-modified oligonucleotide drugs and to develop extracellular matrix mimetic 3D hydrogels scaffold.
Chemical modifications of nucleic acids to improve their therapeutic efficiency and stability.
Anti-inflammatory hydrogels for Osteoarthritis.
3D printing of osteoinductive bone scaffolds.