Kemiska sektionen

Publikationer

  • Kjellander, Marcus; Billinger, Erika; Ramachandraiah, Harisha; Boman, Mats et al.

    A flow-through nanoporous alumina trypsin bioreactor for mass spectrometry peptide fingerprinting

    Ingår i Journal of Proteomics, s. 165-172, 2018.

  • Hamnevik, Emil; Maurer, Dirk; Enugala, Thilak Reddy; Chu, Thao et al.

    Directed Evolution of Alcohol Dehydrogenase for Improved Stereoselective Redox Transformations of 1-Phenylethane-1,2-Diol and Its Corresponding Acyloin

    Ingår i Biochemistry, s. 1059-1062, 2018.

  • Janfalk Carlsson, Åsa; Bauer, Paul; Dobritzsch, Doreen; Kamerlin, Shina C Lynn et al.

    Epoxide Hydrolysis as a Model System for Understanding Flux Through a Branched Reaction Scheme

    Ingår i IUCrJ, s. 269-282, 2018.

  • Gabelica, Valérie; Marklund, Erik

    Fundamentals of ion mobility spectrometry

    Ingår i Current opinion in chemical biology, s. 51-59, 2018.

  • Costeira-Paulo, Joana; Gault, Joseph; Popova, Gergana; Ladds, Marcus J G W et al.

    Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase

    Ingår i Cell Chemical Biology, 2018.

  • Young, Gavin; Hundt, Nikolas; Cole, Daniel; Fineberg, Adam et al.

    Quantitative mass imaging of single biological macromolecules

    Ingår i Science, s. 423-427, 2018.

  • Marklund, Erik G.; Zhang, Yichen; Basha, Eman; Benesch, Justin L P et al.

    Structural and functional aspects of the interaction partners of the small heat-shock protein in Synechocystis

    Ingår i Cell stress & chaperones (Print), 2018.

  • Hochberg, Georg K A; Shepherd, Dale A; Marklund, Erik G.; Santhanagoplan, Indu et al.

    Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions.

    Ingår i Science, s. 930-935, 2018.

  • B41, Husargatan 3, Uppsala, Sweden 2018-04-06 kl 09:30

    Maurer, Dirk

    Structure Function Relationships in Pyrimidine Degrading and Biocatalytic Enzymes, and Their Implications for Cancer Therapy and Green Chemistry

  • Al-Smadi, Derar; Enugala, Thilak Reddy; Norberg, Thomas; Kihlberg, Jan et al.

    Synthesis of substrates for aldolase-catalyzed reactions - A comparison of methods for the synthesis of substituted phenylacetaldehydes

    Ingår i Synlett, s. 1187-1190, 2018.

  • Sundell, Gustav; Vögeli, Beat; Ivarsson, Ylva; Chi, Celestine N. et al.

    The Sign of Nuclear Magnetic Resonance Chemical Shift Difference as a Determinant of the Origin of Binding Selectivity: Elucidation of the Position Dependence of Phosphorylation in Ligands Binding to Scribble PDZ1

    Ingår i Biochemistry, s. 66-71, 2018.

  • Lion, Shamiran

    To discover and validate host response biomarkers for Mycobacterium tuberculosis testing on the GeneXpert platform

    Ingår i Biochemistry, 2018.

  • Ge, Changrong P; Tong, Dongmei R; Liang, Bibo T; Lönnblom, Erik S et al.

    Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage

    Ingår i JCI INSIGHT, 2017.

  • Abdurakhmanov, Eldar; Solbak, Sara Oie; Danielson, U. Helena

    Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase

    Ingår i Viruses, 2017.

  • BMC A1:111A, Husargatan 3, Uppsala 2017-05-19 kl 09:15

    Hamnevik, Emil

    Characterization and Directed Evolution of an Alcohol Dehydrogenase: A Study Towards Understanding of Three Central Aspects of Substrate Selectivity

  • Solbak, Sara M.Ø.; Abdurakhmanov, Eldar; Vedeler, Anni; Danielson, U. Helena et al.

    Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition

    Ingår i Virology Journal, 2017.

  • A1:111 BMC, Husargatan 3, Uppsala 2017-09-13 kl 09:00

    Bauer, Paul

    Computational modelling of enzyme selectivity

  • Marklund, Erik; Ekeberg, Tomas; Moog, Mathieu; Benesch, Justin L. P. et al.

    Controlling Protein Orientation in Vacuum Using Electric Fields

    Ingår i Journal of Physical Chemistry Letters, s. 4540-4544, 2017.

  • Saupe, Falk; Reichel, Matthias; Huijbers, Elisabeth J. M.; Femel, Julia et al.

    Development of a novel therapeutic vaccine carrier that sustains high antibody titers against several targets simultaneously

    Ingår i The FASEB Journal, s. 1204-1214, 2017.

  • Nakajima, Yoko; Meijer, Judith; Dobritzsch, Doreen; Ito, Tetsuya et al.

    Dihydropyrimidinase deficiency in four East Asian patients due to novel and rare DPYS mutations affecting protein structural integrity and catalytic activity

    Ingår i Molecular Genetics and Metabolism, s. 216-222, 2017.

  • Davey, Norman E.; Seo, Moon-Hyeong; Yadav, Vikash Kumar; Jeon, Jouhyun et al.

    Discovery of short linear motif-mediated interactions through phage display of intrinsically disordered regions of the human proteome

    Ingår i The FEBS Journal, s. 485-498, 2017.

  • Landreh, Michael; Costeira-Paulo, Joana; Gault, Joseph; Marklund, Erik et al.

    Effects of Detergent Micelles on Lipid Binding to Proteins in Electrospray Ionization Mass Spectrometry

    Ingår i Analytical Chemistry, s. 7425-7430, 2017.

  • Wang, Huan; Huang, Xiao; Strømme, Maria; Sjödin, Martin et al.

    Electrochemical performance of Terephthalate-Functionalized Poly(3,4-ethylenedioxythiophene) conducting redox polymer

    Ingår i Analytical Chemistry, 2017.

  • Hultqvist, Greta; Åberg, Emma; Camilloni, Carlo; Sundell, Gustav et al.

    Emergence and evolution of an interaction between intrinsically disordered proteins

    Ingår i eLIFE, 2017.

  • Hillier, Heidi Therese

    How is substrate selectivity in hydride transfer decided in an alcohol dehydrogenase?: Directed evolution of alcohol dehydrogenase A from Rhodococcus ruber DSM 44541 through iterative saturation mutagenesis, a study to understand the structure and function relationship of enzymatic catalysis

    Ingår i eLIFE, 2017.

  • Nosrati, Masoumeh; Solbak, Sara; Nordesjö, Olle; Nissbeck, Mikael et al.

    Insights from engineering the Affibody-Fc interaction with a computational-experimental method

    Ingår i Protein Engineering Design & Selection, s. 593-601, 2017.

  • Landreh, Michael; Marklund, Erik G; Uzdavinys, Povilas; Degiacomi, Matteo T. et al.

    Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters

    Ingår i Nature Communications, 2017.

  • Linkuviene, V.; Talibov, Vladimir O; Danielson, U. Helena; Matulis, D. et al.

    Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction

    Ingår i European Biophysics Journal, s. S91-S91, 2017.

  • Landreh, Michael; Andersson, Marlene; Marklund, Erik G.; Jia, Qiupin et al.

    Mass spectrometry captures structural intermediates in protein fiber self-assembly

    Ingår i Chemical Communications, s. 3319-3322, 2017.

  • Porrmann, Joseph; Betcheva-Krajcir, Elitza; Di Donato, Nataliya; Kahlert, Anne-Karin et al.

    Novel PRPS1 gain-of-function mutation in a patient with congenital hyperuricemia and facial anomalies

    Ingår i American Journal of Medical Genetics. Part A, s. 2736-2742, 2017.

  • Wu, Cheng-Guo; Chen, Hui; Guo, Feng; Yadav, Vikash K et al.

