Varghese Group: Translational Chemical Biology Laboratory

An image that illustrates the interface between organic chemistry, cell and molecular biology and medicine.

The focus of our research is to realize the transformative power of Chemistry at the interface between Cell and Molecular Biology and Medicine. Our research interests are in the interdisciplinary fields of biomolecular chemistry, with a focus on the chemistry and biochemistry of nucleic acids and natural biomolecules.

We use techniques and concepts from chemical biology, organic chemistry, biochemistry, cell and molecular biology, and other disciplines to design our experiments and interpret our results. Our ambition is to utilize synthetic organic chemistry to fabricate new materials and therapeutic nucleic acids to transform medicine that could be translated in an animal model and perhaps for clinical application.

Research interests

Our core research interest is in organic chemistry, chemical biology, biomaterials, synthetic biology, regenerative medicine, and anticancer therapeutics.

You can find more information about our research areas at our ongoing research page.

Available positions: Two Ph.Ds

There are two Ph.D. positions open in my group that is a part of an international collaborative project funded by the European Union within the Marie Curie training network Carthago. These projects are related to nucleic acid therapeutics and biomaterials research for regenerative medicine applications.  Candidates with strong motivation for research with experience in working on related projects at well-established laboratories are encouraged to apply.

Position 1. Design, synthesis and delivery of chemically modified oligonucleotides

Position 2. Hydrogels and Near-Infrared Probes

Read more about the positions and their requirements in this document (click the link)