Samec Group

Research areas:

Joseph is running a column.

• Transfer hydrogenolysis of alcohols
• Catalytic stereospecific nucleophilic substitution of alcohols
• Allylation of amines.

Transition metal catalyzed transformation using renewable carbon sources.

While petroleum based carbon sources consists of hydrocarbons biomass consists of alcohols. In order to use biomass in synthesis we need to develop more efficient methodologies to substitute the hydroxyl group in alcohols by different nucleophiles.

While the traditional methodologies make use of stoichiometric reagents we plan to develop catalytic methodologies. All projects that we are researching in are based on the mechanistic understanding of C–O bond activation of alcohols. By studying the reaction pathway in detail, we want to develop a catalytic nucleophilic substitution of alcohols.

The practical work involves: Isolate intermediates and characterize them by NMR and X-ray; Study the kinetics and deuterium kinetic isotope effects; Optimize the reaction parameters and evaluate the substrate scoop.



Citation report for “catalytic nucleophilic substitution alcohols”

Source: Web of Science

Joseph Samec

Research fellow

Department of Chemistry

BMC - Synthetic Organic Chemistry



Office Phone: 018-471 3817

Mobile: 070-559 2511