    PP2A-B' holoenzyme substrate recognition, regulation and role in cytokinesis

    Ingår i Cell Discovery, 2017.

  • Hamnevik, Emil; Enugala, Thilak Reddy; Maurer, Dirk; Ntuku, Siphosethu et al.

    Relaxation of Nonproductive Binding and Increased Rate of Coenzyme Release in an Alcohol Dehydrogenase Increases Turnover With a Non-Preferred Alcohol Enantiomer

    Ingår i The FEBS Journal, s. 3895-3914, 2017.

  • van Kuilenburg, André B P; Meijer, Judith; Maurer, Dirk; Dobritzsch, Doreen et al.

    Severe fluoropyrimidine toxicity due to novel and rare DPYD missense mutations, deletion and genomic amplification affecting DPD activity and mRNA splicing

    Ingår i Biochimica et Biophysica Acta, s. 721-730, 2017.

  • Wigington, Callie P.; Roy, Jagoree; Damle, Nikhil P.; El Cho, Shein et al.

    Uncovering Novel Substrates and Functions for the Calcineurin Phosphatase in Human Cells

    Ingår i The FASEB Journal, 2017.

  • Erik, Gioeli

    Utbytesoptimering inom läkemedelsproduktion: Identifiering av kassationsorsaker inom AstraZenecas packningsprocess i Gärtuna

    Ingår i The FASEB Journal, 2017.

  • Renaud, Jean-Paul; Chung, Chun-wa; Danielson, U. Helena; Egner, Ursula et al.

    Biophysics in drug discovery: impact, challenges and opportunities

    Ingår i Nature reviews. Drug discovery, s. 679-698, 2016.

  • Bauer, Paul; Janfalk Carlsson, Åsa; Amrein, Beat A.; Dobritzsch, Doreen et al.

    Conformational Diversity and Enantioconvergence in Potato Epoxide Hydrolase 1

    Ingår i Organic and biomolecular chemistry, s. 5639-5651, 2016.

  • Belfrage, Anna Karin; Abdurakhmanov, Eldar; Åkerblom, Eva; Brandt, Peter et al.

    Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease

    Ingår i Bioorganic & Medicinal Chemistry, s. 2603-2620, 2016.

  • Egea-Jimenez, Antonio Luis; Gallardo, Rodrigo; Garcia-Pino, Abel; Ivarsson, Ylva et al.

    Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling

    Ingår i Nature Communications, 2016.

  • Karlsson, O Andreas; Sundell, Gustav N; Andersson, Eva; Ivarsson, Ylva et al.

    Improved affinity at the cost of decreased specificity: a recurring theme in PDZ-peptide interactions.

    Ingår i Scientific Reports, 2016.

  • Talibov, Vladimir O; Linkuvienė, Vaida; Matulis, Daumantas; Danielson, Helena U. et al.

    Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII

    Ingår i Journal of Medicinal Chemistry, s. 2083-2093, 2016.

  • Janfalk Carlsson, Åsa; Bauer, Paul; Dobritzsch, Doreeen; Nilsson, Mikael et al.

    Laboratory evolved enzymes provide snapshots of the development of enantioconvergence in enzyme-catalyzed epoxide hydrolysis

    Ingår i ChemBioChem (Print), s. 1693-1697, 2016.

  • Raykova, Doroteya; Koos, Bjoern; Asplund, Anna; Gelleri, Marton et al.

    Let There Be Light!

    Ingår i Proteomes, 2016.

  • Ma, Huan; Szeler, Klaudia; Kamerlin, Shina Caroline Lynn; Widersten, Mikael et al.

    Linking coupled motions and entropic effects to the catalytic activity of 2-deoxyribose-5-phosphate aldolase (DERA)

    Ingår i Chemical Science, s. 1415-1421, 2016.

  • Nim, Satra; Jeon, Jouhyun; Corbi-Verge, Carles; Seo, Moon-Hyeong et al.

    Pooled screening for antiproliferative inhibitors of protein-protein interactions.

    Ingår i Nature Chemical Biology, s. 275-281, 2016.

  • Garrido-Urbani, Sarah; Garg, Pankaj; Ghossoub, Rania; Arnold, Roland et al.

    Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin

    Ingår i FEBS Letters, s. 3-12, 2016.

  • Wigington, C. P.; Damle, N. P.; Roy, J.; Cho, S. E. et al.

    Uncovering novel substrates and functions for the calcineurin phosphatase in human cells.

    Ingår i Molecular Biology of the Cell, 2016.

  • Ma, Huan; Enugala, Thilak Reddy; Widersten, Mikael

    A micro-plate format assay for real-time screening for new aldolases accepting aryl-substituted acceptor substrates

    Ingår i ChemBioChem (Print), s. 2595-2598, 2015.

  • B22, BMC, Husargatan3, Uppsala 2016-02-05 kl 13:15

    Ma, Huan

    Aldolases for Enzymatic Carboligation: Directed Evolution and Enzyme Structure-Function Relationship Studies

  • Karlsson, O. Andreas; Ramirez, Juan; Öberg, Daniel; Malmqvist, Tony et al.

    Design of a PDZbody, a bivalent binder of the E6 protein from human papillomavirus

    Ingår i Scientific Reports, 2015.

  • Dahlström, Kathe M.; Blikstad, Cecilia; Widersten, Mikael; Salminen, Tiina A. et al.

    Directed evolution on FucO - structural explanations for changes in substrate scope

    Ingår i Protein Science, s. 199-200, 2015.

  • B21, BMC, Husargatan 3, Uppsala 2015-12-18 kl 09:00

    Abdurakhmanov, Eldar

    Discovery and evaluation of direct acting antivirals against hepatitis C virus

  • Zhang, Wei; Dourado, Daniel F. A. R.; Mannervik, Bengt

    Evolution of the active site of human glutathione transferase A2-2 for enhanced activity with dietary isothiocyanates

    Ingår i Biochimica et Biophysica Acta - General Subjects, s. 742-749, 2015.

  • Amrein, Beat A.; Bauer, Paul; Duarte, Fernanda; Janfalk Carlsson, Åsa et al.

    Expanding the catalytic triad in epoxide hydrolases and related enzymes

    Ingår i ACS Catalysis, s. 5702-5713, 2015.

  • Blikstad, Cecilia; Ivarsson, Ylva

    High-throughput methods for identification of protein-protein interactions involving short linear motifs

    Ingår i Cell Communication and Signaling, 2015.

  • Lindgren, Cecilia; Andersson, Ida E.; Berg, Lotta; Dobritzsch, Doreen et al.

    Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes

    Ingår i Organic and biomolecular chemistry, s. 6203-6216, 2015.

  • Aksoy, N. H.; Mannervik, B.

    Inhibitory effects of ethacrynic acid on glutathione S-transferase A1-1 from Callithrix jacchus

    Ingår i The FEBS Journal, s. 348-348, 2015.

  • Spurny, Radovan; Debaveye, Sarah; Farinha, Ana; Veys, Ken et al.

    Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the alpha 7 nicotinic acetylcholine receptor

    Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. E2543-E2552, 2015.

  • Danielson, U. Helena

    Molecular Interaction Analysis for Discovery of Drugs Targeting Enzymes and for Resolving Biological Function

    Ingår i Multifaceted Roles Of Crystallography In Modern Drug Discovery, s. 223-240, 2015.

  • Tsourma, Maria

    Novel approach to radionuclide therapy of cancer: affibody-based bio-orthogonal chemistry mediated pretargeting

    Ingår i Multifaceted Roles Of Crystallography In Modern Drug Discovery, 2015.

  • Haag, Sabrina; Tuncel, Jonatan; Thordardottir, Soley; Mason, Daniel E. et al.

    Positional Identification of RT1-B (HLA-DQ) as Susceptibility Locus for Autoimmune Arthritis

    Ingår i Journal of Immunology, s. 2539-2550, 2015.

  • Koos, Björn; Cane, Gaëlle; Grannas, Karin; Löf, Liza et al.

    Proximity-dependent initiation of hybridization chain reaction

    Ingår i Nature Communications, 2015.

  • Ganesan, Ashok; Debulpaep, Maja; Wilkinson, Hannah; Van Durme, Joost et al.

    Selectivity of Aggregation-Determining Interactions

    Ingår i Journal of Molecular Biology, s. 236-247, 2015.

  • Ilari, Andrea; Fiorillo, Annarita; Poser, Elena; Lalioti, Vasiliki S. et al.

    Structural basis of Sorcin-mediated calcium-dependent signal transduction

    Ingår i Scientific Reports, 2015.

  • Ilari, Andrea; Fiorillo, Annarita; Poser, Elena; Lalioti, Vasiliki S. et al.

    Structural basis of Sorcin-mediated calcium-dependent signal transduction

    Ingår i Scientific Reports, 2015.

  • Ragnarsson, Ulf; Grehn, Leif; Pehk, Tonis

    An unprecedented rearrangement of a 1,1-diprotected hydrazine derivative. Structure revision of a catalyst-containing by-product

    Ingår i Tetrahedron Letters, s. 7019-7022, 2014.

  • Nakajima, Yoko; Meijer, Judith; Dobritzsch, Doreen; Ito, Tetsuya et al.

    Clinical, biochemical and molecular analysis of 13 Japanese patients with beta-ureidopropionase deficiency demonstrates high prevalence of the c.977G > A (p.R326Q) mutation

    Ingår i Journal of Inherited Metabolic Disease, s. 801-812, 2014.

  • Bauer, Paul

    Directed Evolution of ADH-A from Rhodococcus ruber DSM 44541

    Ingår i Journal of Inherited Metabolic Disease, 2014.

  • Raposo, Bruno; Dobritzsch, Doreen; Ge, Changrong; Ekman, Diana et al.

    Epitope-specific antibody response is controlled by immunoglobuline VH polymorphisms

    Ingår i Journal of Experimental Medicine, s. 405-411, 2014.

  • Laadan, B.; Wallace-Salinas, V.; Janfalk Carlsson, Åsa; Almeida, J. et al.

    Furaldehyde substrate specificity and kinetics of Saccharomyces cerevisiae alcohol dehydrogenase 1 variants

    Ingår i Microbial Cell Factories, s. 112-, 2014.

  • Kjellander, Marcus; Mazari, Aslam M.A.; Boman, Mats; Mannervik, Bengt et al.

    Glutathione transferases immobilized on nanoporous alumina: Flow system kinetics, screening and stability

    Ingår i Analytical Biochemistry, s. 59-63, 2014.

  • Modén, Olof; Mannervik, Bengt

    Glutathione Transferases in the Bioactivation of Azathioprine

    Ingår i REDOX AND CANCER PT A, s. 199-244, 2014.

  • Martin, M.; Anscombe, E.; Meschini, E.; Staunton, D. et al.

    Identification and characterization of an irreversible inhibitor of CDK2

    Ingår i European Journal of Cancer, s. 106-106, 2014.

  • Berglin, Lennart; Kjellander, Marcus; Johansson, Gunnar

    In situ generation of iminodiacetic acid groups on nanoporous alumina for the reversible immobilization of enzymes and other biomolecules

    Ingår i Biotechnology letters, s. 1819-1825, 2014.

  • Sundell, Gustav; Ivarsson, Ylva

    Interaction Analysis through Proteomic Phage Display

    Ingår i BioMed Research International, s. 176172-, 2014.

  • Dourado, Daniel F. A. R.; Fernandes, Pedro Alexandrino; Mannervik, Bengt; Ramos, Maria Joao et al.

    Isomerization of Delta(5)-Androstene-3,17-dione into Delta(4)-Androstene-3, 17-dione Catalyzed by Human Glutathione Transferase A3-3: A Computational Study Identifies a Dual Role for Glutathione

    Ingår i Journal of Physical Chemistry A, s. 5790-5800, 2014.

  • Lampa, Anna; Bergman, Sara; Svahn Gustafsson, Sofia; Alogheli, Hiba et al.

    Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

    Ingår i ACS Medicinal Chemistry Letters, s. 249-254, 2014.

  • B42, BMC, Uppsala Universitet, Husargatan 3, 751 23, Uppsala 2014-02-28 kl 13:15

    Ehrenberg, Angelica

    Novel Procedures for Identification and Characterization of Viral Proteases Inhibitors

  • B42, Husargatan 3, 751 23 Uppsala 2014-05-16 kl 13:15

    Seeger, Christian

    Revealing Secrets of Synaptic Protein Interactions: A Biosensor based Strategy

  • Toresson, Henrik

    Steady state kinetics and regioselectivity for variants of StEH1 hydrolyzing different epoxide substrates

    Ingår i ACS Medicinal Chemistry Letters, 2014.

  • Dobritzsch, Doreen; Wang, Huaming; Schneider, Gunter; Yu, Shukun et al.

    Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme

    Ingår i Biochemical Journal, s. 441-452, 2014.

  • Blikstad, Cecilia; Dahlström, Käthe; Salminen, Tiina; Widersten, Mikael et al.

    Substrate scope and selectivity in offspring to an enzyme subjected to directed evolution

    Ingår i The FEBS Journal, s. 2387-2398, 2014.

  • Haugaard-Kedstrom, L. M.; Albertsen, L.; Gil, F. Abalde; Ivarsson, Ylva et al.

    The Development and Characterization of a Peptide-Based Syntenin Inhibitor: Implacations for Cancer Metastasis

    Ingår i Journal of Peptide Science, s. S39-S39, 2014.

  • Manfroni, Giuseppe; Cannalire, Rolando; Barreca, Maria Letizia; Kaushik-Basu, Neerja et al.

    The Versatile Nature of the 6-Aminoquinolone Scaffold: Identification of Submicromolar Hepatitis C Virus NS5B Inhibitors

    Ingår i Journal of Medicinal Chemistry, s. 1952-1963, 2014.

  • Lampa, Anna; Alogheli, Hiba; Ehrenberg, Angelica E.; Åkerblom, Eva et al.

    Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

    Ingår i Bioorganic & Medicinal Chemistry, s. 6595-6615, 2014.

  • Zhang, Wei; Mannervik, Bengt

    An improved dual-tube megaprimer approach for multi-site saturation mutagenesis

    Ingår i World Journal of Microbiology & Biotechnology, s. 667-672, 2013.

  • Ragnarsson, Ulf; Grehn, Leif

    Dual protection of amino functions involving Boc

    Ingår i RSC Advances, s. 18691-18697, 2013.

  • Christopeit, Tony; Øverbø, Kersti; Danielson, Helena; Nilsen, Inge W. et al.

    Efficient Screening of Marine Extracts for Protease Inhibitors by Combining FRET Based Activity Assays and Surface Plasmon Resonance Spectroscopy Based Binding Assays

    Ingår i Marine Drugs, s. 4279-4293, 2013.

  • Sun, Song; Zhang, Wei; Mannervik, Bengt; Andersson, Dan I. et al.

    Evolution of Broad Spectrum beta-Lactam Resistance in an Engineered Metallo-beta-lactamase

    Ingår i Journal of Biological Chemistry, s. 2314-2324, 2013.

  • Musdal, Yaman; Hegazy, Usama M.; Aksoy, Yasemin; Mannervik, Bengt et al.

    FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1

    Ingår i Chemico-Biological Interactions, s. 53-62, 2013.

  • Shibata, Aya; Nakano, Yukiko; Ito, Mika; Araki, Mika et al.

    Fluorogenic probes using 4-substituted-2-nitrobenzenesulfonyl derivatives as caging groups for the analysis of human glutathione transferase catalyzed reactions

    Ingår i The Analyst, s. 7326-7330, 2013.

  • C2:301, BMC, Uppsala University, Husargatan 3, Uppsala 2013-11-29 kl 10:15

    Nordström, Helena

    Fragment Based Drug Discovery with Surface Plasmon Resonance Technology

  • Paredes, J. A.; Zhou, X.; Höglund, Stefan; Karlsson, A. et al.

    Gene Expression Deregulation in Postnatal Skeletal Muscle of TK2 Deficient Mice Reveals a Lower Pool of Proliferating Myogenic Progenitor Cells

    Ingår i PLoS ONE, s. e53698-, 2013.

  • Winquist, Johan; Geschwindner, Stefan; Xue, Yafeng; Gustavsson, Lars et al.

    Identification of Structural-Kinetic and Structural-Thermodynamic Relationships for Thrombin Inhibitors

    Ingår i Biochemistry, s. 613-626, 2013.

  • Poon, Jia-fei; Singh, Vijay P.; Engman, Lars

    In Search of Catalytic Antioxidants-(Alkyltelluro)phenols, (Alkyltelluro)resorcinols, and Bis(alkyltelluro)phenols

    Ingår i Journal of Organic Chemistry, s. 6008-6015, 2013.

  • Dourado, Daniel F. A. R.; Fernandes, Pedro Alexandrino; Ramos, Maria Joao; Mannervik, Bengt et al.

    Mechanism of Glutathione Transferase P1-1-Catalyzed Activation of the Prodrug Canfosfamide (TLK286, TELCYTA)

    Ingår i Biochemistry, s. 8069-8078, 2013.

  • B42, Biomedical Center (BMC), Husargatan 3, Uppsala 2013-06-05 kl 13:15

    Modén, Olof

    Mutational Analysis and Redesign of Alpha-class Glutathione Transferases for Enhanced Azathioprine Activity

  • Sal: B42, BMC, Husargatan 3, Uppsala 2013-12-13 kl 14:00

    Kjellander, Marcus

    Nanoporous Aluminum Oxide – A Promising Support for Modular Enzyme Reactors

  • Löfling, Annica

    Novel assay formats for improved immunoassay sensitivity in a minaturised CD-microlaboratory

    Ingår i Biochemistry, 2013.

  • Winquist, Johan; Abdurakhmanov, Eldar; Baraznenok, Vera; Henderson, Ian et al.

    Resolution of the Interaction Mechanisms and Characteristics of Non-nucleoside Inhibitors of Hepatitis C Virus Polymerase - Laying the Foundation for Discovery of Allosteric HCV Drugs

    Ingår i Antiviral Research, s. 356-368, 2013.

  • Kjellander, Marcus; Gotz, Kathrin; Liljeruhm, Josefine; Boman, Mats et al.

    Steady-state generation of hydrogen peroxide: kinetics and stability of alcohol oxidase immobilized on nanoporous alumina

    Ingår i Biotechnology letters, s. 585-590, 2013.

  • Blikstad, Cecilia; Dahlström, Kärthe M.; Salminen, Tiina A.; Widersten, Mikael et al.

    Stereoselective oxidation of aryl-substituted vicinal diols into chiral α-hydroxy aldehydes by re-engineered propanediol oxidoreductase

    Ingår i ACS Catalysis, s. 3016-3025, 2013.

  • Valegard, Karin; Iqbal, Aman; Kershaw, Nadia J.; Ivison, David et al.

    Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway

    Ingår i Acta Crystallographica Section D, s. 1567-1579, 2013.

  • Valegard, Karin; Iqbal, Aman; Kershaw, Nadia J.; Ivison, David et al.

    Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway

    Ingår i Acta Crystallographica Section D, s. 1567-1579, 2013.

  • Valegård, Karin; Iqbal, Aman; Kershaw, Nadia J.; Ivison, David et al.

    Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway

    Ingår i Acta Crystallographica Section D, s. 1567-1579, 2013.

  • Kesters, D.; Thompson, A. J.; Brams, M.; Van Elk, R. et al.

    Structural basis of ligand recognition in 5-HT3 receptors

    Ingår i EMBO Reports, s. 49-56, 2013.

  • Barreca, Maria Letizia; Manfroni, Giuseppe; Leyssen, Pieter; Winquist, Johan et al.

    Structure-Based Discovery of Pyrazolobenzothiazine Derivatives As Inhibitors of Hepatitis C Virus Replication

    Ingår i Journal of Medicinal Chemistry, s. 2270-2282, 2013.

  • Gossas, Thomas; Nordström, Helena; Xu, Ming-Hua; Sun, Zhi-Hua et al.

    The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors: characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors

    Ingår i MedChemComm, s. 432-442, 2013.

  • Gorny, Xenia; Mikhaylova, Marina; Seeger, Christian; Reddy, Pasham Parameshwar et al.

    AKAP79/150 interacts with the neuronal calcium-binding protein caldendrin

    Ingår i Journal of Neurochemistry, s. 714-726, 2012.

  • Gossas, Thomas; Vrang, Lotta; Henderson, Ian; Sedig, Susanne et al.

    Aliskiren displays long-lasting interactions with human renin

    Ingår i Naunyn-Schmiedeberg's Archives of Pharmacology, s. 219-224, 2012.

  • Seeger, Christian; Christopeit, Tony; Fuchs, K.; Grote, K. et al.

    Corrigendum to "Histaminergic pharmacology of homo-oligomeric β3 γ-aminobutyric acid type A receptors characterized by surface plasmon resonance biosensor technology" (Biochemical Pharmacology (2012) 84 (341-351))

    Ingår i Biochemical Pharmacology, s. 1541-, 2012.

  • Dominguez, Jose L.; Gossas, Thomas; Carmen Villaverde, M.; Danielson, U. Helena et al.

    Experimental and 'in silico' analysis of the effect of pH on HIV-1 protease inhibitor affinity: Implications for the charge state of the protein ionogenic groups

    Ingår i Bioorganic & Medicinal Chemistry, s. 4838-4847, 2012.

  • Eklund, Sandra; Lindås, Ann-Christin; Hamnevik, Emil; Widersten, Mikael et al.

    Exploring the active site of tripeptidyl-peptidase II through studies of pH dependence of reaction kinetics

    Ingår i Biochimica et Biophysica Acta - Proteins and Proteomics, s. 561-570, 2012.

  • Mannervik, Bengt

    Five Decades with Glutathione and the GSTome

    Ingår i Journal of Biological Chemistry, s. 6072-6083, 2012.

  • Seeger, Christian; Christopeit, Tony; Fuchs, Karoline; Grote, Katharina et al.

    Histaminergic pharmacology of homo-oligomeric beta 3 gamma-aminobutyric acid type A receptors characterized by surface plasmon resonance biosensor technology

    Ingår i Biochemical Pharmacology, s. 341-351, 2012.

  • Musdal, Y.; Ertan-Bolelli, T.; Bolelli, K.; Yilmaz, S. et al.

    Inhibition of human glutathione transferase P1-1 by novel benzazole derivatives

    Ingår i Türk Biyokimya Dergisi, s. 431-436, 2012.

  • Ragnarsson, Ulf; Grehn, Leif

    Insights into sulfinate formation from tosyl hydrazides

    Ingår i Tetrahedron Letters, s. 1045-1047, 2012.

  • Seeger, Christian; Gorny, Xenia; Reddy, Pasham Parameshwar; Seidenbecher, Constanze et al.

    Kinetic and mechanistic differences in the interactions between caldendrin and calmodulin with AKAP79 suggest different roles in synaptic function

    Ingår i Journal of Molecular Recognition, s. 495-503, 2012.

  • Zhang, Wei; Dourado, Daniel F. A. R.; Fernandes, Pedro; Ramos, Maria et al.

    Multidimensional epistasis and fitness landscapes in enzyme evolution

    Ingår i Biochemical Journal, s. 39-46, 2012.

  • Modén, Olof; Zhang, Wei; Mannervik, Bengt

    Mutational analysis of human glutathione transferase A2-2 identifies structural elements supporting high activity with the prodrug azathioprine

    Ingår i Protein Engineering Design & Selection, s. 189-197, 2012.

  • Janfalk Carlsson, Åsa; Bauer, Paul; Ma, Huan; Widersten, Mikael et al.

    Obtaining optical purity for product diols in enzyme-catalyzed epoxide hydrolysis: contributions from changes in both enantio- and regioselectivity

    Ingår i Biochemistry, s. 7627-7637, 2012.

  • B41, BMC, Uppsala University, Husargatan 3, Uppsala 2012-05-30 kl 13:15

    Winquist, Johan

    Reducing Attrition via Improved Strategies for Pre-clinical Drug Discovery: SPR-biosensor Aided Interaction Studies

  • Ito, Mika; Shibata, Aya; Zhang, Jie; Hiroshima, Michio et al.

    Universal Caging Group for the in-Cell Detection of Glutathione Transferase Applied to 19F NMR and Bioluminogenic Probes

    Ingår i ChemBioChem (Print), s. 1428-1432, 2012.

  • Christopeit, Tony; Stenberg, Gun; Gossas, Thomas; Nyström, Susanne et al.

    A surface plasmon resonance-based biosensor with full-length BACE1 in a reconstituted membrane

    Ingår i Analytical Biochemistry, s. 14-22, 2011.

  • Brunnström, Åsa; Hamberg, Mats; Griffiths, William J.; Mannervik, Bengt et al.

    Biosynthesis of 14,15-Hepoxilins in Human L1236 Hodgkin Lymphoma Cells and Eosinophils

    Ingår i Lipids, s. 69-79, 2011.

  • Fedulova, Natalia; Raffalli-Mathieu, Francoise; Mannervik, Bengt

    Characterization of porcine Alpha-class glutathione transferase A1-1

    Ingår i Archives of Biochemistry and Biophysics, s. 205-211, 2011.

  • Brandt, Peter; Geitmann, Matthis; Danielson, U Helena

    Deconstruction of Non-Nucleoside Reverse Transcriptase Inhibitors of Human Immunodeficiency Virus Type 1 for Exploration of the Optimization Landscape of Fragments

    Ingår i Journal of Medicinal Chemistry, 2011.

  • C2:301, BMC, Husargatan 3, Uppsala 2011-10-21 kl 10:15

    Zhang, Wei

    Directed Evolution of Glutathione Transferases with Altered Substrate Selectivity Profiles: A Laboratory Evolution Study Shedding Light on the Multidimensional Nature of Epistasis

  • Fedulova, Natalia; Mannervik, Bengt

    Experimental Conditions Affecting Functional Comparison of Highly Active Glutathione Transferases

    Ingår i Analytical Biochemistry, s. 16-23, 2011.

  • Elinder, Malin; Geitmann, Matthis; Gossas, Thomas; Källblad, Per et al.

    Experimental Validation of a Fragment Library for Lead Discovery Using SPR Biosensor Technology

    Ingår i Journal of Biomolecular Screening, s. 15-25, 2011.

  • Lopes Pinto, Fernando; Erasmie, Sven; Blikstad, Cecilia; Lindblad, Peter et al.

    FtsZ degradation in the cyanobacterium Anabaena sp. strain PCC 7120

    Ingår i Journal of plant physiology (Print), s. 1934-1942, 2011.

  • Geitmann, Matthis; Elinder, Malin; Seeger, Christian; Brandt, Peter et al.

    Identification of a Novel Scaffold for Allosteric Inhibition of Wild Type and Drug Resistant HIV-1 Reverse Transcriptase by Fragment Library Screening

    Ingår i Journal of Medicinal Chemistry, s. 699-708, 2011.

  • B7:101a, BMC, Husargatan 3, Uppsala 2011-01-21 kl 09:15

    Eklund, Sandra

    Interpreting a Giant: Studies of Structure and Function of Tripeptidyl-peptidase II

  • Geitmann, Matthis; Dahl, Göran; Danielson, U. Helena

    Mechanistic and kinetic characterization of hepatitis C virus NS3 protein interactions with NS4A and protease inhibitors

    Ingår i Journal of Molecular Recognition, s. 60-70, 2011.

  • Cassimjee, Karim Engelmark; Kourist, Robert; Lindberg, Diana; Wittrup Larsen, Marianne et al.

    One-step enzyme extraction and immobilization for biocatalysis applications

    Ingår i Biotechnology Journal, s. 463-469, 2011.

  • Tegler, Lotta T.; Nonglaton, Guillaume; Büttner, Frank; Caldwell, Karin et al.

    Powerful protein binders from designed polypeptides and small organic molecules: a general concept for protein recognition

    Ingår i Angewandte Chemie International Edition, s. 1823-1827, 2011.

  • Gustafsson, Sofia S.; Vrang, Lotta; Terelius, Ylva; Danielson, Helena et al.

    Quantification of interactions between drug leads and serum proteins by use of "binding efficiency"

    Ingår i Analytical Biochemistry, s. 163-175, 2011.

  • Larsson, Emilia; Mannervik, Bengt; Raffalli-Mathieu, Francoise

    Quantitative and selective polymerase chain reaction analysis of highly similar human alpha-class glutathione transferases

    Ingår i Analytical Biochemistry, s. 96-101, 2011.

  • Lindberg, Diana; de la Fuente Revenga, Mario; Widersten, Mikael

    Deep eutectic solvents (DESs) are viable cosolvents for enzyme-catalyzed epoxide hydrolysis

    Ingår i Journal of Biotechnology, s. 169-171, 2010.

  • Retra, Kim; Geitmann, Matthis; Kool, Jeroen; Smit, August B et al.

    Development of surface plasmon resonance biosensor assays for primary and secondary screening of acetylcholine binding protein ligands

    Ingår i Analytical Biochemistry, s. 58-64, 2010.

  • Örtqvist, Pernilla; Gising, Johan; Ehrenberg, Angelica; Vema, Aparna et al.

    Discovery of Achiral Inhibitors of the Hepatitis C Virus NS3 Protease based on 2(1H)-pyrazinones

    Ingår i Bioorganic & Medicinal Chemistry, s. 6512-6525, 2010.

  • Lampa, Anna; Ehrenberg, Angelica E.; Gustafsson, Sofia S.; Vema, Aparna et al.

    Improved P2 phenylglycine-based hepatitis C virus NS3 protease inhibitors with alkenylic prime-side substituents

    Ingår i Bioorganic & Medicinal Chemistry, s. 5413-5424, 2010.

  • Geitmann, Matthis; Retra, Kim; de Kloe, Gerdien E; Homan, Evert et al.

    Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein

    Ingår i Biochemistry, s. 8143-8154, 2010.

  • Ghasemzadeh, Nasim; Tore W. Wilhelmsen, Tore W.; Nyberg, Fred; Hjertén, Stellan et al.

    Precautions to improve the accuracy of quantitative determinations of biomarkers in clinical diagnostics

    Ingår i Electrophoresis, s. 2722-2729, 2010.

  • Örtqvist, Pernilla; Vema, Aparna; Ehrenberg, Angelica E; Dahl, Göran et al.

    Structure-activity relationships of HCV NS3 protease inhibitors evaluated on the drug-resistant variants A156T and D168V

    Ingår i Antiviral Therapy, s. 841-852, 2010.

  • de Kloe, Gerdien E; Retra, Kim; Geitmann, Matthis; Källblad, Per et al.

    Surface Plasmon Resonance Biosensor Based Fragment Screening Using Acetylcholine Binding Protein Identifies Ligand Efficiency Hot Spots (LE Hot Spots) by Deconstruction of Nicotinic Acetylcholine Receptor α7 Ligands

    Ingår i Journal of Medicinal Chemistry, s. 7192-7201, 2010.

  • Lindberg, Diana; de la Fuente Revenga, Mario; Widersten, Mikael

    Temperature and pH dependence of enzyme catalyzed hydrolysis of trans-methylstyrene oxide: a unifying kinetic model for observed hysteresis, cooperativity and regioselectivity

    Ingår i Biochemistry, s. 2297-2304, 2010.

  • Mannervik, Bengt; Rúnarsdóttir, Arna

    The quest for molecular quasi-species in ligand-activity space and its application to directed enzyme evolution

    Ingår i FEBS Letters, s. 2565-2571, 2010.

  • Danielson, U Helena

    Fragment library screening and lead characterization using SPR biosensors

    Ingår i Current Topics in Medicinal Chemistry, s. 1725-1735, 2009.

  • Patrick, Ferdinandi; Mtui, Godliving; Mshandete, Anthony; Johansson, Gunnar et al.

    Purification and characterization of a laccase from the basidiomycete Funalia trogii (Berk.) isolated in Tanzania

    Ingår i African Journal of Biochemistry Research, s. 250-259, 2009.

  • Filonova, Lada; Kallas, Åsa; Greffe, Lionel; Johansson, Gunnar et al.

    Analysis of the Surfaces of Wood Tissues and Pulp Fibers Using Carbohydrate-Binding Modules Specific for Crystalline Cellulose and Mannan

    Ingår i Biomacromolecules, s. 91-97, 2007.

  • Raffalli-Mathieu, Francoise; Persson, David; Mannervik, Bengt

    Differences between bovine and human steroid double-bond isomerase activities of Alpha-class glutathione transferases selectively expressed in steroidogenic tissues

    Ingår i Biochimica et Biophysica Acta - General Subjects, s. 130-136, 2007.

  • Söderberg, Malin; Raffalli-Mathieu, Françoise; Lang, Matti A.

    Identification of a regulatory cis-element within the 3 '-untranslated region of the murine inducible nitric oxide synthase (NOS) mRNA: interaction with heterogeneous nuclear ribonucleoproteins I and L and role in the NOS gene expression

    Ingår i Molecular Immunology, s. 434-442, 2007.

  • Nurbo, Johanna; Dahl, G; Danielson, U Helena; Sandström, Anja et al.

    Investigation of beta-amino acids as building blocks in hepatitis c virus NS3 protease inhibitors

    Ingår i Molecular Immunology, 2007.

  • Abdurahman, Samir; Höglund, Stefan; Höglund, Anders; Vahlne, Anders et al.

    Mutation in the loop C-terminal to the cyclophilin A binding site of HIV-1 capsid protein disrupts proper virus assembly and infectivity

    Ingår i Retrovirology, s. 19-, 2007.

  • Ivarsson, Ylva; Norrgård, Malena A; Tars, Kaspar; Mannervik, Bengt et al.

    A positively selected residue influences enzyme functionalities

    Ingår i The FASEB Journal, s. A474-, 2006.

  • Park, Hee-Sung; Nam, Sung-Hun; Lee, Jin Kak; Yoon, Chang No et al.

    Design and evolution of new catalytic activity with an existing protein scaffold.

    Ingår i Science, s. 535-8, 2006.

  • Kurtovic, Sanela; Emrén, Lars O; Runarsdottír, Arna; Larsson, Anna-Karin et al.

    Identification of functionally diverging quasi-species in molecular enzyme evolution

    Ingår i The FASEB Journal, s. A470-, 2006.

  • Simonsson, Ulrika S.H.; Lindell, Monica; Raffalli-Mathieu, Francoise; Lannerbro, Angela et al.

    In vivo and mechanistic evidence of nuclear receptor CAR induction by artemisinin

    Ingår i European Journal of Clinical Investigation, s. 647-653, 2006.

  • Sookkongwaree, K; Geitmann, Matthis; Roengsumran, S; Petsom, A et al.

    Inhibition of viral proteases by Zingiberaceae extracts and flavones isolated from Kaempferia parviflora

    Ingår i Pharmazie, s. 717-721, 2006.

  • Liljestrand, Johan

    Interaction, Organisation, Tasks and Possibilities for Learning about Mathematical Relationships:: A Swedish Classroom Compared with a US Classroom

    Ingår i Pharmazie, 2006.

  • Ellfolk, Maria; Norlin, Maria; Wikvall, Kjell

    Isolation and properties of the CYP2D25 promoter: Transcriptional regulation by vitamin D3 metabolites

    Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 568-572, 2006.

  • Barman, Jharna; Acharya, Sandipta; Zhou, Chuanzheng; Chatterjee, Subhrangsu et al.

    Non-identical electronic characters of the internucleotidic phosphates in RNA modulate the chemical reactivity of the phosphodiester bonds.

    Ingår i Org Biomol Chem, s. 928-41, 2006.

  • Josephy, P. David; Taylor, Patricia L.; Vervaet, Gaby; Mannervik, Bengt et al.

    Screening and characterization of variant Theta-class glutathione transferases catalyzing the activation of ethylene dibromide to a mutagen

    Ingår i Environmental and Molecular Mutagenesis, s. 657-665, 2006.

  • Gutierrez Arenas, Omar; Danielson, U Helena

    Sensitivity analysis and error structure of progress curves

    Ingår i Analytical Biochemistry, s. 1-10, 2006.

  • Takatsy, Aniko; Kilár, Aniko; Kilár, Ferenc; Hjertén, Stellan et al.

    Universal method for synthesis of artificial gel antibodies by the imprinting approach combined with a unique electrophoresis technique for detection of minute structural differences of proteins, viruses and cells (bacteria): Ia. Gel antibodies against proteins (transferrins)

    Ingår i Journal of Separation Science, s. 2802-2809, 2006.

  • Takatsy, Aniko; Sedzik, Jan; Kilar, Ferenc; Hjertén, Stellan et al.

    Universal method for synthesis of artificial gel antibodies by the imprinting approach combined with a unique electrophoresis technique for detection of minute structural differences of proteins, viruses, and cells (bacteria): II. Gel antibodies against virus (Semliki Forest Virus)

    Ingår i Journal of Separation Science, s. 2810-2815, 2006.

  • Bacskay, Ivett; Takatsy, Aniko; Vegvari, Akos; Elfwing, Anders et al.

    Universal method for synthesis of artificial gel antibodies by the imprinting approach combined with a unique electrophoresis technique for detection of minute structural differences of proteins, viruses, and cells (bacteria). III: Gel antibodies against cells (bacteria)

    Ingår i Electrophoresis, s. 4682-4687, 2006.

  • Eklund, Birgitta; Elfarra, Adnan A.; Mannervik, Bengt

    Activation of anticancer prodrugs by human glutathione transferases

    Ingår i FEBS Journal, s. 546 Suppl-, 2005.

  • Elfström, Lisa; Widersten, Mikael

    Catalysis of potato epoxide hydrolase, StEH1

    Ingår i Biochemical Journal, s. 633-640, 2005.

  • Akoachere, Monique; Iozef, Rimma; Rahlfs, Stefan; Deponte, Marcel et al.

    Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts.

    Ingår i Biol Chem, s. 41-52, 2005.

  • Johansson, Emma; Engvall, Caroline; Arfvidsson, Maria; Lundahl, Per et al.

    Development and initial evaluation of PEG-stabilized disks as novel model membranes

    Ingår i Biophysical Chemistry, s. 183-192, 2005.

  • Kurtovic, Sanela; Runarsdottir, Arna; Larsson, Anna-Karin; Emrén, Lars O et al.

    Diverging substrate specificites from a glutathione transferase library analyzed by multivariate methods

    Ingår i FEBS Journal, s. 90 Suppl-, 2005.

  • Andersson, Malena; Mannervik, Bengt

    Exploring protein evolution by saturation mutagenesis of the GST M2-2 active site residue 210

    Ingår i FEBS Journal, s. 81 Suppl-, 2005.

  • Ivarsson, Ylva; Mannervik, Bengt

    Exploring the importance of an active site residue on the stereo and regio selectivity of Mu class glutathione transferases

    Ingår i FEBS Journal, s. 88 Suppl-, 2005.

  • Raffalli-Mathieu, Francoise; Mannervik, Bengt

    Human glutathione transferase A3-3 active as steroid double-bond isomerase

    Ingår i Methods of Enzymology, s. 265-278, 2005.

  • Lindås, Ann-Christin; Tomkinson, Birgitta

    Identification and characterization of the promoter for the gene encoding human tripeptidyl-peptidase II.

    Ingår i Gene, s. 249-57, 2005.

  • Jonas, Kristina; Van Der Vries, Erhard; Nilsson, Mikael T.I.; Widersten, Mikael et al.

    Isolation of novel single-chain Cro proteins targeted for binding to the bcl-2 transcription initiation site by repertoire selection and subunit combinatorics

    Ingår i Protein Engineering Design & Selection, s. 537-546, 2005.

  • Stavropoulou, Vaia; Xie, Jianjun; Henriksson, Marie; Tomkinson, Birgitta et al.

    Mitotic infidelity and centrosome duplication errors in cells overexpressing tripeptidyl-peptidase II.

    Ingår i Cancer Res, s. 1361-8, 2005.

  • Mannervik, Bengt; Board, Philip G; Hayes, John D; Listowsky, Irving et al.

    Nomenclature for mammalian soluble glutathione transferases

    Ingår i Methods of Enzymology, s. 1-8, 2005.

  • Rönn, Robert; Gossas, T; Sabnis, Y A; Åkerblom, E et al.

    Novel C-terminal functionalities in hepatitis C virus NS3 protease inhibitors

    Ingår i Methods of Enzymology, 2005.

  • Mannervik, Bengt

    Optimizing the heterologous expression of glutathione transferase

    Ingår i Methods of Enzymology, s. 254-265, 2005.

  • Edalat, Maryam H; Mannervik, Bengt

    Peptide phage display for probing GST-protein interactions.

    Ingår i Methods Enzymol, s. 354-67, 2005.

  • Kipper, Kalle; Väljamäe, Priit; Johansson, Gunnar

    Processive action of cellobiohydrolase Cel7A from Trichoderma reesei is revealed as a

    Ingår i Biochemical Journal, s. 1-9, 2005.

  • Ivarsson, Ylva; Mannervik, Bengt

    Regio- and enantioselectivities in epoxide conjugations are modulated by residue 210 in Mu class glutathione transferases.

    Ingår i Protein Eng Des Sel, s. 607-16, 2005.

  • Shokeer, Abeer; Larsson, Anna-Karin; Mannervik, Bengt

    Residue 234 in glutathione transferase T1-1 plays a pivotal role in the catalytic activity and the selectivity against alternative substrates

    Ingår i Abstracts of the 30th FEBS Congress, s. 99 Suppl-, 2005.

  • Shokeer, Abeer; Larsson, Anna-Karin; Mannervik, Bengt

    Residue 234 in glutathione transferase T1-1 plays a pivotal role in the catalytic activity and the selectivity against alternative substrates

    Ingår i Biochemical Journal, s. 387-92, 2005.

  • Hegazy, Usama; Mannervik, Bengt

    Site-directed substitution of the key residue at the subunit interface of GST P1-1 by S-alkylcysteine residues sustains glutathione binding and catalytic activity of the enzyme

    Ingår i FEBS Journal, s. 87 Suppl-, 2005.

  • Elfström, Lisa; Widersten, Mikael

    The Saccharomyces cerevisiae ORF YNR064c protein has characteristics of an 'orphaned' epoxide hydrolase

    Ingår i Biochimica et Biophysica Acta - Proteins and Proteomics, s. 213-221, 2005.

  • Tomkinson, Birgitta; Lindås, Ann-Christin

    Tripeptidyl-peptidase II: a multi-purpose peptidase.

    Ingår i Int J Biochem Cell Biol, s. 1933-7, 2005.

  • Hederos, Sofia; Broo, Kerstin; Jakobsson, Emma; Kleywegt, Gerard J et al.

    A new enzyme by rational design - the incorporation of a single His residue enables efficient thioester hydrolysis by human glutathione transferase A1-1

    Ingår i Proc. Nat. Acad. Sci., s. 13163-13167, 2004.

  • Nilsson, Mikael; Johansson, Gunnar; Isaksson, Roland

    Determination of affinity constants by competitive binding in partial filling capillary electrophoresis

    Ingår i Electrophoresis, s. 1022-1027, 2004.

  • Shuman, Cynthia; Vrang, Lotta; Danielson, U. Helena

    Improved structure-activity relationship analysis of HIV-1 protease inhibitors using interaction kinetic data

    Ingår i Journal of Medicinal Chemistry, s. 5953-61, 2004.

  • Hederos, Sofia; Broo, Kerstin S; Jakobsson, Emma; Kleywegt, Gerard J et al.

    Incorporation of a single His residue by rational design enables thiol-ester hydrolysis by human glutathione transferase A1-1.

    Ingår i Proc Natl Acad Sci U S A, s. 13163-7, 2004.

  • Wisén, Susanne; Bergman, Birgitta; Mannervik, Bengt

    Mutagenesis of the cysteine residues in the transcription factor NtcA from Anabaena PCC 7120 and its effects on DNA binding in vitro.

    Ingår i Biochim Biophys Acta, s. 156-63, 2004.

  • Poliakov, Anton; Johansson, A; Åkerblom, E; Lindeberg, G et al.

    Optimisation of peptide-based inhibitors of full-length hepatitis C virus NS3 protease

    Ingår i Biochim Biophys Acta, 2004.

  • Nilsson, Mikael T.I.; Widersten, Mikael

    Repertoire selection of variant single-chain Cro: towards directed DNA-binding specificity of helix-turn-helix proteins

    Ingår i Biochemistry, s. 12038-12047, 2004.

  • Edalat, Maryam; Mannervik, Bengt; Axelsson, Lars-Göran

    Selective expression of detoxifying glutathione transferases in mouse colon: effect of experimental colitis and the presence of bacteria.

    Ingår i Histochem Cell Biol, s. 151-9, 2004.

  • Tomkinson, Birgitta

    Tripeptidyl-peptidase II

    Ingår i Handbook of proteolytic enzymes, s. 1882-1885, 2004.

  • Beyer, B; Rubin, J; Johnson, J; Chung, A et al.

    Candida albicans secreted aspartic peptidase specificity: A chromogenic combinatorial approach

    Ingår i Biopolymers, s. 310-P025, 2003.

  • Raices, Manuel; Montesino, Raquel; Cremata, Jose; Szabó, István et al.

    Cellobiose Quinone Oxidoreductase from the white rot fungus Phanerochaete chrysosporium is produced by intracellular proteolysis of Cellobiose Dehydrogenase.

    Ingår i Biochimica et Biophysica Acta: Gene Structure and expression, s. 15-22, 2002.

  • Bodin, Karl; Andersson, Ulla; Rystedt, Eva; Ellis, Eva et al.

    Metabolism of 4 beta -hydroxycholesterol in humans

    Ingår i Journal of Biological Chemistry, s. 31534-31540, 2002.

  • Henriksson, Hongbin; Pettersson, Göran; Johansson, Gunnar

    Discrimination between enantioselective and non-selective binding sites on cellobiohydrolase-based stationary phases by selective displacers

    Ingår i Journal of Chromatography A, s. 107-115, 1999.

  • Danielson, U. Helena; Jiang, Fanyi Y; Hansson, Lars O.; Mannervik, Bengt et al.

    Probing the kinetic mechanism and coenzyme specificity of glutathione reductase from the cyanobacterium Anabaena PCC 7120 by redesign of the pyridine-nucleotide-binding site

    Ingår i Biochemistry, s. 9254-9263, 1999.

  • Tomkinson, Birgitta

    Tripeptidyl peptidases: enzymes that count.

    Ingår i Trends Biochem Sci, s. 355-9, 1999.

  • Karlsson, E; Harvey, A L; Cervenansky, C; Kleywegt, G J et al.

    Fasciculins, cholinesterase inhibitors from mamba venoms

    Ingår i Enzymes from snake venom, s. 633-688, 1998.

  • Väljamäe, Priit; Sild, Veljo; Pettersson, Göran; Johansson, Gunnar et al.

    The Initial Kinetics of Hydrolysis by Cellobiohydrolases I and II is Consistent with a Cellulose Surface-Erosion Model

    Ingår i European Journal of Biochemistry, s. 469-475, 1998.

  • Kolm, Rüdiger H.; Danielson, U Helena; Zhang, Y.uesheng; Talalay, Paul et al.

    Isothiocyanates as substrates for human glutathione transferases: structure-activity studies

    Ingår i Biochemical Journal, s. 453-459, 1995.

  • Loog, Mart; Eller, Marika; Ekman, Pia; Engström, Lorentz et al.

    Comparision of substrate specificities of protein kinases A and C based on peptide substrates

    Ingår i Bioorganic chemistry (Print), s. 328-336, 1994.

  • Toomik, Reet; Eller, Marika; Ekman, Pia; Ragnarsson, Ulf et al.

    D-amino acid residues as substrate specificity determinants for casein kinase II

    Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 1564-1569, 1994.

  • Chaga, Grigoriy; Widersten, Mikael; Andersson, Lennart; Porath, Jerker et al.

    Engineering of a metal coordinating site into human glutathione transferase M1-1 based on immobilized metal ion affinity chromatography of homologous rat enzymes

    Ingår i Protein Engineering, s. 1115-1119, 1994.

  • Toomik, Reet; Ekman, Pia; Eller, Marika; Järv, Jaak et al.

    Protein kinase assay using tritiated peptide substrates and ferric adsorbent paper for phosphopeptide binding

    Ingår i Analytical Biochemistry, s. 348-353, 1993.

  • Eller, Marika; Järv, Jaak; Toomik, Reet; Ragnarsson, Ulf et al.

    Substrate specificity of protein kinase C studied with peptides containing D-amino acid residues.

    Ingår i Journal of Biochemistry, s. 177-180, 1993.

  • Sinning, I; Kleywegt, G J; Mannervik, B; Board, P G et al.

    The active site in class alpha glutathione transferases

    Ingår i Structure and Function of Glutathione Transferases, s. 75-85, 1993.

  • Muszynska, Grazyna; Dobrowolska, Grazyna; Medin, Anders; Ekman, Pia et al.

    Model studies on iron (III) ion affinity chromatography: II. Interaction of immobilized ferric ions with phosphorylated amino acids, peptides and proteins

    Ingår i Journal of Chromatography A, s. 19-28, 1992.

  • Eller, Marika; Järv, Jaak; Toomik, Reet; Ragnarsson, Ulf et al.

    Peptide fragments of myelin basic protein as substrates of protein kinase C.

    Ingår i Biochemistry International, s. 625-631, 1992.

  • Ekman, Pia; Eller, Marika; Ragnarsson, Ulf; Engström, Lorentz et al.

    Two methods to avoid the effect of endogenous inhibitors during the assay of protein kinase C activity in tissue extracts.

    Ingår i Preparative Biochemistry, s. 165-175, 1992.

  • Eller, Marika; Sepp, A; Toomik, Reet; Ekman, Pia et al.

    Studies on the substrate specificity of cAMP-dependent protein kinase using diastereomeric peptides

    Ingår i Biochemistry International, s. 453-460, 1991.

  • Neuzil, Jiri; Danielson, Helena; Welch, G Rickey; Ovádi, Judit et al.

    Cooperative effect of fructose bisphosphate and glyceraldehyde-3-phosphate dehydrogenase on aldolase action

    Ingår i Biochimica et Biophysica Acta, s. 307-312, 1990.

  • Wallin, Margareta; Deinum, Johanna; Goobar, Laura; Danielson, U Helena et al.

    Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases

    Ingår i Journal of General Virology, s. 1985-1991, 1990.

  • Gogoll, Adolf; Oscarsson, Sven

    Reaction of pyridine derivatives with butyl glycidyl ether as a model system for glycidyl ether modified agarose: structural assignment by selective inept spectra

    Ingår i Tetrahedron, s. 2539-2548, 1990.

  • Mannervik, Bengt; Danielson, U Helena

    Glutathione transferases - structure and catalytic activity

    Ingår i Crc Critical Reviews in Biochemistry, s. 283-337, 1988.

  • Danielson, U Helena; Mannervik, Bengt

    Paradoxical inhibition of rat glutathione transferase 4-4 by indomethacin explained by substrate-inhibitor-enzyme complexes in a random-order sequential mechanism

    Ingår i Biochemical Journal, s. 705-711, 1988.

  • Principato, Giovanni B; Danielson, U Helena; Mannervik, Bengt

    Relaxed thiol substrate specificity of glutathione transferase effected by a non-substrate glutathione derivative

    Ingår i FEBS Letters, s. 155-158, 1988.

  • Mannervik, Bengt; Castro, Victor M; Danielson, U Helena; Platz, A et al.

    Expression of class-pi glutathione transferase in drug-resistant human-melanoma cells

    Ingår i Proceedings of the American Association of Cancer Research, s. 5-5, 1987.

  • Danielson, U Helena; Esterbauer, Hermann; Mannervik, Bengt

    Structure-activity relationships of 4-hydroxyalkenals in the conjugation catalysed by mammalian glutathione transferases

    Ingår i Biochemical Journal, s. 707-713, 1987.

  • Danielson, U Helena; Mannervik, Bengt

    Kinetic independence of the subunits of cytosolic glutathione transferase from the rat

    Ingår i Biochemical Journal, s. 263-267, 1985.

  • Ålin, Per; Jensson, Helgi; Guthenberg, Claes; Danielson, U Helena et al.

    Purification of major basic glutathione transferase isoenzymes from rat liver by use of affinity chromatography and fast protein liquid chromatofocusing

    Ingår i Analytical Biochemistry, s. 313-320, 1985.

  • Mannervik, Bengt; Ålin, P; Danielson, U Helena; Guthenberg, C et al.

    STRUCTURAL DATA AND ENZYMATIC-PROPERTIES DEFINING 3 CLASSES OF MAMMALIAN CYTOSOLIC GLUTATHIONE TRANSFERASE

    Ingår i Federation proceedings, s. 471-471, 1985.

  • Humble, Elisabet; Dahlqvist-Edberg, Ulla; Ekman, Pia; Netzel, Elvy et al.

    Amino acid sequence at the phosphorylated site of rat liver fructose-1,6-diphosphatase and phosphorylation of a corresponding synthetic peptide

    Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 1064-1072, 1979.

  • Janfalk Carlsson, Åsa; Bauer, Paul; Dobtritzsch, Doreen; Kamerlin, Shina Caroline Lynn et al.

    Epoxide Hydrolysis as a Model System for Understanding Flux Through a Branched Reaction Scheme

    Ingår i Biochemical and Biophysical Research Communications - BBRC

  • Winquist, Johan; Nordström, Helena; Geitmann, Matthis; Gossas, Thomas et al.

    New Scaffolds for Design of Inhibitors of Drug Resistant HIV-1 Protease Identified by Fragment Library Screening

    Ingår i Biochemical and Biophysical Research Communications - BBRC

  • Maurer, Dirk; Enugala, Thilak Reddy; Hamnevik, Emil; Bauer, Paul et al.

    Stereoselectivity in Catalyzed Transformation of a 1,2-Disubstituted Vicinal Diol and the Corresponding Diketone by Wild Type and Laboratory Evolved Alcohol Dehydrogenases

    Ingår i Biochemical and Biophysical Research Communications - BBRC